Results 81 to 90 of about 8,729 (179)

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, Volume 5, Issue 3, June 2026.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Is There a COPII‐Mediated Membrane Traffic in Chloroplasts? [PDF]

Traffic, 2010
COPII proteins facilitate membrane transport from the endoplasmic reticulum (ER) to the Golgi. They are highly conserved, although there are variations in their subcellular localization across plant, animal and yeast cells. Such variations may be needed to suit the unique organization of the ER and Golgi in the different cell systems.
openaire   +2 more sources

Particularitățile adenomului și cancerului folicular al glandei tiroide la copii

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019
Au fost cercetate – particularitățile adenomului și cancerului folicular al glandei tiroide la copii în perioada anilor 2002-2018. Au fost supuși tratamentului chirurgical 31 de copii cu cancer folicular al glandei tiroide și 42 copii cu adenom folicular.
Andrei Ţîbîrnă, Gheorghe Ţîbîrnă, Silvia Railean, Aurelia Spinei, G. Guțul   +4 more
doaj  

The Structures of COPII Coats and Cages

The FASEB Journal, 2009
Coat protein complex II (COPII) vesicles are responsible for packaging and transporting over 10,000 different cargo molecules (about one‐third of the eukaryotic genome) of widely varying sizes and shapes from the endoplasmic reticulum (ER) to downstream compartments of the secretory pathway.
Scott Malone Stagg, Paul LaPointe, Abbas Razvi, Cemal Gurkan, Clinton S Potter, Bridget Carragher, William E Balch   +6 more
openaire   +1 more source

Tailored assemblies of COPII proteins in secretion

Journal of Cell Biology
Export of secretory cargoes from the endoplasmic reticulum (ER) requires COPII proteins, which were first identified for their ability to coat small vesicles that bud from the ER. Recent data indicate that COPII proteins can also organize into a collar at the necks of tubules, as well as phase-separate into liquid-like condensates.
openaire   +2 more sources

Principles of COPII Coat Assembly

, 2021
Protein secretion in eukaryotic cells begins with COPII-mediated transport from the endoplasmic reticulum (ER). The COPII coat assembles on the cytoplasmic side of the ER membrane in consecutive stages. The inner coat comprises the Sar1-Sec23/Sec24 heterotrimeric complex and is recruited through the activation of the Sar1 GTPase.
openaire   +1 more source

Site-specific glycosylation of Sec24D and myoferlin recruit ERGIC to ER exit sites for collagen trafficking

Nature Communications
Coat protein complex II (COPII) mediates anterograde trafficking from the endoplasmic reticulum (ER). While the core COPII machinery is well-characterized, how cells regulate COPII to accommodate large cargoes, including collagens, remains incompletely ...
Tetsuya Hirata, Dharmendra Choudhary, Quyen Nguyen, Brittany J. Bisnett, Erik J. Soderblom, Ela W. Knapik, Michael Boyce   +6 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

In situ cryo-ET defines the ultrastructure of ER exit sites in human cells. [PDF]

Nat Cell Biol
Downes KW, Flood JR, Nans A, Van der Verren SE, Audhya A, Zanetti G.   +5 more
europepmc   +2 more sources