Results 1 to 10 of about 2,574 (179)
Activity and Trafficking of Copper-Transporting ATPases in Tumor Development and Defense against Platinum-Based Drugs [PDF]
Cells, 2019 Membrane trafficking pathways emanating from the Golgi regulate a wide range of cellular processes. One of these is the maintenance of copper (Cu) homeostasis operated by the Golgi-localized Cu-transporting ATPases ATP7A and ATP7B.
Raffaella Petruzzelli +1 more
doaj +4 more sources
Biochemical basis of regulation of human copper-transporting ATPases [PDF]
Archives of Biochemistry and Biophysics, 2007 Copper is essential for cell metabolism as a cofactor of key metabolic enzymes. The biosynthetic incorporation of copper into secreted and plasma membrane-bound proteins requires activity of the copper-transporting ATPases (Cu-ATPases) ATP7A and ATP7B.
Svetlana Lutsenko
exaly +5 more sources
Gene Expression Analysis of Three Putative Copper-Transporting ATPases in Copper-Tolerant Fibroporia radiculosa [PDF]
Frontiers in Microbiology, 2020 Copper tolerance of brown-rot basidiomycete decay fungi can lessen the efficacy of copper-containing wood preservatives for wood products in-service. The purpose of this study was to evaluate wood mass loss and differential expression of three genes that
Katie M. Ohno +2 more
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Evolution of copper transporting ATPases in eukaryotic organisms. [PDF]
Curr Genomics, 2012 Copper is an essential nutrient for most life forms, however in excess it can be harmful. The ATP-driven copper pumps (Copper-ATPases) play critical role in living organisms by maintaining appropriate copper levels in cells and tissues. These evolutionary conserved polytopic membrane proteins are present in all phyla from simplest life forms (bacteria)
Gupta A, Lutsenko S.
europepmc +4 more sources
Structural basis of ion uptake in copper-transporting P1B-type ATPases
Nature Communications, 2022 P1B-type ATPases export excess transition metals from cells. Here, the authors report a molecular structure of CopA, a coppertransporting P1B-ATPase from A. fulgidus, in an inward-facing E1 conformation.
Nina Salustros +8 more
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IDEDNIK syndrome: a newly recognized rare genetic disorder caused by AP1S1 and AP1B1 mutations [PDF]
Frontiers in NeurologyIDEDNIK syndrome (formerly MEDNIK syndrome, OMIM #609313) is a rare autosomal recessive neurocutaneous disorder characterized by dysregulated copper metabolism and multisystem involvement. The primary causative gene, AP1S1, encodes the σ1A subunit of the
Rong Wu, Xingguang Luo, Xiao-Ping Wang
doaj +2 more sources
MicrobiologyOpen, 2017 The ubiquitous cytoplasmic membrane copper transporting P1B‐1 and P1B‐3‐type ATPases pump out Cu+ and Cu2+, respectively, to prevent cytoplasmic accumulation and avoid toxicity.
Ciro Cubillas +6 more
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Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B: Emerging roles [PDF]
International Journal of Biochemistry and Cell Biology, 2010 Copper (Cu) has a role in a diverse and increasing number of pathways, physiological and disease processes. These roles are testament to the fundamental importance of Cu in biology and the need to understand the mechanisms that regulate Cu homeostasis.
Sharon La Fontaine +2 more
exaly +3 more sources
Biochimica Et Biophysica Acta - BiomembranesHuman copper transporters ATP7B and ATP7A deliver copper to biosynthetic pathways and maintain copper homeostasis in the cell. These enzymes combine several challenges for structural biology because they are large low abundance membrane proteins with many highly mobile domains and long disordered loops.
Oleg Y Dmitriev, Jaala Patry
exaly +3 more sources
Frontiers in Oncology, 2023 Currently, cancer has become one of the major public health problems worldwide. Apoptosis is an important anti-cancer defense mechanism, which is used in the development of targeted drugs.
Qianwen Zhao, Tonggang Qi
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