Results 101 to 110 of about 15,782 (206)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, Volume 13, Issue 42, 28 July 2026.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Temporal Neuromuscular Adaptations and Proteomic Signatures Following Botulinum Neurotoxin A Injection in Spastic Hemiplegia Rats

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
In spastic hemiplegia rats, BoNT‐A (5 U/kg) improved motor function and reduced spasticity at 4 weeks post‐injection, but the efficacy had declined by 12 weeks. Proteomic analysis revealed 25 DEPs altered at both time points; Rtn1 and Sar1b were linked to synaptic regeneration.
Mengru Zhong, Huijuan Lin, Xubo Yang, Liru Liu, Yunlan Xie, Tingting Peng, Jie Luo, Lu He, Ting Gao, Hongmei Tang, Kaishou Xu   +10 more
wiley   +1 more source

Molecular Profiling of Extracellular Vesicles Isolated from Boar Reproductive Fluids

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
ABSTRACT Extracellular vesicles (EVs) are small membrane‐bound structures that facilitate intercellular communication in the reproductive system, modulating gamete maturation, capacitation, immunomodulation and fertilization. Despite pigs’ high relevance as a biomedical model, many aspects of EV biology remain poorly understood.
Veronika Kraus, Barbora Doleckova, Michaela Frolikova, Ondrej Sanovec, Daniela Spevakova, Zuzana Pilsova, Aneta Pilsova, Katerina Komrskova, Ondrej Simonik, Pavla Postlerova   +9 more
wiley   +1 more source

Is There a COPII‐Mediated Membrane Traffic in Chloroplasts? [PDF]

Traffic, 2010
COPII proteins facilitate membrane transport from the endoplasmic reticulum (ER) to the Golgi. They are highly conserved, although there are variations in their subcellular localization across plant, animal and yeast cells. Such variations may be needed to suit the unique organization of the ER and Golgi in the different cell systems.
openaire   +2 more sources

Depistarea tuberculozei la copii [PDF]

, 2011
În total 788 de cazuri TB la copii au fost raportate în mun. Chişinău în perioada anilor 1994 - 2008. S-a constatat, că la 24,6% de copii TB a fost depistată prin adresare şi la 75,4% prin control profi lactic.
Vîlc, Valentina
core  

Particularitățile adenomului și cancerului folicular al glandei tiroide la copii

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019
Au fost cercetate – particularitățile adenomului și cancerului folicular al glandei tiroide la copii în perioada anilor 2002-2018. Au fost supuși tratamentului chirurgical 31 de copii cu cancer folicular al glandei tiroide și 42 copii cu adenom folicular.
Andrei Ţîbîrnă, Gheorghe Ţîbîrnă, Silvia Railean, Aurelia Spinei, G. Guțul   +4 more
doaj  

Carbohydrate- and conformation-dependent cargo capture for ER-exit [PDF]

, 2005
Some secretory proteins leave the endoplasmic reticulum (ER) by a receptor-mediated cargo capture mechanism, but the signals required for the cargo-receptor interaction are largely unknown.
Appenzeller-Herzog, C., Lopez-Otin, C., Santamaria, I., Nyfeler, B., Burkhard, P., Hauri, H. -P.   +5 more
core   +1 more source

Jucării pentru copii [PDF]

, 2016
Fișierul atașat conține: Cuprins, Rezumat, Abstract.Prezentul proiect de licență: Design-concept ”Mobilier pentru camera de copii” studiază posibilitatea proiectării unui obiect de mobilier care sa satisfaca mai multe necesitati a copilului: de șezut și ...
FĂRÎMĂ, Sabina
core   +1 more source

The Structures of COPII Coats and Cages

The FASEB Journal, 2009
Coat protein complex II (COPII) vesicles are responsible for packaging and transporting over 10,000 different cargo molecules (about one‐third of the eukaryotic genome) of widely varying sizes and shapes from the endoplasmic reticulum (ER) to downstream compartments of the secretory pathway.
Scott Malone Stagg, Paul LaPointe, Abbas Razvi, Cemal Gurkan, Clinton S Potter, Bridget Carragher, William E Balch   +6 more
openaire   +1 more source

Tailored assemblies of COPII proteins in secretion

Journal of Cell Biology
Export of secretory cargoes from the endoplasmic reticulum (ER) requires COPII proteins, which were first identified for their ability to coat small vesicles that bud from the ER. Recent data indicate that COPII proteins can also organize into a collar at the necks of tubules, as well as phase-separate into liquid-like condensates.
openaire   +2 more sources