Results 51 to 60 of about 81,962 (290)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Simultaneous ELM suppression and divertor detachment via synergistic boron powder and neon injection in EAST

Nuclear Fusion
A novel approach for simultaneous power exhaust and edge-localized mode (ELM) control is presented in the Experimental Advanced Superconducting Tokamak discharges, which utilize an ITER-like tungsten divertor.
Zhen Sun, Rajesh Maingi, Wei Xu, Lei Peng, Kedong Li, Xin Lin, Yunxin Cheng, Donggui Wu, Fang Ding, Zhe Wang, Yanhong Guan, Minrui Wang, Yan Chao, Qingquan Yang, Kaifu Gan, Yuqiang Tao, Alessandro Bortolon, Huiqian Wang, Tianfu Zhou, Jia Huang, Wei Wang, Yifei Jin, Yanmin Duan, Yanzhen Xu, Ahmed Diallo, Kevin Tritz, Alexander Nagy, Hanna Schamis, Guizhong Zuo, Jinping Qian, Xianzu Gong, Jiansheng Hu, the EAST Team   +32 more
doaj   +1 more source

Service level agreement framework for differentiated survivability in GMPLS-based IP-over-optical networks [PDF]

, 2007
In the next generation optical internet, GMPLS based IP-over-optical networks, ISPs will be required to support a wide variety of applications each having their own requirements. These requirements are contracted by means of the SLA. This paper describes
Urra, A., Saud Albarrak, Harle, D.A., Ali, F., Marzo, J., Jose L. Marzo, Al-Barrak, S., Fuead Ali, Anna Urra, David Harle, Calle, E., Eusebi Calle   +11 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Advanced operation modes relying on core plasma turbulence stabilization in tokamak fusion devices

AAPPS Bulletin, 2023
Recent progress of advanced operation modes in tokamaks is addressed focusing upon internal transport barrier (ITB) discharges. These ITB discharges are being considered as one of candidate operation modes in fusion reactors.
Yong-Su Na
doaj   +1 more source

Information interoperability evaluation model for public web sites [PDF]

, 2006
The research project is based on the recently adopted European Interoperability Framework and its Spanish equivalent in order to design an evaluation model to identify key aspects related to information and knowledge interoperability in public ...
Martínez Usero, José Angel, Martínez Comeche, Juan Antonio, Beltrán Orenes, Pilar, San Segundo Manuel, Rosa, Beltrán Orenes, María Pilar   +4 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Impact of toroidal magnetic field direction on integrated ELM-stable operation and divertor power exhaust via boron powder injection in EAST

Nuclear Fusion
We report the first in-depth comparison of the impact of toroidal magnetic field direction on solid boron injection used for Edge-Localized Mode (ELM) control, power exhaust, and core high- Z impurity control in the Experimental Advanced Superconducting ...
Zhen Sun, Rajesh Maingi, Lei Peng, Xin Lin, Wei Xu, Zhe Wang, Qingquan Yang, Genfan Ding, Fang Ding, Kaifu Gan, Ahmed Diallo, Kevin Tritz, Tianfu Zhou, Yifeng Wang, Liang Chen, Kaixuan Ye, Wei Wang, Yunxin Cheng, Lingyi Meng, Yifei Jin, Ling Zhang, Yanmin Duan, Jizhong Sun, Alexander Nagy, Alessandro Bortolon, Guizhong Zuo, Jinping Qian, Xianzu Gong, Jiansheng Hu, the EAST Team   +29 more
doaj   +1 more source

Autonomous continuous flow reactor synthesis for scalable atom-precision

Carbon Trends, 2023
With new instrumentation design, robotics, and in-operando hyphenated analytical tool automation, the intelligent discovery of synthesis pathways is becoming feasible. It can potentially bridge the gap for the scale-up of new materials. We review current
Bobby G. Sumpter, Kunlun Hong, Rama K. Vasudevan, Ilia Ivanov, Rigoberto Advincula   +4 more
doaj   +1 more source