Results 81 to 90 of about 8,702 (177)

COPII Vesicles Get Supersized by Ubiquitin [PDF]

Cell, 2012
Some proteins are too big to fit into conventional COPII-coated vesicles, which raises the question of how large cargo, such as procollagen fibrils, are exported from the endoplasmic reticulum. Jin et al. (2012) in Nature now report that the creation of oversized vesicles is facilitated by the ubiquitination of the COPII component Sec31p.
openaire   +2 more sources

Mechanisms controlling the plasma membrane targeting and the nanodomain organization of the plant SPFH protein HIR2

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY Plasma membranes (PM) contain myriads of diverse nanodomains that correspond to nanometric scale structures enriched in specific lipids and proteins acting as signaling/regulation hubs involved in diverse biological processes. So far, how PM nanodomains are formed and maintained in plant cells remains largely unknown.
Michal Daněk, Omar Hdedeh, Jesús Amo, Jessica Boutet, Michaela Neubergerová, Héla Safi, Anas Abuzeineh, Amanda Martín‐Barranco, Jean‐Bernard Fiche, Caroline Mercier, Baldwin Dumortier, Gabriel Krouk, Marcelo Nollmann, Roman Pleskot, Yohann Boutté, Véronique Santoni, Sébastien Mongrand, Alexandre Martinière, Enric Zelazny   +18 more
wiley   +1 more source

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

An engineered epididymal cell line provides a sustainable source of functional extracellular vesicles for in vitro sperm preservation: A multi‐omics and functional study

VIEW, Volume 7, Issue 2, April 2026.
Schematic representation of the contribution of EVs proteins secreted by successfully established pEECs to sperm. pEECs‐derived EVs support sperm preservation in vitro through improved antioxidant capacity and viability, accompanied by reduced oxidative damage to membranes, mitochondria, DNA integrity and cell death.
Long Li, Haonan Zhao, Yibo Li, Qixin Xu, Yang Zi, Tingting Chu, Heran Cao, Shujuan Liu, Zifang Wu, Huanqiang Zhao, Wuzi Dong   +10 more
wiley   +1 more source

Is There a COPII‐Mediated Membrane Traffic in Chloroplasts? [PDF]

Traffic, 2010
COPII proteins facilitate membrane transport from the endoplasmic reticulum (ER) to the Golgi. They are highly conserved, although there are variations in their subcellular localization across plant, animal and yeast cells. Such variations may be needed to suit the unique organization of the ER and Golgi in the different cell systems.
openaire   +2 more sources

Particularitățile adenomului și cancerului folicular al glandei tiroide la copii

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019
Au fost cercetate – particularitățile adenomului și cancerului folicular al glandei tiroide la copii în perioada anilor 2002-2018. Au fost supuși tratamentului chirurgical 31 de copii cu cancer folicular al glandei tiroide și 42 copii cu adenom folicular.
Andrei Ţîbîrnă, Gheorghe Ţîbîrnă, Silvia Railean, Aurelia Spinei, G. Guțul   +4 more
doaj  

The Structures of COPII Coats and Cages

The FASEB Journal, 2009
Coat protein complex II (COPII) vesicles are responsible for packaging and transporting over 10,000 different cargo molecules (about one‐third of the eukaryotic genome) of widely varying sizes and shapes from the endoplasmic reticulum (ER) to downstream compartments of the secretory pathway.
Scott Malone Stagg, Paul LaPointe, Abbas Razvi, Cemal Gurkan, Clinton S Potter, Bridget Carragher, William E Balch   +6 more
openaire   +1 more source

Tailored assemblies of COPII proteins in secretion

Journal of Cell Biology
Export of secretory cargoes from the endoplasmic reticulum (ER) requires COPII proteins, which were first identified for their ability to coat small vesicles that bud from the ER. Recent data indicate that COPII proteins can also organize into a collar at the necks of tubules, as well as phase-separate into liquid-like condensates.
openaire   +2 more sources

Principles of COPII Coat Assembly

, 2021
Protein secretion in eukaryotic cells begins with COPII-mediated transport from the endoplasmic reticulum (ER). The COPII coat assembles on the cytoplasmic side of the ER membrane in consecutive stages. The inner coat comprises the Sar1-Sec23/Sec24 heterotrimeric complex and is recruited through the activation of the Sar1 GTPase.
openaire   +1 more source

The relationship between micronutrients and anthropometric measurements in malnourished children / Relaţia între micronutrienţi şi măsurătorile antropometrice la copiii malnutriţi

Romanian Journal of Laboratory Medicine, 2014
Scop: evaluarea nivelelor serice de micronutrienţi la copii cu tulburări de nutriţie, şi aprecierea corelaţiei dintre acestea şi măsurătorile antropometrice. Material şi metode: Studiul a fost realizat pe 125 copii (0-18 ani); lotul de lucru a constat în
Man Lidia, Man Adrian, Mărginean Cristina Oana, Pitea Ana Maria, Baghiu Maria Despina   +4 more
doaj   +1 more source