Results 101 to 110 of about 3,739,334 (352)

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Multi-source Directional Heat Conduction Method Based on Coordinate Transformation [PDF]

open access: gold, 2023
Yang Li   +4 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Calculation of unsteady transonic aerodynamics for oscillating wings with thickness [PDF]

open access: yes
An analytical approach is presented to account for some of the nonlinear characteristics of the transonic flow equation for finite thickness wings undergoing harmonic oscillation at sonic flight speed in an inviscid, shock-free fluid.
Ruo, S. Y., Theisen, J. G.
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Razvoj datumske transformacije med D48 in D96 z uporabo metode NTv2 (= Development of the datum transformation between the D48 and D96 using the NTv2 method) [PDF]

open access: yesGeodetski Vestnik
The Surveying and Mapping Authority of the Republic of Slovenia used a triangle-based transformation model for the entire country to transform between the old D48/GK and the current D96/TM coordinate reference systems.
Bojan Šavrič   +4 more
doaj   +1 more source

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