Results 71 to 80 of about 264,643 (200)

Targeting copper metabolism to defeat KRAS-driven colorectal cancer

Molecular & Cellular Oncology, 2020
KRAS-driven cancers acquire profound metabolic dependencies that are intimately linked to tumor growth. Our work revealed that colorectal cancers that harbor KRAS mutations are addicted to copper metabolism. This adaptation renders tumor cells critically
Léo Aubert, Neethi Nandagopal, Philippe P. Roux   +2 more
doaj   +1 more source

Inborn errors of copper metabolism [PDF]

, 2013
Two copper-transporting ATPases are essential for mammalian copper homeostasis: ATP7A, which mediates copper uptake in the gastrointestinal tract and copper delivery to the brain, and ATP7B, which mediates copper excretion by the liver into bile. Mutations in ATP7A may cause three distinct X-linked conditions in infants, children, or adolescents ...
openaire   +2 more sources

Human whole-body copper metabolism [PDF]

The American Journal of Clinical Nutrition, 1998
Whole-body copper metabolism is difficult to study in human subjects. However, the use of isotopic tracers and kinetics modeling has added a dimension beyond what can be learned in humans by direct measurement. Mechanisms regulating total body copper seem to be strong, given the relatively small and constant body pool, but they are not yet well ...
openaire   +2 more sources

Severe Shock Caused by Rupture of Bladder Diverticulum in a Patient With Menkes Disease: A Case Report

Clinical Case Reports
Menkes disease (MD) is an X‐linked copper metabolism disorder associated with bladder diverticula (BD). BD in MD may easily perforate more than common BD because of connective tissue damage.
Shunsuke Fujii, Kouji Masumoto, Takahiro Jimbo, Yuichi Shibui, Takahiro Kido, Daisuke Hitaka, Hidetoshi Takada   +6 more
doaj   +1 more source

Costs of Chronic Waterborne Zinc Exposure and the Consequences of Zinc Acclimation on the Gill/Zinc Interactions of Rainbow Trout in Hard and Soft Water [PDF]

, 1999
Juvenile rainbow trout were exposed to zinc in both moderately hard water (hardness 5 120 mg CaCO3/L, pH = 8.0, Zn = 150 μg/L or 450 μg/L) and soft water (hardness = 20 mg CaCO3/L, pH = 7.2, Zn = 50 μg/L or 120 μg/L) for 30 d.
Alsop, Derek H., McDonald, D. Gordon, McGeer, James C., Wood, Chris M.   +3 more
core   +2 more sources

Bioavailability in soils [PDF]

, 2011
The consumption of locally-produced vegetables by humans may be an important exposure pathway for soil contaminants in many urban settings and for agricultural land use.
A Göthberg, A Marin, ACC Plette, AJ Maclean, AL Nolan, AL Nolan, B Buchter, BD Traulsen, BE Davies, BJ Alloway, BS Haslett, BS Shane, C Cobbett, CA Grant, CA Grant, CA Grant, CH Williams, CJ Cappon, CL Luo, CN Geng, CS Hassler, CS Hassler, D Sauerbeck, D Voutsa, DE Salt, DE Salt, DJ Brus, DJ Brus, DJ Brus, DJ Hatch, DM Toro Di, DR Parker, E Brand, E Grill, E Sipter, E Smolders, E Smolders, E Smolders, E Sposito, EA Woolson, EE Cary, EJJ Kalis, F Degryse, F Degryse, F Degryse, F Degryse, F Douay, F Haghiri, FJ Zhao, G Jansson, G Sposito, GA Fleming, GM Thomas, GP Warren, GT Yuran, H Mosbaek, HCH Hahne, IM McKenna, IO Plekhanova, J Ingwersen, JA Ericksen, JC Popelka, JC Tjell, JE Eriksson, JL Hall, JL Hopper, JL Wang, JL Xu, JM Gong, JR Preer, JR Preer, JR Wang, JW Dalenberg, JW Dalenberg, KC Jones, KG Tiller, KR Dunbar, LA Sparrow, LD Tyler, LL Hendrickson, LP Weng, LP Weng, M Helal, M Krauss, M Quaghebeur, M Sobotik, MB McBride, MF Hovmand, MI Mattina, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, ML Adams, MR Farfel, MTF Wong, NA Maier, NA Maier, OK Vatamaniuk, PD Alexander, PFAM Römkens, PJ Florijn, PJ Florijn, PJ Florijn, PJ Florijn, PMC Antunes, PMC Antunes, PR Anderson, Q Xue, R Hough, R Rellan-Alvarez, R Vogeli-Lange, RA Efroymson, RA Khattak, RH Dowdy, RJ Bowell, RJ Reid, RJM Hudson, RL Chaney, RL Chaney, RL Chaney, RL Hough, RL Hough, RM Harrison, RN Collins, RN Reese, RP Narwal, RT Checkai, S Clemens, S Goldberg, S Goldberg, S Sauvé, S Sauvé, S Tandy, S Tandy, S Thakali, SA Barber, SDW Comber, SE Lorenz, SL Brown, SL McGowen, SN Adams, SN Whiting, SP McGrath, T Adhikari, T Cheng, T Kuboi, T Sterckeman, TL Creger, V Page, W Peijnenburg, W Vries de, W Vries de, WJ Garcia, WP Chen, X Cao, X Du, XP Wang, Y Guo, Y Nakamaru, YT Guo   +164 more
core   +2 more sources

Investigation of relationships through which biodynamic growing practices affect plant growth and nutrient composition : a thesis presented in partial fulfilment of the requirements of the degree of Master of Science in Soil Science at Massey University [PDF]

, 2003
Author also known as Gillian Leslie ColeMore research attention has been paid to development of indicators of soil quality in relation to environmental sustainability than to food quality.
Bacchus, Gill
core  

Zebrafish mutants calamity and catastrophe define critical pathways of gene-nutrient interactions in developmental copper metabolism.

PLoS Genetics, 2008
Nutrient availability is an important environmental variable during development that has significant effects on the metabolism, health, and viability of an organism.
Erik C Madsen, Jonathan D Gitlin
doaj   +1 more source

Copper exposure and potential biomarkers of copper metabolism

Biometals, 2003
Relevant biological effects associated with mild to moderate copper deficiency and copper excess are unknown. It is difficult to identify markers of these early changes because limits of the homeostatic range are still undefined and early changes may represent adaptive responses that do not imply necessarily risk of damage.
Araya, M, Olivares, M, Pizarro, F, Gonzalez, M, Speisky, H, Uauy, R   +5 more
openaire   +6 more sources

Wilson's disease - clinical picture, factors influencing disease progression, treatment methods

Quality in Sport
Wilson's disease, also known as hepatolenticular degeneration, is a rare genetic metabolic disorder that leads to excessive accumulation of copper in the body, particularly in the liver and brain.
Monika Korga, Paweł Pawlik, Przemysław Zaroda, Jakub Wawrzkowicz, Patrycja Niewinna, Paweł Dąda, Dominika Mańdziuk , Michał Żuchowski, Klaudia Kołodziej , Wojciech Kołodziej    +9 more
doaj   +1 more source