Results 31 to 40 of about 2,527 (168)

Reduced Neutrophil Extracellular Trap (NET) Formation During Systemic Inflammation in Mice With Menkes Disease and Wilson Disease: Copper Requirement for NET Release

Frontiers in Immunology, 2020
Neutrophil extracellular traps (NETs) contribute to pathological disorders, and their release was directly linked to numerous diseases. With intravital microscopy (IVM), we showed previously that NETs also contribute to the pathology of systemic ...
Iwona Cichon, Weronika Ortmann, Aleksandra Bednarz, Malgorzata Lenartowicz, Elzbieta Kolaczkowska   +4 more
doaj   +1 more source

Trafficking mechanisms of P-type ATPase copper transporters

Current Opinion in Cell Biology, 2019
Copper is an essential micronutrient required for oxygen-dependent enzymes, yet excess of the metal is a toxicant. The tug-of-war between these copper activities is balanced by chaperones and membrane transporters, which control copper distribution and availability. The P-type ATPase transporters, ATP7A and ATP7B, regulate cytoplasmic copper by pumping
Cortnie Hartwig, Stephanie A Zlatic, Melissa Wallin, Alysia Vrailas-Mortimer, Christoph J Fahrni, Victor Faundez   +5 more
openaire   +3 more sources

Rice Heavy Metal P-type ATPase OsHMA6 Is Likely a Copper Efflux Protein

Rice Science, 2020
P1B-type heavy metal ATPases (HMAs) are transmembrane metal-transporting proteins that play a key role in metal homeostasis. We here reported the characterization of rice OsHMA6, a member of the P1B-type ATPase family.
Zou Wenli, Li Chang, Zhu Yajun, Chen Jingguang, He Haohua, Ye Guoyou   +5 more
doaj   +1 more source

Role of the P-Type ATPases, ATP7A and ATP7B in brain copper homeostasis

Frontiers in Aging Neuroscience, 2013
Over the past two decades there have been significant advances in our understanding of copper homeostasis and the pathological consequences of copper dysregulation.
Jonathon eTelianidis, Ya Hui eHung, Stephanie eMateria, Sharon eLa Fontaine   +3 more
doaj   +1 more source

A comprehensive phylogenetic analysis of copper transporting P1B ATPases from bacteria of the Rhizobiales order uncovers multiplicity, diversity and novel taxonomic subtypes

MicrobiologyOpen, 2017
The ubiquitous cytoplasmic membrane copper transporting P1B‐1 and P1B‐3‐type ATPases pump out Cu+ and Cu2+, respectively, to prevent cytoplasmic accumulation and avoid toxicity.
Ciro Cubillas, Fabiola Miranda‐Sánchez, Antonio González‐Sánchez, José Pedro Elizalde, Pablo Vinuesa, Susana Brom, Alejandro García‐de los Santos   +6 more
doaj   +1 more source

Copper‐transporting ATPase is important for malaria parasite fertility [PDF]

Molecular Microbiology, 2013
SummaryHomeostasis of the trace element copper is essential to all eukaryotic life. Copper serves as a cofactor in metalloenzymes and catalyses electron transfer reactions as well as the generation of potentially toxic reactive oxygen species. Here, we describe the functional characterization of an evolutionarily highly conserved, predicted copper ...
Kenthirapalan, Sanketha, Waters, Andrew P., Matuschewski, Kai, Kooij, Taco W. A.   +3 more
openaire   +5 more sources

Expression of Menkes Copper-transporting ATPase, MNK, in the Lactating Human Breast: Possible Role in Copper Transport into Milk [PDF]

Journal of Histochemistry & Cytochemistry, 1999
The Menkes copper ATPase (MNK) is a copper efflux ATPase that is involved in copper homeostasis. Little is known about the intracellular localization and cell-specific function of the MNK in human tissues. To investigate a possible role for this protein in lactation, we measured its expression in sections of tissue from nonlactating and lactating ...
M L, Ackland, P, Anikijenko, A, Michalczyk, J F, Mercer   +3 more
openaire   +2 more sources

Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy [PDF]

Diabetologia, 2019
ATPase copper transporting α (ATP7A), also known as Menkes disease protein, is a P-type ATPase that transports copper across cell membranes. The critical role of ATP7A-mediated copper homeostasis has been well recognised in various organs, such as the intestine, macrophages and the nervous system.
Cong, Tao, Yajun, Wang, Ying, Zhao, Jianfei, Pan, Yiping, Fan, Xiaojuan, Liang, Chunwei, Cao, Jianguo, Zhao, Michael J, Petris, Kui, Li, Yanfang, Wang   +10 more
openaire   +2 more sources

Membrane Anchoring and Ion-Entry Dynamics in P-type ATPase Copper Transport [PDF]

Biophysical Journal, 2016
Cu+-specific P-type ATPase membrane protein transporters regulate cellular copper levels. The lack of crystal structures in Cu+-binding states has limited our understanding of how ion entry and binding are achieved. Here, we characterize the molecular basis of Cu+ entry using molecular-dynamics simulations, structural modeling, and in vitro and in vivo
Grønberg, Christina, Sitsel, Oleg, Lindahl, Erik, Gourdon, Pontus, Andersson, Magnus   +4 more
openaire   +7 more sources

A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity [PDF]

Journal of Biological Chemistry, 2009
Copper is an essential micronutrient that is necessary for healthy immune function. This requirement is underscored by an increased susceptibility to bacterial infection in copper-deficient animals; however, a molecular understanding of its importance in immune defense is unknown.
White, Carine, Lee, Jaekwon, Kambe, Taiho, Fritsche, Kevin, Petris, Michael J.   +4 more
openaire   +2 more sources