Results 51 to 60 of about 3,964,850 (349)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Understanding of double-curvature shaped magnetoimpedance profiles in Joule-annealed and tensioned microwires at 8-12 GHz

, 2014
We have investigated for the first time the combined effect of current and stress on the GMI characteristics of vanishing-magnetostrictive Co-rich microwires at microwave frequency.
Berzhansky, V. N., Gomonay, H. V., Popov, V. V., Qin, F. X.   +3 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Effective Field Theory and the No-Core Shell Model

EPJ Web of Conferences, 2010
In finite model space suitable for many-body calculations via the no-core shell model (NCSM), I illustrate the direct application of the effective field theory (EFT) principles to solving the many-body Schrödinger equation. Two different avenues for fixing
Stetcua I.
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The SPLASH Survey: A Spectroscopic Portrait of Andromeda's Giant Southern Stream [PDF]

, 2009
The giant southern stream (GSS) is the most prominent tidal debris feature in M31's stellar halo. The GSS is composed of a relatively metal-rich, high surface-brightness "core" and a lower metallicity, lower surface brightness "envelope." We present Keck/
Belokurov, Brown, Brown, Brown, Bullock, Bullock, Chapman, Chapman, Chou, Demarque, Durrell, Durrell, Evan N. Kirby, Fardal, Ferguson, Font, Font, Frebel, Fuhrmann, Gilbert, Gilbert, Gilbert, Guhathakurta, Guhathakurta, Holland, Ibata, Ibata, Jason S. Kalirai, Johnston, Kalirai, Kalirai, Karoline M. Gilbert, Kirby, Koch, Larson, Mackey, Majewski, Majewski, Majewski, Majewski, Marla C. Geha, Mori, Newberg, Newberg, Ostheimer, Palma, Priya Kollipara, Puragra Guhathakurta, Rachael L. Beaton, Richard J. Patterson, Richardson, Robertson, Rocha-Pinto, Schlegel, Shetrone, Shetrone, Simon, Sohn, Stanek, Steven R. Majewski, Tremaine, VandenBerg, Venn, Walterbos, White, Yanny   +65 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Fundamental Mechanism of Solar Eruption Initiation in a Multipolar Magnetic Field

The Astrophysical Journal, 2023
Recently, we established a fundamental mechanism of solar eruption initiation in which an eruption can be initiated from a bipolar field through magnetic reconnection in the current sheet (CS) that is formed slowly in the core field as driven by ...
Xinkai Bian, Chaowei Jiang, Xueshang Feng, Pingbing Zuo, Yi Wang   +4 more
doaj   +1 more source

Temperature distribution in magnetized neutron star crusts

, 2004
We investigate the influence of different magnetic field configurations on the temperature distribution in neutron star crusts. We consider axisymmetric dipolar fields which are either restricted to the stellar crust, ``crustal fields'', or allowed to ...
Arons, Baiko, Becker, Blandford, Buckley, Chanmugam, D. Page, Feroci, Flowers, Geppert, Greenstein, Haensel, Harding, Hernquist, Heyl, Heyl, Jones, Jones, Kouveliotou, Link, Lorenz, M. Küker, Negele, Page, Page, Page, Pons, Potekhin, Potekhin, Schaaf, Schaaf, Shibanov, Stairs, Stone, Svidzinsky, Thompson, Tsuruta, U. Geppert, Vasisht, Wiringa, Woltjer, Yakovlev   +41 more
core   +1 more source

Vacuum polarization by a global monopole with finite core [PDF]

, 2006
We investigate the effects of a $(D+1)$-dimensional global monopole core on the behavior of a quantum massive scalar field with general curvature coupling parameter.
A. Erdelyi ., A. Romeo, A. Vilenkin, A.A. Saharian, A.A. Saharian, A.A. Saharian, A.A. Saharian, A.P. Prudnikov, Aram A Saharian, D.D. Sokolov, E.R. Bezerra de Mello, Eugenio R. Bezerra de Mello, F.C. Carvalho, F.C. Carvalho, J. Spinelly, M. Abramowitz, N.D. Birrell, T. W. Kibble   +17 more
core   +2 more sources