Results 41 to 50 of about 3,498,597 (337)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

A model of Firm's Growth in a knowledge based economy [PDF]

, 2015
Knowledge-based economies use knowledge as an input of production to produce knowledge-intensive products and services. In such economies, a firm’s growth crucially depends on knowledge accumulation, technical change and the resulting innovation ...
Seddighi, Hamid
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

4-H Youth Development Professionals’ Perceptions of Youth Development Core Competence

Journal of Human Sciences and Extension, 2013
The purpose of this descriptive study was to assess the perceived level of competence among 4-H Youth Development Agents from a Southern state in the United States. The findings will be used to identify gaps in and opportunities for professional training
Janet E. Fox, Diane Sasser , Lisa Arcemont   +2 more
doaj   +1 more source

Training Family Science Faculty in CORE Communication [PDF]

, 2017
As a whole and regardless of major, university graduates with interpersonal competence (also defined as soft skills) are viewed as more employable (Finch, Hamilton, Baldwin, & Zehner, 2013; Robles, 2012), yet interpersonal competence is not often ...
Chen, Jou-Chen, Doudna, Kimberly Dawn, Duncan Lane, Crystal   +2 more
core   +1 more source

Investigation of L2/Ln Pragmatic Competence: Its Core and Route Map

Frontiers in Psychology, 2021
How to use language properly and acquire the capacity for language use has become the focus of linguists and philosophers for centuries. Therefore, pragmatic competence underlying language use arouses enormous interests of language acquisition ...
Tiaoyuan Mao
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Core competencies in Internal Medicine

European Journal of Internal Medicine, 2012
The working group on Competencies of Internal Medicine from the Spanish Society of Internal Medicine (SEMI) proposes a series of core competencies that we consider should be common to all European internal medicine specialists. The competencies include aspects related to patient care, clinical knowledge, technical skills, communication skills ...
Porcel J.M., Casademont J., Conthe P., Pinilla B., Pujol R., García-Alegría J.   +5 more
openaire   +6 more sources

Metaphoric competence and communicative language ability [PDF]

, 2006
Recent developments in cognitive linguistics have highlighted the importance as well as the ubiquity of metaphor in language. Despite this, the ability of second language learners to use metaphors is often still not seen as a core ability. In this paper,
Littlemore, Jeannette, Low, Graham
core