Results 41 to 50 of about 80,937 (249)
Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more source5G Network Edge Intelligence for Smart Operation and Maintenance of Offshore Wind Power
SensorsAs global offshore wind power advances toward deeper, farther waters, harsh Operation and Maintenance (O&M) environments, equipment heterogeneity, and flaws in existing communication (e.g., insufficient 4G bandwidth, high-latency/cost satellite ...Yuqing Gao, Lingang Yang, Xialiang Zhu, Congxiao Jiang, Haoyu Wang, Shaonan You, Fangmin Xu +6 moredoaj +1 more sourceA novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz +9 morewiley +1 more sourceState-of-the-art survey on resource optimization in edge computing
大数据, 2019 The traditional centralized architecture,known as cloud computing,cannot accommodate such user demands in an efficient and timely manner.To cope with this problem,edge computing architectures have been proposed with the core concept of that“data ...Zhihao QU, Baoliu YE, Guihai CHEN, Bin TANG, Chenghao GUO +4 moredoaj Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan +13 morewiley +1 more sourceDIII-D research to provide solutions for ITER and fusion energy
Nuclear FusionThe DIII-D tokamak has elucidated crucial physics and developed projectable solutions for ITER and fusion power plants in the key areas of core performance, boundary heat and particle transport, and integrated scenario operation, with closing the core ...C.T. Holcomb, for the DIII-D Team:, J. Abbate, A. Abe, A. Abrams, P. Adebayo-Ige, S. Agabian, S. Ahmed, N. Aiba, N. Akcay, T. Akiyama, R. Albosta, P. Aleynikov, S. Allen, H. Anand, J. Anderson, Y. Andrew, M. Ashburn, A. Ashourvan, M. Austin, G. Avdeeva, D. Ayala, M. Ayub, E. Bagdy, S. Banerjee, K. Barada, L. Bardoczi, O. Bardsley, J. Barr, E. Bass, A. Battey, Z. Bayler, L. Baylor, T. Bechtel, M. Beidler, E. Belli, T. Benedett, Z. Bergstrom, M. Berkel, T. Bernard, N. Bertelli, R. Bielajew, G. Bodner, J. Boedo, R. Boivin, T. Bolzonella, P. Bonoli, A. Bortolon, S. Bose, M. Boyer, W. Boyes, L. Bradley, R. Brambila, A. Braun, D. Brennan, S. Bringuier, L. Brodsky, M. Brookman, J. Brooks, D. Brower, W. Brown, J. Buck, S. Buczek, D. Burgess, M. Burke, K. Burrell, J. Butt, R. Buttery, I. Bykov, P. Byrne, A. Cacheris, K. Callahan, J. Callen, D. Campbell, J. Candy, J. Canik, L. Cappelli, T. Carlstrom, R. Carr, W. Carrig, B. Carter, T. Carter, I. Carvalho, W. Cary, L. Casali, L. Ceelen, M. Cengher, M. Cha, R. Chaban, V. Chan, B. Chapman, I. Char, J. Chen, R. Chen, J. Chen, X. Chen, Y. Chen, J. Chiriboga, E. Cho, G. Choi, W. Choi, H. Choudhury, S. Chowdhury, C. Chrystal, Y. Chung, R. Churchill, R. Clark, M. Clement, J. Coburn, S. Coda, R. Coffee, C. Collins, J. Colmenares-Fernandez, W. Conlin, R. Coon, T. Cote, A. Creely, N. Crocker, C. Crowe, B. Crowley, T. Crowley, M. Curie, D. Curreli, A. Dal Molin, J. Damba, E. Dart, A. Dautt-Silva, K. Davda, A. De, N. de Boucaud, Y. de Jong, P. DE VRIES, A. de-Villeroche, G. DeGrandchamp, J. deGrassie, D. Demers, S. Denk, E. DeShazer, S. Di Genova, A. Diallo, A. Dimits, R. Ding, S. Ding, D. Donovan, X. Du, J. Dunsmore, A. Dupuy, J. Duran, A. Dvorak, F. Effenberg, N. Eidietis, D. Elder, D. Eldon, Y. Elsey, D. Ennis, K. Erickson, D. Ernst, M. Fajardo, H. Farre-Kaga, M. Fenstermacher, N. Ferraro, J. Ferron, A. Feyrer, P. Fimognari, R. Finden, D. Finkenthal, R. Fitzpatrick, S. Flanagan, B. Ford, W. Fox, S. Freiberger, L. Fu, K. Gage, V. Gajaraj, I. Garcia, F. Garcia, A. Garcia, M. Garcia Munoz, D. Garnier, A. Garofalo, A. Gattuso, B. Geiger, K. Gentle, Y. Ghai, K. Gill, F. Glass, P. Gohil, X. Gong, J. Gonzalez-Martin, Y. Gorelov, V. Graber, R. Granetz, C. Gray, C. Greenfield, B. Grierson, R. Groebner, W. Grosnickle, M. Groth, S. Gu, H. Guo, J. Guterl, W. Guttenfelder, R. Hager, S. Hahn, M. Halfmoon, J. Hall, V. Hall-Chen, F. Halpern, G. Hammett, X. Han, C. Hansen, E. Hansen, J. Hanson, M. Hanson, A. Harris, R. Harvey, S. Haskey, D. Hatch, W. Hayashi, A. Hayes, W. Heidbrink, J. Herfindal, J. Hicok, E. Hinson, T. Hisakado, C. Holcomb, C. Holland, L. Holland, E. Hollmann, A. Holm, I. Holmes, K. Holtrop, R. Hong, R. Hood, L. Horvath, S. Houshmandyar, N. Howard, E. Howell, W. Hu, Y. Hu, Q. Hu, Y. Huang, J. Huang, A. Huang, A. Hubbard, J. Hughes, D. Humphreys, J. Hurtado, A. Hyatt, K. Imada, V. Izzo, A. Jalalvand, S. Jardin, A. Jarvinen, Y. Jeon, H. Ji, X. Jian, L. Jian, Y. Jiang, C. Johnson, J. Johnson, M. Jones, S. Joung, P. Jouzdani, E. Jung, E. Kallenberg, R. Kalling, D. Kaplan, A. Kaptanoglu, D. Kellman, J. Kennedy, F. Khabanov, J. Kim, H. Kim, E. Kim, S. Kim, K. Kim, C. Kim, T. Kim, J. King, A. Kinsey, D. Kirk, D. Klasing, A. Kleiner, M. Knolker, M. Kochan, B. Koel, J. Koenders, M. Koepke, R. Kolasinski, E. Kolemen, E. Kostadinova, M. Kostuk, G. Kramer, R. Kube, N. Kumar, R. La Haye, F. Laggner, C. Lahban, H. Lan, R. Landry, R. Lantsov, L. Lao, C. Lasnier, C. Lau, R. Leccacorvi, J. Leddy, M. Lee, S. Lee, K. Lee, R. Lee, M. Lehnen, A. Leonard, E. Leppink, M. LeSher, J. Lestz, J. Leuer, N. Leuthold, G. Li, X. Li, Y. Li, L. Li, N. Li, Z. Li, D. Lin, Z. Lin, Z. Lin, Y. Lin, E. Linsenmayer, J. Liu, D. Liu, D. Liu, C. Liu, Z. Liu, Y. Liu, C. Liu, A. Loarte-Prieto, S. Loch, L. LoDestro, N. Logan, J. Lohr, J. Lore, U. Losada Rodriguez, J. Loughran, M. Lowell, T. Luce, N. Luhmann, P. Lunia, R. Lunsford, L. Lupin-Jimenez, A. Lvovskiy, B. Lyons, X. Ma, J. MacDonald, T. Macwan, R. Maingi, M. Major, L. Malhotra, M. Margo, C. Marini, A. Marinoni, A. Maris, E. Martin, J. Mateja, R. Mattes, R. Maurizio, D. Mauzey, L. McAllister, G. McArdle, J. McClenaghan, K. McCollam, G. McKee, K. McLaughlin, A. McLean, V. Mehta, E. Meier, S. Meitner, J. Menard, O. Meneghini, G. Merlo, S. Messer, W. Meyer, C. Michael, D. Miller, M. Miller, J. Mitchell, E. Mitra, C. Moeller, M. Mohamed, S. Molesworth, K. Montes, S. Mordijck, S. Morosohk, A. Moser, D. Mueller, S. Munaretto, C. Murphy, C. Muscatello, R. Myers, A. Nagy, D. Nath, M. Navarro, R. Nazikian, T. Neiser, A. Nelson, P. Nesbet, F. Nespoli, P. Nguyen, D. Nguyen, R. Nguyen, J. Nichols, M. Nocente, L. Nuckols, R. Nygren, T. Odstrcil, M. Okabayashi, E. Olofsson, D. Orlov, D. Orozco, N. Osborne, T. Osborne, F. OShea, D. Pace, D. Packard, A. Pajares Martinez, C. Pakosta, C. Pan, M. Pandya, D. Panici, A. Pankin, Y. Park, J. Park, J. Park, C. Parker, S. Parker, P. Parks, M. Parsons, S. Paruchuri, C. Paz-Soldan, T. Pederson, W. Peebles, B. Penaflor, E. Perez, L. Periasamy, R. Perillo, C. Petty, M. Pharr, D. Pierce, C. Pierren, S. Pierson, A. Pigarov, L. Pigatto, D. Piglowski, S. Pinches, R. Pinsker, R. Pitts, J. Pizzo, M. Podesta, Z. Popovic, M. Porkolab, Q. Pratt, G. Prechel, I. Pusztai, P. Puthan-Naduvakkate, J. Qian, X. Qin, O. Ra, T. Raines, K. Rakers, K. Rath, J. Rauch, C. Rea, R. Reed, A. Reiman, M. Reinke, R. Reksoatmodjo, Q. Ren, J. Ren, Y. Ren, M. Rensink, T. Rhodes, N. Richner, J. Ridzon, G. Riggs, J. Riquezes, P. Rodriguez Fernandez, T. Rognlien, G. Ronchi, L. Rondini, R. Rosati, A. Rosenthal, M. Ross, J. Rost, A. Rothstein, J. Roveto, J. Ruane, D. Rudakov, R. Rupani, G. Rutherford, S. Sabbagh, J. Sachdev, N. Sadeghi, A. Salmi, F. Salvador, B. Sammuli, C. Samuell, A. Sandorfi, C. Sang, D. Santa, J. Sarff, O. Sauter, H. Savelli, C. Schaefer, H. Schamis, J. Schellpfeffer, D. Schissel, L. Schmitz, O. Schmitz, P. Schroeder, K. Schultz, E. Schuster, F. Sciortino, F. Scotti, J. Scoville, A. Seltzman, J. Seo, J. Serrano, I. Sfiligoi, M. Shafer, R. Shapov, H. Shen, N. Shi, D. Shiraki, B. Short, R. Shousha, H. Si, C. Sierra, G. Sinclair, P. Sinha, G. Sips, C. Skinner, T. Slendebroek, J. Slief, R. Smirnov, S. Smith, D. Smith, G. Snoep, P. Snyder, W. Solomon, X. Song, A. Sontag, V. Soukhanovskii, D. Spong, J. Squire, G. Staebler, L. Stagner, T. Stange, P. Stangeby, E. Starling, S. Stewart, T. Stoltzfus-Dueck, S. Storment, E. Strait, D. Su, L. Sugiyama, P. Sun, Y. Sun, Y. Sun, X. Sun, C. Sung, W. Suttrop, Y. Suzuki, R. Sweeney, B. Taczak, Y. Takemura, S. Tang, S. Tang, W. Tang, G. Tardini, D. Taussig, K. Teixeira, K. Thackston, D. Thomas, K. Thome, Y. Tinguely, M. Tobin, J. Tooker, A. Torrezan de Sousa, P. Traverso, G. Trevisan, E. Trier, D. Truong, C. Tsui, F. Turco, A. Turnbull, L. Turner, E. Unterberg, B. Van Compernolle, R. van Kampen, M. Van Zeeland, B. Victor, R. Vieira, E. Viezzer, S. Vincena, D. Vollmer, J. Wai, M. Walker, R. Waltz, W. Wampler, L. Wang, Y. Wang, H. Wang, Z. Wang, G. Wang, A. Wang, J. Watkins, M. Watkins, T. Watts, L. Webber, K. Weber, W. Wehner, X. Wei, D. Weisberg, A. Welander, A. Welsh, A. White, R. Wilcox, G. Wilkie, T. Wilks, M. Willensdorfer, H. Wilson, A. Wingen, M. Wu, D. Wu, S. Wukitch, J. Xia, R. Xie, Z. Xing, G. Xu, X. Xu, Z. Yan, X. Yang, L. Yang, S. Yang, J. Yang, M. Yoo, G. YU, J. Yu, A. Zalzali, A. Zamengo, V. Zamkovska, S. Zamperini, K. Zarrabi, E. Zeger, K. Zeller, L. Zeng, X. Zhang, J. Zhang, B. Zhang, J. Zhang, B. Zhao, C. Zhao, Y. Zheng, Y. Zhu, J. Zhu, J. Ziegel, J. Zimmerman, C. Zuniga +667 moredoaj +1 more source
