Results 51 to 60 of about 80,937 (249)

Computational Architectures for 6G Networks: Integrating Distributed Computing and Edge Artificial Intelligence

Journal of Sensor and Actuator Networks
This paper investigates the integration of distributed computing and edge Artificial Intelligence (edge AI) as foundational enablers of sixth-generation (6G) mobile networks.
Evelio Astaiza Hoyos, Héctor Fabio Bermúdez-Orozco, Nasly Cristina Rodríguez-Idrobo   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

ESCNet: Edge-Semantics Collaborative Network With Multiscale Fusion for Land Cover Classification

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Land cover classification is a critical task in remote sensing image processing, with its core objective being the accurate classification of surface coverage through pixel-level feature extraction, thereby supporting applications such as environmental ...
Guangqi Xie, Jiawei Hu, Rui Tao, Zhiqi Zhang, Shenggu Yuan   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Integration of a CGRA Accelerator with a CVA6 RISC-V Core for the Cloud-edge Continuum

The computing continuum is a new paradigm that views the cloud, edge, and fog layers of the Internet of Things as part of a single space where computing tasks can be scheduled on various devices [1]. In this context, edge devices could benefit from application-class processors and reconfigurable accelerators to provide further adaptability and local ...
Otero, Andrés, Granja, Juan
openaire   +4 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

First integrated core-edge fluid simulation of ITER’s Limiter–Divertor transition with SolEdge-HDG

Nuclear Materials and Energy
This work explores the Limiter–Divertor transition (L–D) during the current ramp-up of ITER’s Q = 10 baseline plasma scenario at various central line-integrated density nli values. The analysis, based on transport simulations performed with the latest version of SoleEdge-HDG, focuses on the time evolution of heat and ion particle fluxes, revealing ...
D’abusco, M. Scotto, Kudashev, Ivan, Giorgiani, G., Glasser, Anna, Schwander, Frédéric, Serre, E., Bucalossi, J., Bufferand, H., Ciraolo, G., Tamain, P.   +9 more
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source