Results 21 to 30 of about 2,825,849 (305)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Loculated empyema in a neonate successfully treated with chest tube thoracostomy and antibiotics
Respiratory Medicine Case Reports, 2020 Empyema thoracis, defined as the accumulation of pus in the pleural space, is a rare entity in the neonatal period. There are very few cases described in the medical literature and there are still no treatment protocols in the management of empyema in ...
John Robyn V. Diez +3 more
doaj +1 more source
Cor triatriatum sinister with situs inversus totalis in an infant. [PDF]
, 2012 Cor triatriatum sinister is a rare congenital cardiac malformation characterized by a membrane in the left atrium which separates the left atrium into the proximal and distal chambers.Association of cor triatriatum is extremely rare with situs inversus
Gadekar, A. +3 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Psicosomática y PsiquiatríaResumen: Introducción: La demencia por cuerpos de Lewy es una entidad neurológica de carácter degenerativo y progresivo que puede asociar clínica heterogénea: demencia, psicosis, alteraciones de la sensopercepción y de conducta, parkinsonismo, etc ...
Jaume Clemente Calvo +3 more
doaj +1 more source
The Experiences of Minority Immigrant Families Receiving Child Welfare Services: Seeking to Understand How to Reduce Risk and Increase Protective Factors [PDF]
, 2009 Wide recognition that families in the child welfare system experience multiple stressors has resulted in the development of a range of prevention and intervention strategies at individual, family, and policy levels.1 This article reports on a research ...
Alaggia, Ramona +2 more
core +3 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Scientific ReportsEfforts to optimize photosynthesis can be informed by measurement of it’s underlying and coordinated sub-processes. For decades, non-invasive techniques have been integrated to enable assessment of the coordination that exists within and between the ...
Thomas J. Avenson +3 more
doaj +1 more source
Chronic Respiratory Disease, 2009 The term “cor pulmonale” is still popular but there is presently no consensual definition and it seems more appropriate to define the condition by the presence of pulmonary hypertension (PH) resulting from diseases affecting the structure and/or the function of the lungs: PH results in right ventricular enlargement and may lead with time to right ...
E, Weitzenblum, A, Chaouat
openaire +2 more sources
Collision of One-Dimensional Nonlinear Chains
, 2002 We investigate one-dimensional collisions of unharmonic chains and a rigid wall. We find that the coefficient of restitution (COR) is strongly dependent on the velocity of colliding chains and has a minimum value at a certain velocity.
A.G. Basile +13 more
core +1 more source