Results 41 to 50 of about 760,524 (299)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cultivating key disciplinary competencies among university students against the background of China's new engineering education initiative.

PLoS ONE
The development of students' core disciplinary competencies is crucial to the quality of talent cultivation against the background of China's New Engineering Education initiative.
Liyuan Zheng, Di Ge
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Muatan Materi Sastra dalam Buku Teks Bahasa Indonesia Kelas VIII Serta Relevansinya dengan Kompetensi Inti dan Kompetensi Dasar [PDF]

, 2018
This study aims to describe (a) the content of material literary contained in Indonesian textbooks class VIII (b) the relevance of material literary contained in the Indonesian textbooks class VIII with the Core Competence of Curriculum 2013, and (c) the
, Drs. Zainal Arifin, M. Hum, Kinasih, Dewi   +1 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

4-H Youth Development Professionals’ Perceptions of Youth Development Core Competence

Journal of Human Sciences and Extension, 2013
The purpose of this descriptive study was to assess the perceived level of competence among 4-H Youth Development Agents from a Southern state in the United States. The findings will be used to identify gaps in and opportunities for professional training
Janet E. Fox, Diane Sasser , Lisa Arcemont   +2 more
doaj   +1 more source

小学校教員養成のための外国語（英語）コア・カリキュラムの効果的運用 [PDF]

, 2017
According to the new core curriculum of English, communicative competence, especially the integration of five skills, is emphasized. It is essential for future teachers of elementary schools not only to learn how to instruct English, but also to acquire ...
井上 聡, 森下 裕三, 細井 健
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

An evolutionary stage model of outsourcing and competence destruction : a Triad comparison of the consumer electronics industry [PDF]

, 2008
Outsourcing has gained much prominence in managerial practice and academic discussions in the last two decades or so. Yet, we still do not understand the full implications of outsourcing strategy for corporate performance.
A. Chandler, A. O. Hirschman, B. Dankbaar, B. Nooteboom, B. Wernerfelt, D. J. Teece, D. J. Teece, D. J. Teece, F. T. Knickerbocker, G. Leroy, J. B. Barney, J. B. Quinn, J. H. Dunning, J. H. Dyer, K. Ferdows, M. A. Cusumano, M. E. Porter, M. G. Jacobides, M. J. Leiblein, M. J. Mol, M. Kenney, M. Kotabe, M. Kotabe, Masaaki Kotabe, Michael J. Mol, O. E. Williamson, R. A. D’Aveni, R. Bettis, R. Re, R. Vernon, S. J. Doig, S. J. Grossman, Sonia Ketkar, X. Dai, Y. L. Doz   +34 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source