Interplay between uromodulin excretion and water balance in the general adult population [PDF]
Physiological Reports, Volume 14, Issue 7, April 2026.Abstract Uromodulin is a kidney‐specific protein that is excreted in the normal urine. Factors regulating its excretion are unknown. Conflicting studies suggest that water balance may influence uromodulin excretion which, in turn, may cooperate with vasopressin to increase water reabsorption in the distal nephron.
David A. Jaques +6 more
wiley +2 more sources
Interdialytic blood pressure is independent of weight gain and correlated with serum angiotensin II levels in adults [PDF]
Physiological Reports, Volume 14, Issue 9, May 2026.Abstract Chronic volume overload is a major risk factor of hypertension and mortality in chronic dialysis patients. However, the mechanisms responsible for hypertension are unclear. We studied 32 patients (age 23–68 years, 19 females) in chronic hemodiafiltration classified by their interdialytic ambulatory blood pressure (idABP, mmHg) in three groups:
Adolfo Diaz +5 more
wiley +2 more sources
Beyond “One‐Size‐Fits‐All”: Deconstructing the Hormonal Determinants of Sodium Sensitivity in Treated Hypertension [PDF]
J Clin Hypertens (Greenwich)The Journal of Clinical Hypertension, Volume 28, Issue 5, May 2026.
Dae‐Hee Kim
wiley +2 more sources
The Effect of Renal Function and Hemodialysis Treatment on Plasma Vasopressin and Copeptin Levels
Kidney International Reports, 2017 Copeptin is increasingly used in epidemiological studies as a substitute for vasopressin. The effect of renal function per se on copeptin and vasopressin concentrations as well as their ratio have, however, not been well described.
Esmée M. Ettema +8 more
doaj +3 more sources
Dietary Sodium Reduction Reveals Aldosterone Dysregulation in Patients With Essential Hypertension [PDF]
The Journal of Clinical Hypertension, Volume 28, Issue 3, March 2026.ABSTRACT Dietary sodium reduction affects blood pressure (BP), the renin‐angiotensin‐aldosterone system (RAAS) and natriuretic peptides. Whether baseline levels of these hormones impact BP response to sodium reduction remains unknown. Aldosterone dysregulation relates to higher cardiovascular risk, but the relation to sodium reduction has not been ...
Camilla L. Duus +4 more
wiley +2 more sources
Effects of sotagliflozin on markers of volume status and sodium handling in patients with type 1 diabetes: A biomarker analysis of the inTandem3 clinical trial [PDF]
Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3254-3263, April 2026.Abstract Aims Sotagliflozin, an inhibitor of sodium‐glucose co‐transporter (SGLT)‐1 and 2, reduces albuminuria, slows GFR decline, and may have diuretic and osmoregulatory effects. The effect of sotagliflozin added to insulin was assessed on markers of neurohormone activation and volume homeostasis in patients with type 1 diabetes (T1D).
Massimo Nardone +6 more
wiley +2 more sources
Association between copeptin levels and treatment responses to hypertonic saline infusion in patients with symptomatic hyponatremia: a prospective cohort study [PDF]
Kidney Research and Clinical Practice, 2021 Background Copeptin is secreted in equimolar amounts as arginine vasopressin, main hormone regulating body fluid homeostasis. A recent study reported a copeptin-based classification of osmoregulatory defects in syndromes of inappropriate antidiuresis ...
Suryeong Go +9 more
doaj +1 more source
Copeptin as an Indicator of Hemodynamic Derangement and Prognosis in Liver Cirrhosis. [PDF]
PLoS ONE, 2015 Advanced liver cirrhosis is associated with systemic hemodynamic derangement leading to the development of severe complications associated with increased mortality.
Annarein J C Kerbert +10 more
doaj +1 more source
Life, 2021 The prognostic value of copeptin in subarachnoid hemorrhage (SAH) has been reported, but the prognosis was largely affected by the initial clinical severity.
Jong Kook Rhim +6 more
doaj +1 more source
Changes in Plasma Copeptin Levels during Hemodialysis: Are the Physiological Stimuli Active in Hemodialysis Patients? [PDF]
PLoS ONE, 2015 Plasma levels of copeptin, a surrogate marker for the vasoconstrictor hormone arginine vasopressin (AVP), are increased in hemodialysis patients. Presently, it is unknown what drives copeptin levels in hemodialysis patients.
Esmée M Ettema +8 more
doaj +1 more source