Results 21 to 30 of about 2,574 (179)

Rice Heavy Metal P-type ATPase OsHMA6 Is Likely a Copper Efflux Protein

Rice Science, 2020
P1B-type heavy metal ATPases (HMAs) are transmembrane metal-transporting proteins that play a key role in metal homeostasis. We here reported the characterization of rice OsHMA6, a member of the P1B-type ATPase family.
Zou Wenli, Li Chang, Zhu Yajun, Chen Jingguang, He Haohua, Ye Guoyou   +5 more
doaj   +1 more source

Role of the P-Type ATPases, ATP7A and ATP7B in brain copper homeostasis

Frontiers in Aging Neuroscience, 2013
Over the past two decades there have been significant advances in our understanding of copper homeostasis and the pathological consequences of copper dysregulation.
Jonathon eTelianidis, Ya Hui eHung, Stephanie eMateria, Sharon eLa Fontaine   +3 more
doaj   +1 more source

A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity [PDF]

Journal of Biological Chemistry, 2009
Copper is an essential micronutrient that is necessary for healthy immune function. This requirement is underscored by an increased susceptibility to bacterial infection in copper-deficient animals; however, a molecular understanding of its importance in immune defense is unknown.
White, Carine, Lee, Jaekwon, Kambe, Taiho, Fritsche, Kevin, Petris, Michael J.   +4 more
openaire   +2 more sources

Trafficking mechanisms of P-type ATPase copper transporters

Current Opinion in Cell Biology, 2019
Copper is an essential micronutrient required for oxygen-dependent enzymes, yet excess of the metal is a toxicant. The tug-of-war between these copper activities is balanced by chaperones and membrane transporters, which control copper distribution and availability. The P-type ATPase transporters, ATP7A and ATP7B, regulate cytoplasmic copper by pumping
Cortnie Hartwig, Stephanie A Zlatic, Melissa Wallin, Alysia Vrailas-Mortimer, Christoph J Fahrni, Victor Faundez   +5 more
openaire   +3 more sources

Expression of Menkes Copper-transporting ATPase, MNK, in the Lactating Human Breast: Possible Role in Copper Transport into Milk [PDF]

Journal of Histochemistry & Cytochemistry, 1999
The Menkes copper ATPase (MNK) is a copper efflux ATPase that is involved in copper homeostasis. Little is known about the intracellular localization and cell-specific function of the MNK in human tissues. To investigate a possible role for this protein in lactation, we measured its expression in sections of tissue from nonlactating and lactating human
M L, Ackland, P, Anikijenko, A, Michalczyk, J F, Mercer   +3 more
openaire   +2 more sources

Crystal structure of a copper-transporting PIB-type ATPase

Nature, 2011
Heavy-metal homeostasis and detoxification is crucial for cell viability. P-type ATPases of the class IB (PIB) are essential in these processes, actively extruding heavy metals from the cytoplasm of cells. Here we present the structure of a PIB-ATPase, a Legionella pneumophila CopA Cu(+)-ATPase, in a copper-free form, as determined by X-ray ...
Gourdon, Pontus Emanuel, Liu, Xiang-Yu, Skjørringe, Tina, Morth, J Preben, Møller, Lisbeth Birk, Pedersen, Bjørn Panyella, Nissen, Poul   +6 more
openaire   +3 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Copper‐transporting ATPase is important for malaria parasite fertility [PDF]

Molecular Microbiology, 2013
SummaryHomeostasis of the trace element copper is essential to all eukaryotic life. Copper serves as a cofactor in metalloenzymes and catalyses electron transfer reactions as well as the generation of potentially toxic reactive oxygen species. Here, we describe the functional characterization of an evolutionarily highly conserved, predicted copper ...
Kenthirapalan, Sanketha, Waters, Andrew P., Matuschewski, Kai, Kooij, Taco W. A.   +3 more
openaire   +5 more sources

PAA1, a P-Type ATPase of Arabidopsis, Functions in Copper Transport in Chloroplasts [PDF]

The Plant Cell, 2003
Copper (Cu) is an essential trace element with important roles as a cofactor in many plant functions, including photosynthesis. However, free Cu ions can cause toxicity, necessitating precise Cu delivery systems. Relatively little is known about Cu transport in plant cells, and no components of the Cu transport machinery in chloroplasts have been ...
Toshiharu, Shikanai, Patricia, Müller-Moulé, Yuri, Munekage, Krishna K, Niyogi, Marinus, Pilon   +4 more
openaire   +2 more sources

Membrane Transporters as Mediators of Cisplatin Effects and Side Effects

Scientifica, 2012
Transporters are important mediators of specific cellular uptake and thus, not only for effects, but also for side effects, metabolism, and excretion of many drugs such as cisplatin.
Giuliano Ciarimboli
doaj   +1 more source