Results 171 to 180 of about 502,320 (296)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Copy Number Variant Duplications Associated with Essential Tremor. [PDF]

Tremor Other Hyperkinet Mov (N Y)
Medeiros M, Liao C, Dilliott AA, Ross JP, Vuokila V, Aboasali F, Castonguay CE, Spiegelman D, Hopfner F, Vilariño-Güell C, García-Martín E, Alonso-Navarro H, Agúndez JAG, Jiménez-Jiménez FJ, Pastor P, Rajput A, Rajput A, Deuschl G, Kuhlenbäumer G, Girard SL, Farhan SMK, Dion PA, Rouleau GA.   +22 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout

Protein & Cell, 2017
Zheng Dong, Yuan Li, Jingru Zhou, Shuai Jiang, Yi Wang, Yulin Chen, Dongbao Zhao, Chengde Yang, Qiaoxia Qian, Yanyun Ma, Hongjun He, Hengdong Ji, Yajun Yang, Xiaofeng Wang, Xia Xu, Yafei Pang, Hejian Zou, Li Jin, Feng Zhang, Jiucun Wang   +19 more
doaj   +1 more source

Comprehensive Clinical, Diagnostic, and In Silico Assessment of a Novel 1p36.33p36.32 Copy Number Variant. [PDF]

J Cell Mol Med
Eslahi A, Kahaei MS, Shirvan BB, Alerasool M, Tabarestani S, Rezaie R, Hashemi N, Akhondian J, Arabi M, Ebrahimzadeh F, Toosi MB, Mojarrad M.   +11 more
europepmc   +1 more source

No signs of neurodegenerative effects in 15q11.2 BP1-BP2 copy number variant carriers in the UK Biobank. [PDF]

Transl Psychiatry, 2023
Boen R, Kaufmann T, Frei O, van der Meer D, Djurovic S, Andreassen OA, Selmer KK, Alnæs D, Sønderby IE.   +8 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Copy number variant analysis for syndromic congenital heart disease in the Chinese population. [PDF]

Hum Genomics, 2022
Li P, Chen W, Li M, Zhao Z, Feng Z, Gao H, Suo M, Xu Z, Tian G, Wu F, Wei S, Huang G.   +11 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Phenotypic spectrum of 11p15.5 duplications: parent-of-origin and copy number variant size shape outcomes from Silver-Russell to Beckwith-Wiedemann syndromes. [PDF]

Hum Genomics
Wang C, Zhang H, Wang M, Gao J, Lv Y, Huang J, Pan S, Wu D, Kang B, Hou Q, Liao S.   +10 more
europepmc   +1 more source