Results 21 to 30 of about 2,527 (168)
Frontiers in Oncology, 2023 Currently, cancer has become one of the major public health problems worldwide. Apoptosis is an important anti-cancer defense mechanism, which is used in the development of targeted drugs.
Qianwen Zhao, Tonggang Qi
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Cancer Treatment and Research Communications, 2022 Drug resistance of cancer cells is a significant impediment to effective chemotherapy. One primary reason for this is copper exporters - ATPase copper transporting alpha (ATP7A) and ATPase copper transporting beta (ATP7B). These molecular pumps belong to
Prajit Janardhanan +3 more
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The Release Pathway of Copper Transporting Ptype ATPases [PDF]
Biophysical Journal, 2013 Cellular levels of heavy metals are carefully regulated by the PIB class of P-type ATPases in all kingdoms of life and mutations of the human members ATP7A and ATP7B are the cause of the severe Menkes' and Wilson's diseases. Recently, a crystal structure of a homologous Cu+ ATPase from Legionella pneumophila (LpCopA), trapped in a transition state of ...
Andersson, Magnus +5 more
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Copper Transporter ATP7A (Copper-Transporting P-Type ATPase/Menkes ATPase) Limits Vascular Inflammation and Aortic Aneurysm Development [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2019 Objective: Copper (Cu) is essential micronutrient, and its dysregulation is implicated in aortic aneurysm (AA) development. The Cu exporter ATP7A (copper-transporting P-type ATPase/Menkes ATPase) delivers Cu via the Cu chaperone Atox1 (antioxidant 1) to secretory Cu enzymes, such as lysyl oxidase, and excludes excess Cu.
Varadarajan, Sudhahar +15 more
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Responses in Micro-Mineral Metabolism in Rainbow Trout to Change in Dietary Ingredient Composition and Inclusion of a Micro-Mineral Premix. [PDF]
PLoS ONE, 2016 Responses in micro-mineral metabolism to changes in dietary ingredient composition and inclusion of a micro-mineral premix (Fe, Cu, Mn, Zn and Se) were studied in rainbow trout.
P Antony Jesu Prabhu +7 more
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Crystal Structure of the Human Copper Chaperone ATOX1 Bound to Zinc Ion
Biomolecules, 2022 The bioavailability of copper (Cu) in human cells may depend on a complex interplay with zinc (Zn) ions. We investigated the ability of the Zn ion to target the human Cu-chaperone Atox1, a small cytosolic protein capable of anchoring Cu(I), by a ...
Vincenzo Mangini +5 more
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International Journal of Microbiology, 2022 The genus Arthrobacter is a known group of Gram-positive, opportunistic pathogenic bacteria from cold climates, with members that are believed to play a variety of roles at low temperatures.
Jayram Karmacharya +4 more
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The Function of ATPase Copper Transporter ATP7B in Intestine [PDF]
Gastroenterology, 2018 Wilson disease is a disorder of copper (Cu) misbalance caused by mutations in ATP7B. ATP7B is highly expressed in the liver-the major site of Cu accumulation in patients with Wilson disease. The intestine also expresses ATP7B, but little is known about the contribution of intestinal ATP7B to normal intestinal copper homeostasis or to Wilson disease ...
Hannah, Pierson +6 more
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The YHS-Domain of an Adenylyl Cyclase from Mycobacterium phlei Is a Probable Copper-Sensor Module. [PDF]
PLoS ONE, 2015 YHS-domains are small protein modules which have been proposed to bind transition-metal ions like the related TRASH-domains. They are found in a variety of enzymes including copper-transporting ATPases and adenylyl cyclases.
Jürgen Ulrich Linder
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Frontiers in Microbiology, 2021 Copper (Cu)-transporting P1B-type ATPases are ubiquitous metal transporters and crucial for maintaining Cu homeostasis in all domains of life. In bacteria, the P1B-type ATPase CopA is required for Cu-detoxification and exports excess Cu(I) in an ATP ...
Andreea Andrei +12 more
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