Results 81 to 90 of about 123,790 (304)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Analysis of coordinate transformation with different polynomial models [PDF]

open access: yes, 2017
The main task of geodesy is providing geodetic networks with fixed points in order to create a uniform geographical spatial reference frame as a fundament for the data collection by the official geodesy survey institutes.
Gao, Yueqing
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

APLIKASI PENENTUAN PARAMETER TRANSFORMASI LOKAL BATU HIJAU UNTUK SURVEI DAN PEMETAAN AREA TAMBANG PT. NEWMONT NUSA TENGGARA

open access: yesTeknik, 2012
Most of mining technical activities, especially survey and mapping use local reference system, including inmining area Batu Hijau of PT Newmont Nusa Tenggara.
Bambang Darmo Yuwono, Amin Marzuki
doaj  

Research on coordinate transformation of the three-phase circuit

open access: yes, 2013
The different three-phase circuit coordinate transformation matrixes are given in relevant literatures , which may cause some difficulties to understand and apply the coordinate transformation.
Xing, Tian Ming   +2 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Coordinate system connected with lower extremity and its application to knee impulsive force induced by landing after vertical fall

open access: yes, 2006
New coordinate system connected with the lower extremity is contrived and the transformation rule to such a coordinate system from any Cartesian coordinate system is derived.
畠中, 泰彦   +11 more
core  

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