Results 91 to 100 of about 15,782 (206)

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, Volume 293, Issue 18, Page 5645-5663, September 2026.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Tumorile intracerebrale la copii [PDF]

, 2021
USMF„Nicolae Testemiţanu”, Catedra de neurochirurgie, ChișinăuIntroducere: Tumorile cerebrale ale sistemului nervos central pentru copii constituie (2,5-3,5 la 100 000 de copii anual), o parte importantă a practicii zilnice în oncologia pediatrică ...
Sula, Maxim, Litovcenco, Anatol, Bajurea, Ala   +2 more
core   +1 more source

SISTEMUL DE CLASIFICARE A FUNCŢIEI MOTORII GROSIERE ŞI SISTEMUL DE CLASIFICARE A ABILITĂŢII MANUALE ÎN EVALUAREA PARALIZIEI CEREBRALE [PDF]

Romanian Journal of Pediatrics, 2016
Paralizia cerebrală (PC) este o boală cerebrală cronică, definită ca un grup de afecţiuni motorii neprogresive care debutează în primul an de viaţă şi care sunt secundare leziunilor survenite la un creier aflat în dezvoltare.
Ioana Grigore, Georgeta Diaconu, Cătălin Prazaru, Alexandra Mania, Ana Ulinici   +4 more
doaj   +1 more source

SIB1‐SEC23A undergo ER to chloroplast relocalization to mediate immunity in Arabidopsis thaliana

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3458-3472, September 2026.
SEC23A mediates membrane trafficking between the endoplasmic reticulum (ER) and Golgi apparatus and interacts with the immunity protein SIGMA FACTOR‐BINDING PROTEIN1 in Arabidopsis. Under stress, both proteins relocate from the ER to chloroplasts, suppressing photosynthesis genes and enhancing defense genes.
Jialin Peng, Huan Zhong, Jianan Zhang, Hailei Zhang, Wuzhen Liu, Yonglun Zeng, Liwen Jiang, Yiji Xia   +7 more
wiley   +1 more source

Reconstituting the human COPII secretion system [PDF]

The human coat protein II (COPII) secretion system is an essential membrane trafficking system that exports cargo from the endoplasmic reticulum. While significant insight into the COPII secretion system has been gained using yeast as a model organism ...
Markova, Evgenia A.
core   +1 more source

COPILUL CU AFECŢIUNI ONCOLOGICE ÎN TERAPIA INTENSIVĂ [PDF]

Romanian Journal of Pediatrics, 2012
Progresele făcute în oncologie în decursul ultimilor ani au ameliorat considerabil prognosticul copiilor cu afecţiuni neoplazice. Ameliorarea supravieţuirii se însoţeşte însă de o creştere a riscului de complicaţii severe pentru care pacientul poate ...
N. Nistor, Georgiana Russu, Ingrith Miron, Irina-Mihaela Ciomaga, Cristina Jităreanu, Violeta Ştreangă   +5 more
doaj   +1 more source

Disruption of hippocampal upstream regulators of mTOR and insulin pathways in Down syndrome with Alzheimer's disease neuropathology: Preliminary observations

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Down syndrome (DS) is caused by a complete or partial trisomy of chromosome 21, resulting in variable intellectual disabilities and a high risk for early‐onset Alzheimer's disease (DS‐AD). Dysregulation of the mammalian target of rapamycin (mTOR) and insulin (INS) signaling pathways has been reported in DS.
Abigail J. Nordbeck, Mitchell Martá‐Ariza, Henric Ek Olofsson, Evgeny Kanshin, Beatrix Ueberheide, Ken Jones, Bridget Sanford, Eric D. Hamlett, Elizabeth Head, Elliott J. Mufson, Sylvia E. Perez, Thomas Wisniewski, Samuel Guzman, Ann‐Charlotte Granholm   +13 more
wiley   +1 more source

COPII Vesicles Get Supersized by Ubiquitin [PDF]

Cell, 2012
Some proteins are too big to fit into conventional COPII-coated vesicles, which raises the question of how large cargo, such as procollagen fibrils, are exported from the endoplasmic reticulum. Jin et al. (2012) in Nature now report that the creation of oversized vesicles is facilitated by the ubiquitination of the COPII component Sec31p.
openaire   +2 more sources

Interactive segmentation of membrane and membrane‐mimic densities in cryo‐EM maps

Acta Crystallographica Section D, Volume 82, Issue 8, Page 848-861, August 2026.
SURFER performs automated segmentation of contextual membrane and membrane‐mimic density in cryo‐EM maps to enable robust separation of macromolecular signal from surrounding detergent or lipid–membrane features. It is conveniently distributed as a plugin for UCSF ChimeraX, allowing interactive application within standard map‐visualization workflows ...
Alok Bharadwaj, Lotte Veerbeek, Arjen Jakobi   +2 more
wiley   +1 more source

Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4799-4822, August 2026.
ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng, Shuqin Zheng, Federica Brandizzi, Yiran Liu, Chunlei Li, Congcong Ai, Yujiao Wang, Jiadong Qi, Xiuguo Zhang   +8 more
wiley   +1 more source