Results 71 to 80 of about 183,103 (313)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Seventeen‐Coordinate Actinide Helium Complexes [PDF]

Angewandte Chemie, 2017
AbstractThe geometries and electronic structures of molecular ions featuring He atoms complexed to actinide cations are explored computationally using density functional and coupled cluster theories. A new record coordination number is established, as AcHe173+, ThHe174+, and PaHe174+are all found to be true geometric minima, with the He atoms clearly ...
openaire   +4 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Spontaneous Ammonia Oxidation Through Coordination Induced Bond Weakening in Molybdenum Complexes of a Dianionic Pentadentate Ligand Platform

, 2022
Ammonia oxidation catalyzed by molecular compounds is of current interest as a carbon free source of dihydrogen. Activation of N-H bonds through coordination to transition metal centers is a key reaction in this process.
C. Christopher, Almquist, Benjamin, Gelfand, Laurent, Maron, Thayalan, Rajeshkumar, Nicole, Removski, Warren, Piers   +5 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

In-silico DFT studies and molecular docking evaluation of benzimidazo methoxy quinoline-2-one ligand and its Co, Ni, Cu and Zn complexes as potential inhibitors of Bcl-2, Caspase-3, EGFR, mTOR, and PI3K, cancer-causing proteins

Chemical Physics Impact
We present here the design, Density Functional Theory (DFT) and Molecular Docking studies of Benzimidazo Methoxy Quinoline-2-one (BMQ) ligand-coordinated transition metal complexes (Co, Ni, Cu, and Zn).
K Kaavin, D Naresh, MR Yogeshkumar, M Krishna Prakash, S Janarthanan, M Murali Krishnan, M Malathi   +6 more
doaj   +1 more source

Structural Study of Mismatched Disila-Crown Ether Complexes

Inorganics, 2017
Mismatched complexes of the alkali metals cations Li+ and Na+ were synthesized from 1,2-disila[18]crown-6 (1 and 2) and of K+ from 1,2,4,5-tetrasila[18]crown-6 (4).
Kirsten Reuter, Fabian Dankert, Carsten Donsbach, Carsten von Hänisch   +3 more
doaj   +1 more source

Syntheses, Crystal Structures and Antimicrobial Property of Schiff Base Copper(II) Complexes

Acta Chimica Slovenica, 2020
Four new copper(II) complexes, [CuL1(μ1,1-N3)]n (1), [CuL1(μ1,3-NCS)]n (2), [Cu(HL2)2](SCN)2 (3) and [Cu(L2)2] (4), where L1 and L2 are 2-((2-(dimethylamino)ethylimino)methyl-4,6-difluorophenolate and 2,4-difluoro-6-((3-morpholinopropylimino)methyl ...
Shun-Feng Yu, Xiao-Yang Qiu, Shu-Juan Liu   +2 more
doaj   +1 more source

Hydrated metal(II) complexes of N-(6-amino-3,4-dihydro-3-methyl-5-nitroso-4-oxopyrimidin-2-yl) derivatives of glycine, glycylglycine, threonine, serine, valine and methionine: a monomeric complex and coordination polymers in one, two and three dimensions linked by hydrogen bonding [PDF]

, 2004
Nine hydrated complexes of Group 2 (alkaline earth) cations with organic ligands which are N-substituted amino acids containing the 6-amino-3,4-dihydro-3-methyl-5-nitroso-4-oxopyrimidin-2-yl group have been structurally characterized.
Gallagher, John F., Gallagher, J F, Gutiérrez Valero, M. Dolores, Gallagher, JF, Arranz Mascarós, Paloma, Garzon, R L, Godino Salido, ML, Low, JN, Glidewell, C, Godino Salido, M. Luz, Low, J N, Gutiérrez Valero, MD, López Garzón, RLó, Salido, M L G, Arranz Mascarós, PAr, Low, John N., Mascaros, P A, López Garzón, Rafaél, Valero, M D G, Glidewell, Christopher   +19 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source