Activity and Trafficking of Copper-Transporting ATPases in Tumor Development and Defense against Platinum-Based Drugs [PDF]
Cells, 2019 Membrane trafficking pathways emanating from the Golgi regulate a wide range of cellular processes. One of these is the maintenance of copper (Cu) homeostasis operated by the Golgi-localized Cu-transporting ATPases ATP7A and ATP7B.
Raffaella Petruzzelli +1 more
doaj +4 more sources
Biochemical basis of regulation of human copper-transporting ATPases. [PDF]
Arch Biochem Biophys, 2007 Copper is essential for cell metabolism as a cofactor of key metabolic enzymes. The biosynthetic incorporation of copper into secreted and plasma membrane-bound proteins requires activity of the copper-transporting ATPases (Cu-ATPases) ATP7A and ATP7B.
Lutsenko S, LeShane ES, Shinde U.
europepmc +6 more sources
Gene Expression Analysis of Three Putative Copper-Transporting ATPases in Copper-Tolerant Fibroporia radiculosa [PDF]
Frontiers in Microbiology, 2020 Copper tolerance of brown-rot basidiomycete decay fungi can lessen the efficacy of copper-containing wood preservatives for wood products in-service. The purpose of this study was to evaluate wood mass loss and differential expression of three genes that
Katie M. Ohno +2 more
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Evolution of copper transporting ATPases in eukaryotic organisms. [PDF]
Curr Genomics, 2012 Copper is an essential nutrient for most life forms, however in excess it can be harmful. The ATP-driven copper pumps (Copper-ATPases) play critical role in living organisms by maintaining appropriate copper levels in cells and tissues. These evolutionary conserved polytopic membrane proteins are present in all phyla from simplest life forms (bacteria)
Gupta A, Lutsenko S.
europepmc +4 more sources
Structural basis of ion uptake in copper-transporting P1B-type ATPases [PDF]
Nature Communications, 2022 P1B-type ATPases export excess transition metals from cells. Here, the authors report a molecular structure of CopA, a coppertransporting P1B-ATPase from A. fulgidus, in an inward-facing E1 conformation.
Nina Salustros +8 more
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IDEDNIK syndrome: a newly recognized rare genetic disorder caused by AP1S1 and AP1B1 mutations [PDF]
Frontiers in NeurologyIDEDNIK syndrome (formerly MEDNIK syndrome, OMIM #609313) is a rare autosomal recessive neurocutaneous disorder characterized by dysregulated copper metabolism and multisystem involvement. The primary causative gene, AP1S1, encodes the σ1A subunit of the
Rong Wu, Xingguang Luo, Xiao-Ping Wang
doaj +2 more sources
Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B: Emerging roles [PDF]
The International Journal of Biochemistry & Cell Biology, 2010 Copper (Cu) has a role in a diverse and increasing number of pathways, physiological and disease processes. These roles are testament to the fundamental importance of Cu in biology and the need to understand the mechanisms that regulate Cu homeostasis.
Sharon, La Fontaine +2 more
openaire +4 more sources
Crystal structure of a copper-transporting PIB-type ATPase
Nature, 2011 Heavy-metal homeostasis and detoxification is crucial for cell viability. P-type ATPases of the class IB (PIB) are essential in these processes, actively extruding heavy metals from the cytoplasm of cells. Here we present the structure of a PIB-ATPase, a Legionella pneumophila CopA Cu(+)-ATPase, in a copper-free form, as determined by X-ray ...
Gourdon, Pontus Emanuel +6 more
openaire +5 more sources
Nature CommunicationsCopper transporting P-type (P1B-1-) ATPases are essential for cellular homeostasis. Nonetheless, the E1-E1P-E2P-E2 states mechanism of P1B-1-ATPases remains poorly understood.
Zongxin Guo +10 more
doaj +2 more sources
The Plasma Membrane P-Type ATPase CtpA Is Required for Mycobacterium tuberculosis Virulence in Copper-Activated Macrophages in a Mouse Model of Progressive Tuberculosis [PDF]
BiomedicinesBackground/Objective: Finding new targets to attenuate Mycobacterium tuberculosis (Mtb) is key in the development of new TB vaccines. In this context, plasma membrane P-type ATPases are relevant for mycobacterial homeostasis and virulence.
Marcela López-Ruíz +6 more
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