Results 141 to 150 of about 267,849 (342)

Copper homeostasis in chronic kidney disease and its crosstalk with ferroptosis

Pharmacological Research
Chronic kidney disease (CKD) has become a global public health problem with high morbidity and mortality. Renal fibrosis can lead to end-stage renal disease (ESRD). However, there is still no effective treatment to prevent or delay the progression of CKD
Huang Jiayi, Tong Ziyuan, Xu Tianhua, Zhang Mingyu, Ma Yutong, Wang Jingyu, Zhou Hongli, Sun Li   +7 more
doaj   +1 more source

Investigation of in vivo measurement of cerebral cytochrome-c-oxidase redox changes using near-infrared spectroscopy in patients with orthostatic hypotension [PDF]

, 2007
We have previously used a continuous four wavelength near infrared spectrometer to measure changes in the cerebral concentrations of oxy- (Δ[HbO2] and deoxy- haemoglobin (Δ[HHb]) during head-up tilt in patients with primary autonomic failure.
Cooper, C.E., Delpy, D.T., Elwell, C.E., Leung, T.S., Smith, M., Tachtsidis, I., Tisdall, M.   +6 more
core  

Acute and sub-chronic effects of copper on survival, respiratory metabolism, and metal accumulation in Cambaroides dauricus [PDF]

, 2020
Jie Bao, Yuenan Xing, Chengcheng Feng, Shiyu Kou, Hongbo Jiang, Xiaodong Li   +5 more
openalex   +1 more source

Multiphysics‐Driven Assembly of Biomimetic Vesicles

Advanced Materials, EarlyView.
Artificial extracellular vesicles, derived from cell membranes, are manufactured using a multiphysics‐integrated microfluidic platform that combines nanoknife membrane rupture, herringbone chaotic mixing, and acoustothermal modulation. This standardizable workflow enables the predictable control of vesicle formation and therapeutic loading, while ...
Timofei Solodko, Ian Gimino, Aastha Chandiwala, Bayan Alkotoub, Ali Bashiri Dezfouli, Heiko Reith, Asjad Bakhtiar, Rojda Hicsanmaz, Johann Brenner, Christoph J. O. Kaiser, Elena Belli, Shilpi Pandey, Samuel D. Rabkin, Kornelius Nielsch, Gabriele Multhoff, Oliver Hayden, Morteza Hasanzadeh Kafshgari   +16 more
wiley   +1 more source

Microenvironment Modulation‐Based Nanomaterial‐Loaded Hydrogel Dressings for Diabetic Foot Ulcers: Research Progress and Future Perspectives

Advanced Materials Interfaces, EarlyView.
xx xx. ABSTRACT Diabetic foot ulcer (DFU) is a chronic complication of diabetes, primarily caused by hyperglycemia, peripheral vascular disease, and neuropathy. Characterized by persistent hyperglycemia, impaired perfusion, inflammation, and infection, DFUs pose significant challenges to healing and are associated with high morbidity and amputation ...
Tang Yuqing, Chen Hong, Fan Weijing, Huang Renyan, You Yang, Liu Guobin   +5 more
wiley   +1 more source

Cuproptosis promotes inflammatory osteolysis via GYS1-mediated glycogen metabolism

International Journal of Oral Science
Copper, predominantly present in bones, plays a crucial role in bone formation. However, when copper homeostasis is disrupted, excessive copper can trigger harmful inflammation and a novel form of cell death known as cuproptosis.
Lu Zhou, Hanqing Mao, Yuanhao Wen, Zhi Chen, Lu Zhang   +4 more
doaj   +1 more source

Two hydroxy pyridinecarboxylic acid derivatives as a possible chelating agents in neurodegenerative disease; equilibrium complexation studies with Cu(II), Zn(II). [PDF]

, 2014
The metal ion chelators 4-hydroxy-5-methyl-3-pyridinecarboxylic acid (DQ5) and 1,5-dimethyl-4-hydroxy-3-pyridinecarboxylic acid (DQ715) and Cu(II) and Zn(II) were investigated with the aim to restore the homeostasis of the brain Cu(II) and Zn(II) in ...
Dean, Annalisa, Di Marco, Valerio B., Gandin, Valentina, Jakusch, Tamás, Kiss, Tamás, Marzano, Christine, Nagy, Nóra Veronika, Sija, Éva   +7 more
core  

Copper Acts Synergistically With Fluconazole in Candida glabrata by Compromising Drug Efflux, Sterol Metabolism, and Zinc Homeostasis

, 2022
Ana Gaspar‐Cordeiro, Catarina Amaral, Vânia Pobre, Wilson Antunes, Ana Petronilho, Paulo Paixão, António Matos, Catarina Pimentel   +7 more
openalex   +1 more source

Enabling Real‐Time, Non‐Ionizing 3D Imaging of Implantable Magnetic Cements Using Magnetic Particle Imaging

Advanced Materials Interfaces, EarlyView.
This study reports the first implantable resin cement capable of orientation‐sensitive Magnetic Particle Imaging (MPI). By coating the cement with an ultrathin iron film, the authors achieve a strong, angle‐dependent MPI signal that enables non‐ionizing, real‐time tracking of both implant position and orientation, opening new possibilities for safe ...
Gabriel C. Pinto, João M. Costa, Simão P. Fernandes, Gabriela F. Resende, Eduardo T. C. Coimbra, Patrick Vogel, Mariana B. Oliveira, Marco Giardiello, Ricardo M. Silva, Armando A.C.S. Lourenço, Nuno J. O. Silva   +10 more
wiley   +1 more source

Copper death combination therapy: the innovative frontier and challenges in prostate cancer treatment

Cancer Biology & Therapy
Prostate cancer (PCA) remains a significant health challenge, necessitating the exploration of novel therapeutic strategies to enhance patient outcomes. Recent research has identified cuproptosis, a copper-dependent programmed cell death mechanism, as a ...
Jia Wei He, Pei Zhen Li, Zi Xuan Huang
doaj   +1 more source