Results 61 to 70 of about 6,768,795 (300)

Copper(II) Inhibition of the SARS-CoV-2 Main Protease [PDF]

, 2020
In an analysis of the structural stability of the coronavirus main protease (Mpro), we identified regions of the protein that could be disabled by cobalt(III)-cation binding to histidines and cysteines [1].
Roberto A., Garza-Lopez, Harry B., Gray, John J., Kozak   +2 more
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Copper(II) complexes of compartmental ligands: structural and stoichiometric aspects depending upon the anionic group of the copper salt [PDF]

, 2012
It has been found that anionic species of metal salts can lead to different geometries and stoichiometries in the synthesis of coordination compounds.
Medici, Serenella, Solinas, Costantino, Peana, Massimiliano Francesco, Zoroddu, Maria Antonietta   +3 more
core   +1 more source

On the interaction of copper( ii ) with disulfiram

Chem. Commun., 2014
The interaction of copper( ii ) ions with disulfiram, potentially important for new anticancer treatments, is explored under steady-state and kinetic conditions using a multi-spectroscopic approach which could lead to a deeper understanding of the mechanism of the reaction and may have ...
Lewis, David J.; id_orcid 0000-0001-5950-1350, Deshmukh, Parikshit, Tedstone, Aleksander, Tuna, Floriana; id_orcid 0000-0002-5541-1750, O'Brien, Paul   +4 more
openaire   +4 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Investigation of the solution chemistry and dermal absorption of novel copper (II) chelating agents that can serve as potential anti-inflammatory drugs [PDF]

, 2011
This study describes the investigation of the solution chemistry of the copper (II) complexes of homopiperazine and an adamentane derivative of homopiperazine (PCU.homo) using glass electrode potentiometry, UV/VIS spectroscopy, speciation modeling ...
Mokalane, Kagiso
core   +1 more source

Effect of Grafted Hydroquinone on the Acid-Base Properties of Poly(acrylic acid) in the Presence of Copper (II)

Journal of Chemistry, 2015
Potentiometric titration of poly(acrylic acid) and hydroquinone-functionalized poly(acrylic acid) was conducted in the presence of copper (II). The effects of hydroquinone functionalizing and copper (II) complexing on the potentiometric titration of poly(
Nabila Bensacia, Saâd Moulay, François Garin, Ioana Fechete, Anne Boos   +4 more
doaj   +1 more source

Copper(II)-Catalyzed Aminohydroxylation of Olefins [PDF]

Journal of the American Chemical Society, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
David J, Michaelis, Christopher J, Shaffer, Tehshik P, Yoon   +2 more
openaire   +2 more sources

Copper-infused fabric dampen inflammatory gene expression.

, 2023
(a) THP-1 human monocytic cells were differentiated into macrophages following incubation with 100 nM PMA overnight. Cells were then treated with 20 μM of copper(II) chloride dihydrate (CuCl2) or incubated with 100% leachate from copper-infused fabric ...
Khalil P. Chamoun (16993246), Yitian Tang (9395553), Gary Sweeney (332599), Khang Nguyen (12482510), Safoura Zangiabadi (16993243), Ali A. Abdul-Sater (6623273)   +5 more
core   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source