Results 81 to 90 of about 1,968,432 (294)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
On the symmetric transformation with geometric constraints
Geo-spatial Information ScienceCoordinate transformation is a fundamental issue in the related studies of measurement. However, existing methodologies often need to pay more attention to the available spatial information, leading to suboptimal results.
Wenxi Zhan +4 more
doaj +1 more source
Invisibility Cloak with Use of Nonsingular Coordinate Transformation [PDF]
Журнал нано- та електронної фізики, 2014 The non-singular coordinate transformation is investigated; the expressions for the components of permittivity and permeability are obtained. Numerical modelling of the corresponding object of invisibility was performed.
V.I. Vyunnik, A.A. Zvyagintsev
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Coordinate Transformation Resonators
, 2018 2-D coordinate transformation resonators based on transformation electromagnetics are proposed. The proposed resonators are with the shapes and effective media parameters coordinate transformed from arbitrary different shaped resonators.
Sanada, Atsushi +4 more
core
3D coordinate transformation using molodensky badekas transformation model: MBT07 [PDF]
, 2007 Transformations between coordinate systems are routinely carried out in surveying. As satellite positioning techniques are more frequently used, transformations of three-dimensional (3D) coordinates will become a common practice.
Phang, Seng Boon, Setan, Halim
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source