Results 181 to 190 of about 502,320 (296)

Prenatal counseling and the detection of copy-number variants [PDF]

Genetics in Medicine, 2013
openaire   +2 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Large-scale copy number variant analysis in genes linked to Parkinson´s disease. [PDF]

NPJ Parkinsons Dis
Landoulsi Z, Lohmann K, Vollstedt EJ, Wedgwood-Benn E, Niestroj LM, Laabs BH, Sendel S, Balck A, Borsche M, Lal D, Grünewald A, Brüggemann N, Franke A, Hicks A, Kasten M, Zeuner KE, Lange LM, Lieb W, Mollenhauer B, Pawlack H, Pramstaller PP, Caliebe A, König IR, May P, Klein C.   +24 more
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

A Cre-mediated copy number variant compromises the reliability of a <i>LoxP-STOP-LoxP</i>-<i>PLAG1</i> driven brain tumor model. [PDF]

Neurooncol Adv
Vaillant J, Pal S, Müller J, Wittmann A, Boakye-Yiadom A, Sievers P, Zimmer P, Schoof M, Schelb F, Hofmann N, Keck MK, Fabian T, Schüller U, Zuckermann M, Beroukhim R, Bandopadhayay P, Jones DTW, Kutscher LM.   +17 more
europepmc   +1 more source

Isolation of single circulating trophoblasts from maternal circulation for noninvasive fetal copy number variant profiling. [PDF]

Prenat Diagn, 2023
Doffini A, Forcato C, Mangano C, Lattuada D, Aversa R, Maranta C, Giovannone ED, Buson G, Bolognesi C, Maiocchi R, Dori M, Jamal L, Ahmad RB, Yeo GSH, Yeo TW, Saragozza S, Silipigni R, Serafini M, Biondi A, Perego S, Vergani P, Ferrazzi E, Ricciardi-Castagnoli P, Musci TJ, Grati FR.   +24 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Genome-wide copy number variant screening of Saudi schizophrenia patients reveals larger deletions in cases versus controls. [PDF]

Front Mol Neurosci, 2023
Abumadini MS, Al Ghamdi KS, Alqahtani AH, Almedallah DK, Callans L, Jarad JA, Cyrus C, Koeleman BPC, Keating BJ, Pankratz N, Al-Ali AK.   +10 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression. [PDF]

Mol Psychiatry
Xiong Y, Krebs K, Jermy B, Karlsson R, Pasman JA, Nguyen TD, Gong T, Kowalec K, Rück C, Sigström R, Jonsson L, Clements CC, Hörbeck E, Andersson E, Bäckman J, FinnGen, Estonian Biobank Research Team, Ganna A, German J, Sullivan PF, Landén M, Lehto K, Lu Y.   +22 more
europepmc   +1 more source