Results 111 to 120 of about 1,695,985 (356)

Glyoxalase 1 copy number variation in patients with well differentiated gastroentero-pancreatic neuroendocrine tumours (GEP-NET) [PDF]

, 2017
Background: The glyoxalase-1 gene (GLO1) is a hotspot for copy-number variation (CNV) in human genomes. Increased GLO1 copy-number is associated with multidrug resistance in tumour chemotherapy, but prevalence of GLO1 CNV in gastro-entero-pancreatic ...
Dimitriadis, Georgios K., Fisk, Adrian, Gopalakrishnan, Kishore, Grammatopoulos, Dimitris, James, Sean G., Kaltsas, Gregory, Qaiser, Talha, Rabbani, Naila, Rajpoot, Nasir M., Shafie, Alaa, Thornalley, Paul J., Weickert, Martin O., Xue, Mingzhan   +12 more
core   +1 more source

Environmental change drives accelerated adaptation through stimulated copy number variation

PLoS Biology, 2017
Copy number variation (CNV) is rife in eukaryotic genomes and has been implicated in many human disorders, particularly cancer, in which CNV promotes both tumorigenesis and chemotherapy resistance.
R. Hull, Cristina Cruz, Carmen V Jack, J. Houseley   +3 more
semanticscholar   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa

BMC Genomics, 2018
Background Gene copy number variants (CNVs), which consist of deletions and amplifications of single or sets of contiguous genes, contribute to the great diversity in the Plasmodium falciparum genome.
Joan Simam, Martin Rono, Joyce Ngoi, Mary Nyonda, Sachel Mok, Kevin Marsh, Zbynek Bozdech, Margaret Mackinnon   +7 more
doaj   +1 more source

Systematic identification of lincRNA‐based prognostic biomarkers by integrating lincRNA expression and copy number variation in lung adenocarcinoma

International Journal of Cancer, 2018
Copy number alterations (CNAs) of lincRNAs act as one of important mechanisms in disrupting lincRNA expression which may play critical roles during tumorigenesis in lung adenocarcinoma (LUAD). The copy number alterations of lincRNAs can mark the spectrum
Li Wang, Hongying Zhao, Yingqi Xu, Jing Li, Chunyu Deng, Yulan Deng, J. Bai, Xia Li, Yun Xiao, Yunpeng Zhang   +9 more
semanticscholar   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Automated copy number variation concordance analysis [PDF]

, 2021
Rapid growth and advancement of next generation sequencing (NGS) technologies have changed the landscape of genomic medicine. Today, clinical laboratories perform DNA sequencing on a regular basis, which is an error prone process.
Thapa Magar, Purushottam
core  

Adaptation by copy number variation increases insecticide resistance in fall armyworms

bioRxiv, 2019
Insecticide resistance is a major main challenge in pest control, and understanding its genetic basis is a key topic in agricultural ecology. Detoxification genes are well-known genetic elements that play a key role in adaptation to xenobiotics.
Kiwoong Nam, S. Gimenez, F. Hilliou, C. Blanco, Sabine Hänniger, A. Bretaudeau, F. Legeai, N. Negre, E. d’Alençon   +8 more
semanticscholar   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Finding Recurrent Regions of Copy Number Variation: A Review [PDF]

, 2008
Copy number variation (CNV) in genomic DNA is linked to a variety of human diseases, and array-based CGH (aCGH) is currently the main technology to locate CNVs.
Diaz-Uriarte, Ramon, Rueda, Oscar M.
core   +1 more source