Results 71 to 80 of about 893,570 (306)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Computation of core losses in electrical machines using improved models for laminated steel [PDF]

open access: yes, 2007
Two new models for specific power losses in cold-rolled motor lamination steel are described together with procedures for coefficient identification from standard multifrequency Epstein or single sheet tests.
Dellinger, S.J.   +5 more
core   +1 more source

Genesis of the formation of the cultural and social core of Odessa

open access: yesVitruvio: International Journal of Architectural Technology and Sustainability, 2018
The architectural and spatial environment of the city is an important part of the cultural heritage, a carrier of information about its formation. The life cycle of a diverse architectural environment forms a series of stages - from the concept-creation ...
Nadia Yeksarova, Vladimir Yeksarov
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

New silicon photonics integration platform enabled by novel micron-scale bends

open access: yes, 2013
Even though submicron silicon waveguides have been proposed for dense integration of photonic devices, to date the lightwave circuits on the market mainly rely on waveguides with micron-scale core dimensions.
Aalto, Timo   +4 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Short-wavelength transmission-loss suppression in fibre Bragg gratings

open access: yes, 1997
Fibre Bragg Gratings (FBGs) are known to suffer from short-wavelength, transmission losses due to resonant coupling into backward-propagating cladding modes. Figure 1 shows a typical transmission spectrum of a 10cm standard FBG.
Ibsen, M., Laming, R.I., Zervas, M.N.
core  

Thermally Pulsing Asymptotic Giant Branch Star Models and Globular Cluster Planetary Nebulae I: The Model

open access: yes, 2011
Thermally pulsing asymptotic giant branch models of globular cluster stars are calculated using a synthetic model with the goal of reproducing the chemical composition, core masses and other observational parameters of the four known globular cluster ...
Alexander   +56 more
core   +1 more source

Low-loss Multimoded Antiresonant Hollow Core Fiber

open access: yes14th Pacific Rim Conference on Lasers and Electro-Optics (CLEO PR 2020), 2020
We report the first design for low-loss, multimoded antiresonant hollow-core fiber for applications requiring multiple modes. The designed fiber guides 6 - 9 spatially distinct core modes having confinement loss <0.001 - 0.01dB/m respectively.
Goel, Charu, Yoo, Seongwoo
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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