Results 101 to 110 of about 1,968,432 (294)

On Relation between Hamada and Boozer Magnetic Coordinate System

, 1992
"The relation between the Hamada and the Boozer magnetic coordinate system is clarified by deriving them from a general magnetic field coordinate system.
"Nakajima, N., Okamoto, M.", Todoroki, J.   +2 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Second order two scale calculation for eigenvalue problem of porous material model in curvilinear coordinates

四川大学学报. 自然科学版, 2021
A second-order two-scale (SOTS) analysis method is developed for eigenvalue problems with quasi-periodic porous domain in curvilinear coordinates.
YE Shu-Yu, MA Qiang, HU Bing
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Residual-based neural network for unmodeled distortions in 2D coordinate transformation

Geodesy and Geodynamics
Coordinate transformation models often fail to account for nonlinear and spatially dependent distortions, leading to significant residual errors in geospatial applications.
Vinicius Francisco Rofatto, Luiz Felipe Rodrigues de Almeida, Marcelo Tomio Matsuoka, Ivandro Klein, Mauricio Roberto Veronez, Luiz Gonzaga Da Silveira, Junior   +5 more
doaj   +1 more source

Coordinate transformation parameters in Nepal by using neural network and SVD methods

Journal of Geodetic Science, 2019
The present study computes B-W extension model (extended Bursa-Wolf model) coordinate transformation parameters from World Geodetic System 1984 (WGS-84) to the Everest datum namely Everest (1830) and Everest (1956) using records of coordinate ...
Ansari Kutubuddin, Gyawali Prabin, Pradhan Prachand Man, Park Kwan-Dong   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

2-D Coordinate Transformation Based on Centre of Gravity Datum

, 2011
2-D Coordinate transformation between different coordinate system including four parameters: two translations, one rotation, and one scale factor parameter.
Li Luo, Tao Sheng Liu, Xian Gui Zeng, Sheng Xiang Huang   +3 more
core   +1 more source