Results 41 to 50 of about 996,656 (308)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ChemistryOpen, 2019 The decomposition of copper formate clusters is investigated in the gas phase by infrared multiple photon dissociation of Cu(II)n(HCO2)2n+1−, n≤8. In combination with quantum chemical calculations and reactivity measurements using oxygen, elementary ...
Tobias F. Pascher +3 more
doaj +1 more source
The role of copper in disulfiram-induced toxicity and radiosensitization of cancer cells [PDF]
, 2013 <p>Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anti-cancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome ...
Ballangrud +8 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
‘Copper and Bronze in Art’ and the Search for Rare Corrosion Products
Heritage, 2023 The information taken from David A. Scott’s book “Copper and Bronze in Art” was crucial for this research on copper corrosion products in Stuttgart. The examples discussed are: (1) the nature and variability of ‘Black Spots’ (or ‘Brown Fuzzies’), mainly ...
Gerhard Eggert
doaj +1 more source
Biocompatible Copper Oxide Nanoparticle Composites from Cellulose and Chitosan: Facile Synthesis, Unique Structure, and Antimicrobial Activity [PDF]
, 2017 Copper in various forms has been known to have bactericidal activity. Challenges to its application include preventing mobilization of the copper, to both extend activity and avoid toxicity, and bioincompatibility of many candidate substrates for copper ...
Tran, Chieu D. +3 more
core +1 more source
Mononuclear Cu(II) complexes of novel salicylidene Schiff bases: synthesis and mesogenic properties [PDF]
, 2015 Two new Schiff base ligands 1 and 2 (where 1 = 4-(2-hydroxybenzilidenamino)-phenyl-4-(decyloxy)-2-(pent-4-enyloxy)benzoate, 2 = 4-(4-(decyloxy)-2-hydroxybenziliden amino)-phenyl-4-(decyloxy)-2-(pent-4-enyloxy)benzoate) and their copper (Cu)(II) complexes
Badea, Valentin +8 more
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Journal of Saudi Chemical Society, 2017 Dinuclear copper(II) complexes with formula [Cu2(L)2(N3)2] (1) and [Cu2(L)2(NCS)2] (2) HL = (1-[(3-methyl-pyridine-2-ylimino)-methyl]-naphthalen-2-ol) were synthesized by controlling the molar ratio of Cu(OAC)2·6H2O, HL, sodium azide (1) and ammonium ...
Madhumita Hazra +4 more
doaj +1 more source
Synthesis and sorption properties of filled fibrous sorbents with immobilized hetarylformazan groups [PDF]
, 2003 New sorbents were prepared by immobilization of structurally different sulfur-containing hetaryl-formazans on nonwoven polyacrylonitrile fiber tilled with AV-17 anion exchanger.
Lipunov, I. N. +4 more
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