Results 81 to 90 of about 81,962 (290)

DIII-D research to provide solutions for ITER and fusion energy

open access: yesNuclear Fusion
The DIII-D tokamak has elucidated crucial physics and developed projectable solutions for ITER and fusion power plants in the key areas of core performance, boundary heat and particle transport, and integrated scenario operation, with closing the core ...
C.T. Holcomb   +667 more
doaj   +1 more source

Computational Architectures for 6G Networks: Integrating Distributed Computing and Edge Artificial Intelligence

open access: yesJournal of Sensor and Actuator Networks
This paper investigates the integration of distributed computing and edge Artificial Intelligence (edge AI) as foundational enablers of sixth-generation (6G) mobile networks.
Evelio Astaiza Hoyos   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

First integrated core-edge fluid simulation of ITER’s Limiter–Divertor transition with SolEdge-HDG

open access: yesNuclear Materials and Energy
This work explores the Limiter–Divertor transition (L–D) during the current ramp-up of ITER’s Q = 10 baseline plasma scenario at various central line-integrated density nli values. The analysis, based on transport simulations performed with the latest version of SoleEdge-HDG, focuses on the time evolution of heat and ion particle fluxes, revealing ...
D’abusco, M. Scotto   +9 more
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Low-rank matrix approximation with weights or missing data is NP-hard [PDF]

open access: yes
Weighted low-rank approximation (WLRA), a dimensionality reduction technique for data analysis, has been successfully used in several applications, such as in collaborative filtering to design recommender systems or in computer vision to recover ...
GILLIS, Nicolas, GLINEUR, François
core  

Analysis of motional eddy currents in the slitted stator core of an axial-flux permanent magnet machine [PDF]

open access: yes, 2020
This article concerns the modeling and design of a slitted stator core for single-sided axial-flux permanent-magnet machine application. The stator core is specially designed to maximize the magnetic-flux density in the air gap and to minimize the eddy ...
Gysen, Bart L.J.   +5 more
core   +1 more source

Home - About - Disclaimer - Privacy