Results 71 to 80 of about 8,729 (179)

EVALUARE EPIDEMIOLOGICĂ ŞI PSIHO-SOCIALĂ A COPILULUI OBEZ – STUDIU PROSPECTIV [PDF]

Romanian Journal of Pediatrics, 2016
Obiectiv. Studiul de faţă şi-a propus evaluarea unor parametri epidemiologici şi psiho-sociali într-un eşantion de copii supraponderali şi obezi spitalizaţi pentru diverse patologii. Durata studiului a fost de 12 luni. Material şi metodă.
Oana Elena Iaru, Raluca Maria Vlad, Marina Popov, Roxana Andrei, Irina Dijmărescu, Daniela Păcurar, Dumitru Orăşeanu   +6 more
doaj   +1 more source

Temporal Neuromuscular Adaptations and Proteomic Signatures Following Botulinum Neurotoxin A Injection in Spastic Hemiplegia Rats

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
In spastic hemiplegia rats, BoNT‐A (5 U/kg) improved motor function and reduced spasticity at 4 weeks post‐injection, but the efficacy had declined by 12 weeks. Proteomic analysis revealed 25 DEPs altered at both time points; Rtn1 and Sar1b were linked to synaptic regeneration.
Mengru Zhong, Huijuan Lin, Xubo Yang, Liru Liu, Yunlan Xie, Tingting Peng, Jie Luo, Lu He, Ting Gao, Hongmei Tang, Kaishou Xu   +10 more
wiley   +1 more source

COPII Vesicles Get Supersized by Ubiquitin [PDF]

Cell, 2012
Some proteins are too big to fit into conventional COPII-coated vesicles, which raises the question of how large cargo, such as procollagen fibrils, are exported from the endoplasmic reticulum. Jin et al. (2012) in Nature now report that the creation of oversized vesicles is facilitated by the ubiquitination of the COPII component Sec31p.
openaire   +2 more sources

Molecular Profiling of Extracellular Vesicles Isolated from Boar Reproductive Fluids

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
ABSTRACT Extracellular vesicles (EVs) are small membrane‐bound structures that facilitate intercellular communication in the reproductive system, modulating gamete maturation, capacitation, immunomodulation and fertilization. Despite pigs’ high relevance as a biomedical model, many aspects of EV biology remain poorly understood.
Veronika Kraus, Barbora Doleckova, Michaela Frolikova, Ondrej Sanovec, Daniela Spevakova, Zuzana Pilsova, Aneta Pilsova, Katerina Komrskova, Ondrej Simonik, Pavla Postlerova   +9 more
wiley   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

SISTEMUL DE CLASIFICARE A FUNCŢIEI MOTORII GROSIERE ŞI SISTEMUL DE CLASIFICARE A ABILITĂŢII MANUALE ÎN EVALUAREA PARALIZIEI CEREBRALE [PDF]

Romanian Journal of Pediatrics, 2016
Paralizia cerebrală (PC) este o boală cerebrală cronică, definită ca un grup de afecţiuni motorii neprogresive care debutează în primul an de viaţă şi care sunt secundare leziunilor survenite la un creier aflat în dezvoltare.
Ioana Grigore, Georgeta Diaconu, Cătălin Prazaru, Alexandra Mania, Ana Ulinici   +4 more
doaj   +1 more source

Metabolic Kinases as Regulators of Inter‐Organelle Communication in Aging and Age‐Related Diseases

Aging Cell, Volume 25, Issue 7, July 2026.
Metabolic kinases integrate cellular energy, nutrient, and stress signals to regulate inter‐organelle coordination during aging. In young or healthy cells, coordinated communication among mitochondria, the endoplasmic reticulum, lysosomes, peroxisomes, and the Golgi apparatus supports calcium handling, lipid metabolism, mitochondrial dynamics ...
Md Riad Chowdhury, Jae‐Han Jeon, Dipanjan Chanda   +2 more
wiley   +1 more source

COPILUL CU AFECŢIUNI ONCOLOGICE ÎN TERAPIA INTENSIVĂ [PDF]

Romanian Journal of Pediatrics, 2012
Progresele făcute în oncologie în decursul ultimilor ani au ameliorat considerabil prognosticul copiilor cu afecţiuni neoplazice. Ameliorarea supravieţuirii se însoţeşte însă de o creştere a riscului de complicaţii severe pentru care pacientul poate ...
N. Nistor, Georgiana Russu, Ingrith Miron, Irina-Mihaela Ciomaga, Cristina Jităreanu, Violeta Ştreangă   +5 more
doaj   +1 more source

From EM to AI: Multiscale imaging of the secretory pathway with insights from plant cells

Journal of Microscopy, Volume 303, Issue 1, Page 3-20, July 2026.
Abstract The secretory pathway is a central and evolutionarily conserved feature of eukaryotic cells, responsible for protein and lipid trafficking, membrane biogenesis, signalling, and cellular homeostasis. Its complexity, dynamic behaviour, and nanoscale organisation have made it a longstanding target of microscopy‐driven investigation.
Charlotte Pain, Emily Farley
wiley   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, Volume 13, Issue 36, 29 June 2026.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source