Results 11 to 20 of about 41,414 (267)
Why all MODY variants in transcription factor genes are dominantly inherited [PDF]
Frontiers in GeneticsMaturity-onset diabetes of the young (MODY) is an autosomal dominant form of monogenic diabetes, frequently caused by heterozygous loss-of-function variants in transcription factor (TF) genes. Why are MODY variants in TF genes dominantly inherited?
Roman Zug, Roman Zug
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Cooperation of RNA-Binding Proteins – a Focus on Roquin Function in T Cells
Frontiers in Immunology, 2022 Post-transcriptional gene regulation by RNA-binding proteins (RBPs) is important in the prevention of inflammatory and autoimmune diseases. With respect to T cell activation and differentiation, the RBPs Roquin-1/2 and Regnase-1 play pivotal roles by ...
Gesine Behrens +2 more
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Organic Materials, 2020 We describe the synthesis of two propeller-shaped, emissive trisbiphenylamines 1 and (S)-2. Whilst achiral 1 forms supramolecular polymers following a cooperative mechanism, the self-assembly of chiral (S)-2 can be described by an isodesmic mechanism ...
Yeray Dorca +5 more
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Cooperating with machines [PDF]
Nature Communications, 2018 AbstractSince Alan Turing envisioned artificial intelligence, technical progress has often been measured by the ability to defeat humans in zero-sum encounters (e.g., Chess, Poker, or Go). Less attention has been given to scenarios in which human–machine cooperation is beneficial but non-trivial, such as scenarios in which human and machine preferences
Jacob W. Crandall +9 more
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p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo
Cell Reports, 2013 Four molecules of the tumor suppressor p53 assemble to cooperatively bind proapoptotic target genes. The structural basis for cooperativity consists of interactions between adjacent DNA binding domains.
Oleg Timofeev +8 more
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High Cooperativity Using a Confocal-Cavity–QED Microscope
PRX Quantum, 2023 Cavity quantum electrodynamics (QED) with cooperativity far greater than unity enables high-fidelity quantum sensing and information processing. The high-cooperativity regime is often reached through the use of short single-mode resonators.
Ronen M. Kroeze +4 more
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Cooperative breeders do cooperate [PDF]
Behavioural Processes, 2007 Bergmuller et al. (2007) make an important contribution to studies of cooperative breeding and provide a theoretical basis for linking the evolution of cooperative breeding with cooperative behavior. We have long been involved in empirical research on the only family of nonhuman primates to exhibit cooperative breeding, the Callitrichidae, which ...
Snowdon, C., Cronin, K.
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Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments
eLife, 2021 Regulated thin filaments (RTFs) tightly control striated muscle contraction through calcium binding to troponin, which enables tropomyosin to expose myosin-binding sites on actin. Myosin binding holds tropomyosin in an open position, exposing more myosin-
Quentin M Smith +4 more
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Molecules, 2019 A coinage-metal bond has been predicted and characterized in the complexes of [1.1.1]propellane (P) and M2/MCl/MCH3 (M = Cu, Ag, and Au). The interaction energy varies between −16 and −47 kcal/mol, indicating that the bridgehead carbon atom ...
Ruijing Wang, Shubin Yang, Qingzhong Li
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Measuring cis-regulatory energetics in living cells using allelic manifolds
eLife, 2018 Gene expression in all organisms is controlled by cooperative interactions between DNA-bound transcription factors (TFs), but quantitatively measuring TF-DNA and TF-TF interactions remains difficult.
Talitha L Forcier +5 more
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