Results 91 to 100 of about 81,962 (290)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Blockchain-Based Secure Storage Management with Edge Computing for IoT [PDF]

, 2019
As a core technology to manage decentralized systems, blockchain is gaining much popularity to deploy such applications as smart grid and healthcare systems.
Yunsick Sung, Baraka William Nyamtiga, Jong Hyuk Park, Shailendra Rathore, Jose Costa Sapalo Sicato   +4 more
core   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Automated Disassembly of Waste Printed Circuit Boards: The Role of Edge Computing and IoT

Computers
The ever-growing volume of global electronic waste (e-waste) poses significant environmental and health challenges. Printed circuit boards (PCBs), which form the core of most electronic devices, contain valuable metals as well as hazardous materials. The
Muhammad Mohsin, Stefano Rovetta, Francesco Masulli, Alberto Cabri   +3 more
doaj   +1 more source

SR4MEC: Enabling Flexible and Scalable Edge Computing in 5G Networks [PDF]

International audienceThe integration of edge computing with 5G networks is crucial to meeting the demands for low latency, and efficient resource utilization in modern applications. This paper introduces SR4MEC, an innovative architecture that leverages
Royer, Louis, Lavinal, Emmanuel, Chaput, Emmanuel   +2 more
core   +1 more source

MHD-stabilized reactor-relevant fusion plasmas (with full integration of edge, divertor and core) [PDF]

, 2020
Since 2013, the UNIST Fusion center has been studying the fusion plasma stability and confinement, while spearheading advanced imaging diagnostics [1]. This led us to directly measure the nonlinear interaction between resonant magnetic perturbation (RMP)
In, Yongkyoon, Yoon, Eisung, KIM, Kang-wook, YUN, Gunsu S   +3 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Integrating AI and cloud-edge technologies for music creation in educational and performance domains

Journal of Cloud Computing: Advances, Systems and Applications
This paper provides a systematic exploration of Artificial Intelligence (AI) for music generation within a cloud-edge synergy architecture (i.e. a coordinated cloud–edge computing paradigm where the cloud handles compute-intensive training and high ...
Xue Fan, Wei Zou, M. K. Moghimi, Wei Yi
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

HIS-TORIC: Extending core ICRF wave simulation to include realistic SOL plasmas [PDF]

This paper presents a novel approach to incorporating an arbitrarily shaped edge scrape-off-layer (SOL) plasma and an ion cyclotron range of frequency (ICRF) antenna structure into existing core ICRF wave simulation models.
S. Shiraiwa, J, C. Wright, J. P. Lee, P. Bonoli
core   +3 more sources