Results 61 to 70 of about 8,729 (179)

SINDROM ADRENOGENITAL LA NOU-NĂSCUT [PDF]

Romanian Journal of Pediatrics, 2013
Deshidratarea acută severă la sugar poate să survină în contextul unor multiple cauze etiologice, cea mai frecventă fi ind gastroenterita acută. Rezistenţa la tratamentul de corecţie electrolitic şi acidobazic prin persistenţa hiponatremiei alături de ...
Alina Murgu, Cătălina Ionescu, F. Cristogel, Adriana Baltag, Cezarina Dragomirescu, Evelina Moraru   +5 more
doaj   +1 more source

Pancreatic beta cell ER export in health and diabetes

Frontiers in Endocrinology, 2023
In the secretory pathway of the pancreatic beta cell, proinsulin and other secretory granule proteins are first produced in the endoplasmic reticulum (ER). Beta cell ER homeostasis is vital for normal beta cell functions and is maintained by the delicate
Cesar Barrabi, Kezhong Zhang, Ming Liu, Xuequn Chen   +3 more
doaj   +1 more source

Interactive segmentation of membrane and membrane‐mimic densities in cryo‐EM maps

Acta Crystallographica Section D, Volume 82, Issue 8, Page 848-861, August 2026.
SURFER performs automated segmentation of contextual membrane and membrane‐mimic density in cryo‐EM maps to enable robust separation of macromolecular signal from surrounding detergent or lipid–membrane features. It is conveniently distributed as a plugin for UCSF ChimeraX, allowing interactive application within standard map‐visualization workflows ...
Alok Bharadwaj, Lotte Veerbeek, Arjen Jakobi   +2 more
wiley   +1 more source

Assembly, organization, and function of the COPII coat [PDF]

Histochemistry and Cell Biology, 2007
A full mechanistic understanding of how secretory cargo proteins are exported from the endoplasmic reticulum for passage through the early secretory pathway is essential for us to comprehend how cells are organized, maintain compartment identity, as well as how they selectively secrete proteins and other macromolecules to the extracellular space.
Hughes, H, Stephens, DJ
openaire   +3 more sources

ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate

eLife, 2017
Native cargo proteins exit the endoplasmic reticulum (ER) in COPII-coated vesicles, whereas resident and misfolded proteins are substantially excluded from vesicles by a retention mechanism that remains unresolved.
Wenfu Ma, Elena Goldberg, Jonathan Goldberg   +2 more
doaj   +1 more source

Rabdomiosarcomul alveolar mimând leucemia acută la o adolescentă cu tromboză venoasă profundă – caz clinic [PDF]

Romanian Journal of Pediatrics, 2019
Rabdomiosarcomul este cel mai frecvent tip de sarcom al ţesuturilor moi şi se caracterizează prin invadarea şi distrugerea rapidă a ţesuturilor din vecinătate, tendinţa la metastazare fiind mare.
Daniela Vodă, Anca Corina Leonte, Carmen Oţelea, Anca Maria Ilea   +3 more
doaj   +1 more source

Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4799-4822, August 2026.
ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng, Shuqin Zheng, Federica Brandizzi, Yiran Liu, Chunlei Li, Congcong Ai, Yujiao Wang, Jiadong Qi, Xiuguo Zhang   +8 more
wiley   +1 more source

TUMORI ADRENOTESTICULARE LA UN ADOLESCENT CU SINDROM ADRENOGENITAL – REZULTATE DUPĂ UN AN [PDF]

Romanian Journal of Pediatrics, 2012
Introducere. Sindromul adrenogenital este o boală genetică care are ca rezultat producţia scăzută de cortizol şi aldosteron. Pacienţii de sex masculin cu sindrom adrenogenital pot prezenta tumori adrenotesticulare. Scop.
Adela Chiriţă, Ramona Cojocaru, Monica Marazan, Corina Duncescu, Ramona Stroescu, Bogdana Zoica, Ioana Micle   +6 more
doaj   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, Volume 13, Issue 42, 28 July 2026.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

COPII vesicles and the expansion of the phagophore

eLife, 2019
A new study has identified the proteins that adapt COPII vesicles to the needs of starving cells.
openaire   +5 more sources