Results 41 to 50 of about 9,837,393 (260)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Selections, frameshift mutations, and copy number variation detected on the gene in the western Kenyan population [PDF]

, 2017
Background: Plasmodium falciparum SURFIN4.1 is a putative ligand expressed on the merozoite and likely on the infected red blood cell, whose gene was suggested to be under directional selection in the eastern Kenyan population, but under balancing ...
Kaneko, A,, Ichinose, Yoshio, Yoshio Ichinose, Chan, CW, Yahata, Kazuhide, Gitaka, Jesse Njihia, Kaneko, Akira, Kaneko, Osamu, Akira Kaneko, Gitaka, JN, Francis W. Muregi, Kongere, James, Muregi, Francis W., Mika Takeda, Jesse N. Gitaka, Kongere, J, Kimura, Masatsugu, Chan, Chim W., Kazuhide Yahata, Idris, Zulkarnain Md, Chim W. Chan, Kimura, M, Zulkarnain Md Idris, Osamu Kaneko, Yahata, K, Gitaka, Jesse N., Masatsugu Kimura, James Kongere, Ichinose, Y, Takeda, Mika, Muregi, FW, Takeda, M, Idris, ZM   +32 more
core   +1 more source

Copy-number aberrations in mammary carcinomas from (SD×COP)F₁ rats.

, 2021
A, Chromosomal losses (green) and gains (red) in 21 tumors. Aberrations observed in the same carcinoma are arranged vertically, whereas those in different carcinomas are side by side.
Ikuya Tanaka (11272929), Maki Fukuda (11272926), Kazuhiro Daino (203837), Toshiaki Kokubo (11272941), Kazumasa Inoue (3701080), Masaru Takabatake (3202710), Mayumi Nishimura (455516), Shizuko Kakinuma (763026), Yoshiya Shimada (203843), Tatsuhiko Imaoka (455512), Masahiro Fukushi (3202707), Kaye Showler (11272935), Hitomi Moriyama (11272932), Yukiko Nishimura (11272938), Atsuko Ishikawa (11272944)   +14 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Copy number footprints of platinum-based anticancer therapies.

PLoS Genetics, 2023
Recently, distinct mutational footprints observed in metastatic tumors, secondary malignancies and normal human tissues have been demonstrated to be caused by the exposure to several chemotherapeutic drugs.
Santiago Gonzalez, Nuria Lopez-Bigas, Abel Gonzalez-Perez   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Copy number normalization distinguishes differential signals driven by copy number differences in ATAC-seq and ChIP-seq

BMC Genomics
A common objective across ATAC-seq and ChIP-seq analyses is to identify differential signals across contrasted conditions. However, in differential analyses, the impact of copy number variation is often overlooked.
Dingwen Su, Moritz Peters, Volker Soltys, Yingguang Frank Chan   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The Repertoire of Transfer RNA Genes Is Tuned to Codon Usage Bias in the Genomes of Phytophthora sojae and Phytophthora ramorum

Molecular Plant-Microbe Interactions, 2006
In all, 238 and 155 transfer (t)RNA genes were predicted from the genomes of Phytophthora sojae and P. ramorum, respectively. After omitting pseudogenes and undetermined types of tRNA genes, there remained 208 P. sojae tRNA genes and 140 P.
Sucheta Tripathy, Brett M. Tyler
doaj   +1 more source