Results 91 to 100 of about 80,937 (249)

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Core-edge integrated predictive studies of ST40 and NSTX plasmas with the scrape-off layer box model

Physics of Plasmas
The ability to model the interplay between the core and edge of tokamak plasmas is crucial to designing both the plasma operating scenario of a fusion pilot plant and the design of the tokamak itself. Scrape-off-layer (SOL) models that are tailored to integrated scenario modeling need to have fast turn-around time and minimal computational burden to ...
X. Zhang, N. A. Lopez, E. D. Emdee, F. M. Poli, T. O'Gorman, P. F. Buxton, C. Marsden, M. Moscheni, H. F. Lowe, A. Rengle   +9 more
openaire   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Study on Evolution Mechanism of Agricultural Trade Network of RCEP Countries—Complex System Analysis Based on the TERGM Model

Systems
The agricultural products trade network is essentially a complex adaptive system formed by nonlinear interactions between countries. Based on the complex system theory, this study reveals the dynamic self-organization law of the RCEP regional ...
Shasha Ding, Li Wang, Qianchen Zhou
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

LGNet: A Lightweight Ghost-Enhanced Network for Efficient SAR Ship Detection

Remote Sensing
Current SAR ship detection methods face a critical trade-off between accuracy and computational efficiency, severely limiting their deployment on resource-constrained edge devices that are essential for distributed maritime surveillance systems.
Jiawei Chen, Junyu Huang, Yuna Tan, Zhifeng Wu, Renbo Luo   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Compatibility of divertor detachment and ELM suppression in DIII-D high- plasmas with ITER-similar shape

Nuclear Fusion
Integration of transient and steady-state divertor heat fluxes control with a high-performance core is necessary for future fusion reactors. In recent DIII-D high- ${\beta _{\text{p}}}$ experiments, divertor detachment and simultaneous edge localized ...
D.G. Wu, L. Wang, H.Q. Wang, A.M. Garofalo, X.Z. Gong, S. Ding, Y.F. Wang, H. Lan, N. Yan, J. McClenaghan, D.B. Weisberg, A.W. Hyatt, T.H. Osborne, D. Eldon, M.E. Fenstermacher, F. Scotti, Q.Q. Yang, J. Huang, J.P. Qian, K.D. Li, J.B. Liu   +20 more
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source