Results 21 to 30 of about 58,890 (308)
Cooperation of RNA-Binding Proteins – a Focus on Roquin Function in T Cells
Frontiers in Immunology, 2022 Post-transcriptional gene regulation by RNA-binding proteins (RBPs) is important in the prevention of inflammatory and autoimmune diseases. With respect to T cell activation and differentiation, the RBPs Roquin-1/2 and Regnase-1 play pivotal roles by ...
Gesine Behrens +2 more
doaj +1 more source
Drug Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin [PDF]
, 2009 Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force.
Torres, Nuria Albet, +40 more
core +1 more source
p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo
Cell Reports, 2013 Four molecules of the tumor suppressor p53 assemble to cooperatively bind proapoptotic target genes. The structural basis for cooperativity consists of interactions between adjacent DNA binding domains.
Oleg Timofeev +8 more
doaj +1 more source
High Cooperativity Using a Confocal-Cavity–QED Microscope
PRX Quantum, 2023 Cavity quantum electrodynamics (QED) with cooperativity far greater than unity enables high-fidelity quantum sensing and information processing. The high-cooperativity regime is often reached through the use of short single-mode resonators.
Ronen M. Kroeze +4 more
doaj +1 more source
Cooperating with machines [PDF]
Nature Communications, 2018 AbstractSince Alan Turing envisioned artificial intelligence, technical progress has often been measured by the ability to defeat humans in zero-sum encounters (e.g., Chess, Poker, or Go). Less attention has been given to scenarios in which human–machine cooperation is beneficial but non-trivial, such as scenarios in which human and machine preferences
Jacob W. Crandall +9 more
openaire +10 more sources
Allosteric binding cooperativity in a kinetic context [PDF]
, 2023 Allosteric modulators are of prime interest in drug discovery. These drugs regulate the binding and function of endogenous ligands, with some advantages over orthosteric ligands.
Martín, Víctor +5 more
core +1 more source
Cooperative breeders do cooperate [PDF]
Behavioural Processes, 2007 Bergmuller et al. (2007) make an important contribution to studies of cooperative breeding and provide a theoretical basis for linking the evolution of cooperative breeding with cooperative behavior. We have long been involved in empirical research on the only family of nonhuman primates to exhibit cooperative breeding, the Callitrichidae, which ...
Snowdon, C., Cronin, K.
openaire +3 more sources
Relative Cooperativity in Neutral and Charged Molecular Clusters Using QM/MM Calculations [PDF]
, 2023 QM/MM methods have been used to study electronic structure properties and chemical reactivity in complex molecular systems where direct electronic structure calculations are not feasible. In our previous work, we showed that non-polarizable force fields,
G. Andrés, Cisneros +2 more
core +2 more sources
Molecules, 2019 A coinage-metal bond has been predicted and characterized in the complexes of [1.1.1]propellane (P) and M2/MCl/MCH3 (M = Cu, Ag, and Au). The interaction energy varies between −16 and −47 kcal/mol, indicating that the bridgehead carbon atom ...
Ruijing Wang, Shubin Yang, Qingzhong Li
doaj +1 more source
Measuring cis-regulatory energetics in living cells using allelic manifolds
eLife, 2018 Gene expression in all organisms is controlled by cooperative interactions between DNA-bound transcription factors (TFs), but quantitatively measuring TF-DNA and TF-TF interactions remains difficult.
Talitha L Forcier +5 more
doaj +1 more source