Results 51 to 60 of about 5,675 (258)

Membrane Transporters as Mediators of Cisplatin Effects and Side Effects

Scientifica, 2012
Transporters are important mediators of specific cellular uptake and thus, not only for effects, but also for side effects, metabolism, and excretion of many drugs such as cisplatin.
Giuliano Ciarimboli
doaj   +1 more source

Characterization of the most frequent ATP7B mutation causing Wilson disease in hepatocytes from patient induced pluripotent stem cells [PDF]

, 2018
H1069Q substitution represents the most frequent mutation of the copper transporter ATP7B causing Wilson disease in Caucasian population. ATP7B localizes to the Golgi complex in hepatocytes but moves in response to copper overload to the endo-lysosomal ...
Allocca, Simona, Bonatti, Stefano, Ciano, Michela, Gallo, Maria, Iorio, Raffaele, Musto, Anna, Parisi, Silvia, Perone, Lucia, Polishchuk, Elena V, Polishchuk, Roman S, Ranucci, Giusy   +10 more
core   +2 more sources

A proteomic and phosphoproteomic analysis of Oryza sativa plasma membrane and vacuolar membrane [PDF]

, 2008
Proteomic and phosphoproteomic analyses of rice shoot and root tonoplast-enriched and plasma membrane-enriched membrane fractions were carried out to look at tissue-specific expression, and to identify putative regulatory sites of membrane transport ...
Ahn, Alexandersson, Armengaud, Banuelos, Benschop, Brugiere, Carter, Chrispeels, Ducos, Dunkley, Endler, Gaxiola, Gierth, Jacquinod, Komatsu, Larsson, Loque, Lüttge, Ma, Maathuis, Maathuis, Marmagne, Morsomme, Niittyla, Nühse, Nühse, Paszkowski, Peltier, Pighin, Rentsch, Sancenon, Tanaka, Tornroth-Horsefield, Toyofuku, Vitart, Whiteman, Wintz, Wu, Yazaki   +38 more
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper [PDF]

, 2013
The immunomodulatory and antimicrobial properties of zinc and copper have long been appreciated. In addition, these metal ions are also essential for microbial growth and survival.
Achard, Achouiti, Alastair G. McEwan, Aller, Andreini, Aydemir, Aydemir, Babu, Bao, Beck, Beker Aydemir, Bertinato, Besecker, Besecker, Bhutta, Bianchini, Botella, Boyne, Brazao, Brough, Camakaris, Cho, Cobbold, Corbin, Cousins, Crocker, Danks, Das, De Domenico, Failla, Fleming, Fraker, Fraker, Gaetke, Goode, Gray, Guilbert, Gunn, Gutteridge, Haase, Haase, Haase, Halfdanarson, Harris, Hodgkinson, Hood, Houghton, Huang, Humphrey, Idaghdour, Inoue, Inoue, Jones, Jones, Ke, Kelleher, Kirschke, Kitamura, Klomp, Klotz, Knoell, Kong, Kreuder, Kushner, Lastra, Lawson, Lee, Leibbrandt, Lemire, Lichten, Linz, Liu, Liuzzi, Liuzzi, Long, Lukacik, Lutsenko, Lutsenko, Maggini, Maret, Mark A. Schembri, Matthew J. Sweet, Maud E. S. Achard, Mazumder, McDevitt, Mehta, Meyer, Mocchegiani, Nairz, Newberne, Nilesh J. Bokil, Nowak, Osaki, Osaki, Osman, Overbeck, Palmiter, Pase, Patel, Patro, Paynter, Percival, Petris, Petris, Petris, Potter, Powell, Prasad, Prasad, Prasad, Prasad, Prasad, Prasad, Prasad, Prasad, Prohaska, Ramadori, Rink, Ronan Kapetanovic, Ryu, Salvin, Samanovic, Sandstead, Sayadi, Schroder, Seing, Sian L. Stafford, Singh, Snyder, Sobocinski, Sohnle, Steiger, Takano, Tamura, Turanov, Uzzo, Valavi, van den Berghe, Veldhuis, Visse, von Bulow, Voskoboinik, Vulpe, Wagner, Wardlaw, West, White, Wilson, Winters, Wirth, Xu, Yang, Yang, Yasuno, Yu, Yuen, Zaitsev, Zhou, Zhou   +158 more
core   +3 more sources

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

Advanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu   +10 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2015/16:Transporters [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
Aldrich, R, Alexander, SPH, Attali, B, Back, M, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Benson, HE, Biel, M, Birdsall, NJ, Boison, D, Brauner-Osborne, H, Broeer, S, Bryant, C, Burnstock, G, Burris, T, Cain, D, Calo, G, Chan, SL, Chandy, KG, Chiang, N, Christakos, S, Christopoulos, A, Chun, JJ, Chung, J-J, Clapham, DE, Connor, MA, Coons, L, Cox, HM, Dautzenberg, FM, Davies, JA, Dent, G, Douglas, SD, Dubocovich, ML, Edwards, DP, Faccenda, E, Farndale, R, Fong, TM, Forrest, D, Fowler, CJ, Fuller, P, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Grimm, SL, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hammond, JR, Hancox, JC, Hartig, S, Hauger, RL, Hay, DL, Hebert, T, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, GE, Jensen, R, Jetten, A, Jockers, R, Kaczmarek, LK, Kanai, Y, Kang, HS, Karnik, S, Kelly, E, Kerr, ID, Korach, KS, Lange, CA, Larhammar, D, Leeb-Lundberg, F, Leurs, R, Lolait, SJ, Macewan, D, Maguire, JJ, Marrion, N, May, JM, Mazella, J, McArdle, CA, McDonnell, DP, Michel, MC, Miller, LJ, Mitolo, V, Monie, T, Monk, PN, Mouillac, B, Murphy, PM, Nahon, J-L, Nerbonne, J, Nichols, CG, Norel, X, Oakley, R, Offermanns, S, Palmer, LG, Panaro, MA, Pawson, AJ, Perez-Reyes, E, Pertwee, RG, Peters, JA, Pike, JW, Pin, JP, Pintor, S, Plant, LD, Poyner, DR, Prossnitz, ER, Pyne, S, Ren, D, Richer, JK, Rondard, P, Ross, RA, Sackin, H, Safi, R, Sanguinetti, MC, Sartorius, CA, Segaloff, DL, Sharman, JL, Sladek, FM, Southan, C, Stewart, G, Stoddart, LA, Striessnig, J, Summers, RJ, Takeda, Y, Tetel, M, Toll, L, Trimmer, JS, Tsai, M-J, Tsai, SY, Tucker, S, Usdin, TB, Vilargada, J-P, Vore, M, Ward, DT, Waxman, SG, Webb, P, Wei, AD, Weigel, N, Willars, GB, Winrow, C, Wong, SS, Wulff, H, Ye, RD, Young, M, Zajac, J-M   +150 more
core   +4 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Bacterial resistance to arsenic protects against protist killing [PDF]

, 2017
Protists kill their bacterial prey using toxic metals such as copper. Here we hypothesize that the metalloid arsenic has a similar role. To test this hypothesis, we examined intracellular survival of Escherichia coli (E. coli) in the amoeba Dictyostelium
A Acland, Barry P. Rosen, C Neyt, C Pal, C Pal, C Pal, Chandan Pal, Christopher Rensing, D. G. Joakim Larsson, E Chi Fru, E Chi Fru, E Metchnikoff, F Amaro, F Tosetti, Hend A. Alwathnani, Jon Hobman, M Eppinger, N German, P Cosson, P Shannon, Quaiser Saquib, R Kapetanovic, X Hao, X Hao, Xiuli Hao, Xuanji Li, Yong-Guan Zhu   +26 more
core   +2 more sources