Heterotropic regulation and negative homotropic cooperativity. [PDF]
FEBS Open BioWe identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Morea V +5 more
europepmc +2 more sources
Combining Metal-Metal Cooperativity, Metal-Ligand Cooperativity and Chemical Non-Innocence in Diiron Carbonyl Complexes [PDF]
, 2021 Several metalloenzymes, including [FeFe]-hydrogenase, employ cofactors wherein multiple metal atoms work together with surrounding ligands that mediate heterolytic and concerted proton-electron transfer (CPET) bond activation steps.
Daniël Laurens Johannes, Broere +5 more
core +2 more sources
Cooperation challenges in agricultural cooperatives [PDF]
Revista de Administração da UFSM, 2021 Objective – This paper aimed to understand the elements in cooperative arrangements of agribusiness that facilitate and hinder cooperation.Design/methodology/approach -A descriptive research was carried out based on the 50 questionnaires applied to farmers´ members of cooperatives in Rio Grande do Sul, Brazil.Results - Results indicated that farmers ...
Amanda Regina Leite +2 more
openaire +2 more sources
Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay [PDF]
, 2021 Cooperativity is an important parameter to understand the ternary complexes formed by protein degraders. We developed fluorine NMR competition binding experiments to determine cooperativity of PROTACs.
Alessio, Ciulli, Guilherme, Castro
core +2 more sources
Homotropic Cooperativity in Iron-Catalyzed Alkyne Cyclotrimerizations [PDF]
, 2023 Enhancing catalytic activity through synergic effects is a current challenge in homogeneous catalysis. In addition to the well-established metal-metal and metal-ligand cooperation, we showcase here an example of self-activation by the substrate in ...
Coles, N. T. +11 more
core +1 more source
Unexpected single ligand occupancy and negative cooperativity in the SARS-CoV-2 Main protease [PDF]
, 2023 Many homodimeric enzymes tune their function by exploiting either negative or positive cooperativity between subunits. In the SARS-CoV-2 Main protease (Mpro) homodimer, the latter has been suggested by symmetry in most of the 500 reported protease/ligand
Jörg Bernhard, Schulz +14 more
core +2 more sources
Cooperativity and Frustration Effects (or Lack Thereof) in Polarizable and Non-Polarizable Force Fields [PDF]
, 2023 Understanding cooperativity and frustration is crucial for studying biological processes, such as molecular recognition and protein aggregation. Force fields have been extensively utilized to explore cooperativity in the formation of protein secondary ...
Jean-Philip, Piquemal +3 more
core +2 more sources
Dicke-Cooperativity-Assisted Ultrastrong Coupling Enhancement in Terahertz Metasurfaces
, 2022 A system of N two-level atoms cooperatively interacting with a photonic field can be described as a single giant atom coupled to the field with interaction strength ∝N. This enhancement, known as Dicke cooperativity in quantum optics, has recently become
Amit Agrawal (314251) +10 more
core +1 more source
Nucleosome-mediated cooperativity between transcription factors [PDF]
, 2009 Cooperative binding of transcription factors (TFs) to cis-regulatory regions (CRRs) is essential for precision of gene expression in development and other processes.
Leonid A. Mirny, Mirny, Leonid A
core +1 more source
Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions. [PDF]
PLoS Genetics, 2013 p53 protects us from cancer by transcriptionally regulating tumor suppressive programs designed to either prevent the development or clonal expansion of malignant cells.
Katharina Schlereth +9 more
doaj +1 more source