Heterotropic regulation and negative homotropic cooperativity. [PDF]
FEBS Open BioHeterotropic regulation of protein function is crucial for such diverse cellular events as transcription, signal transduction, enzymatic activity, transport and many others.
Morea V +5 more
europepmc +3 more sources
High Cooperativity Using a Confocal-Cavity–QED Microscope [PDF]
PRX Quantum, 2023 Cavity quantum electrodynamics (QED) with cooperativity far greater than unity enables high-fidelity quantum sensing and information processing. The high-cooperativity regime is often reached through the use of short single-mode resonators.
Ronen M. Kroeze +4 more
doaj +2 more sources
Structural dynamics of the π-stacking network governing cofactor-substrate cooperativity of SbSOMT methyltransferase [PDF]
Communications ChemistrySAM-dependent methyltransferases are enzymes that catalyze the transfer of a methyl group from a cofactor to a substrate through an ordered or random sequential bi-bi mechanism. However, the structural dynamics governing binding cooperativity between the
Kah Chee Pow +6 more
doaj +2 more sources
Apparent cooperativity between human CMV virions introduces errors in conventional methods of calculating multiplicity of infection [PDF]
eLifeWhether infection of cells by individual virions occurs randomly, or if there is some form(s) of competition or cooperativity between individual virions, remains largely unknown for most virus–cell associations. Here, we studied cooperativity/competition
Christopher Peterson +3 more
doaj +2 more sources
Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay [PDF]
, 2021 Cooperativity is an important parameter to understand the ternary complexes formed by protein degraders. We developed fluorine NMR competition binding experiments to determine cooperativity of PROTACs.
Alessio, Ciulli, Guilherme, Castro
core +2 more sources
Cooperation challenges in agricultural cooperatives [PDF]
Revista de Administração da UFSM, 2021 Objective – This paper aimed to understand the elements in cooperative arrangements of agribusiness that facilitate and hinder cooperation.Design/methodology/approach -A descriptive research was carried out based on the 50 questionnaires applied to farmers´ members of cooperatives in Rio Grande do Sul, Brazil.Results - Results indicated that farmers ...
Amanda Regina Leite +2 more
openaire +2 more sources
Unexpected single ligand occupancy and negative cooperativity in the SARS-CoV-2 Main protease [PDF]
, 2023 Many homodimeric enzymes tune their function by exploiting either negative or positive cooperativity between subunits. In the SARS-CoV-2 Main protease (Mpro) homodimer, the latter has been suggested by symmetry in most of the 500 reported protease/ligand
Jörg Bernhard, Schulz +14 more
core +2 more sources
Cooperativity and Frustration Effects (or Lack Thereof) in Polarizable and Non-Polarizable Force Fields [PDF]
, 2023 Understanding cooperativity and frustration is crucial for studying biological processes, such as molecular recognition and protein aggregation. Force fields have been extensively utilized to explore cooperativity in the formation of protein secondary ...
Jean-Philip, Piquemal +3 more
core +2 more sources
Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay [PDF]
, 2021 Cooperativity is an important parameter to understand the ternary complexes formed by protein degraders. We developed fluorine NMR competition binding experiments to determine cooperativity of PROTACs.
Ciulli, Alessio +3 more
core +1 more source
Combining Metal-Metal Cooperativity, Metal-Ligand Cooperativity and Chemical Non-Innocence in Diiron Carbonyl Complexes [PDF]
, 2021 Several metalloenzymes, including [FeFe]-hydrogenase, employ cofactors wherein multiple metal atoms work together with surrounding ligands that mediate heterolytic and concerted proton-electron transfer (CPET) bond activation steps.
Daniël Laurens Johannes, Broere +5 more
core +2 more sources