Results 111 to 120 of about 481,621 (347)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Group VIII Coordination Chemistry of a Pincer-Type Bis(8-quinolinyl)amido Ligand [PDF]

, 2008
This paper provides an entry point to the coordination chemistry of the group VIII chemistry of the bis(8-quinolinyl)amine (BQA) ligand. In this context, mono- and disubstituted BQA complexes of iron, ruthenium, and osmium are described. For example, the
Betley, Theodore A., Peters, Jonas C., Qian, Baixin A.   +2 more
core  

Lattice-hydrogen cycling mechanism enables pH-universal hydrogen evolution at ampere-level current densities

Nature Communications
Controllable supply of hydrogen intermediate across a wide pH range is crucial for electroreduction reactions, but is hindered by pH-dependent hydrogen species formation on conventional catalysts.
Yan Zhang, Biao Feng, Jingyi Tian, Shiqi Zhou, Changkai Zhou, Yiqun Chen, Xiaoli Xia, Xizhang Wang, Lijun Yang, Luming Peng, Qiang Wu, Hongwen Huang, Zheng Hu   +12 more
doaj   +1 more source

Analysis of Photocatalytic Properties of Poly(Methyl Methacrylate) Composites with Titanium(IV) and Ruthenium(III) Complexes

Applied Sciences
This study explores poly(methyl methacrylate) (PMMA)-based composites as potential alternatives to conventional TiO2-based photocatalysts. Specifically, it examines PMMA composites enriched with oxo–titanium(IV) complexes, [Ti8O2(OiPr)20(man)4] (1 ...
Barbara Kubiak, Adrian Topolski, Aleksandra Radtke, Tadeusz Muzioł, Olga Impert, Anna Katafias, Rudi van Eldik, Piotr Piszczek   +7 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Hydro- and deutero-deamination of primary amines using O-diphenylphosphinylhydroxylamine

Nature Communications
While selective defunctionalizations are valuable in organic synthesis, hydrodeamination of primary amines poses challenges. Deuterodeamination, analogous to hydrodeamination, presents even greater difficulties due to its frequently slower deuteration ...
Panpan Ma, Ting Guo, Hongjian Lu
doaj   +1 more source

Cobalt-sulfur coordination chemistry drives B ₁₂ loading onto methionine synthase [PDF]

, 2023
Romila Mascarenhas, Arkajit Guha, Zhu Li, Markus Ruetz, Sojin An, Javier Seravalli, Ruma Banerjee   +6 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Is There a Negative Thermal Expansion in Supported Metal Nanoparticles? An In-Situ X-ray Absorption Study Coupled with Neural Network Analysis

, 2019
Interactions with their support, adsorbates and unique structural motifs are responsible for the many intriguing properties and potential applications of supported metal nanoparticles (NPs).
Ahmadi, M., Roldan Cuenya, B., Timoshenko, J.   +2 more
core   +1 more source