Results 11 to 20 of about 255,296 (262)
2023 5th IEEE International Conference on Trust, Privacy and Security in Intelligent Systems and Applications (TPS-ISA), 2023 Cross-Origin Resource Sharing (CORS) is a mechanism to relax the security rules imposed by the Same-Origin Policy (SOP), which can be too restrictive for websites that rely on cross-site data exchange for their functioning. CORS allows trusting origins different from the website domain despite the presence of a strict SOP using a series of HTTP headers.
Golinelli, Matteo +3 more
openaire +1 more source
Journal of Arts, Humanities and Social ScienceCoastal flooding remains a recurring threat in the shoreline barangays of Digos City, where hazard exposure intersects with livelihood insecurity, weak infrastructure, and uneven institutional response. This study examines how residents of Aplaya, Cogon-
Jeremiah Blaise D. Andrade +12 more
doaj +1 more source
Revista Portuguesa de Pneumologia, 2011 Since digital thoracic drainage system (DTDS) came onto the market, a number of its advantages have become clear, for example that of eliminating the differences between observers.
J.M. Mier, J.J. Fibla, L. Molins
doaj +1 more source
Biomedicines, 2022 Background: Vertigo is an uncommon symptom among acute stroke victims. Knowledge about the clinical profile, the brain location, and the early outcome in stroke patients with cerebrovascular diseases and vertigo remains limited. Objectives: In this study,
Angela d’Annunzio +3 more
doaj +1 more source
Challenges and Coping Mechanisms of High School English Language Learners and their PISA Performance
International Journal of Multidisciplinary Educational Research and InnovationThis study explored the multifaceted experiences of high school English language learners (HS-ELLs) in a local public high school, focusing on their challenges, coping mechanisms, and institutional support systems.
Louise Jermie C. Pantig +6 more
doaj +1 more source
Frontiers in Physiology, 2023 Pulmonary vein isolation (PVI) is the most successful treatment for atrial fibrillation (AF) nowadays. However, not all AF patients benefit from PVI.
Carlos Fambuena-Santos +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source