Results 81 to 90 of about 893,570 (306)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Design of space-type electronic power transformers [PDF]

Both open and encapsulated varieties of high reliability, low weight, and high efficiency moderate and high voltage transformers were investigated to determine the advantages and limitations of their construction in the ranges of power and voltage ...
Ahearn, J. F., Lagadinos, J. C.
core   +1 more source

Bismuth ferrite as low-loss switchable material for plasmonic waveguide modulator [PDF]

, 2014
We propose new designs of plasmonic modulators, which can be utilized for dynamic signal switching in photonic integrated circuits. We study performance of plasmonic waveguide modulator with bismuth ferrite as an active material. The bismuth ferrite core
Babicheva, Viktoriia E., Lavrinenko, Andrei V., Zhukovsky, Sergei V.   +2 more
core   +3 more sources

Performance of single wire earth return transformers with amorphous alloy core in a rural electric energy distribution system

Materials Research, 2012
In this paper are presented some considerations about the performance of single wire earth return amorphous alloy core transformers in comparison with conventional silicon steel sheets cores transformers used in rural electric energy distribution network.
Benedito Antonio Luciano, Renato Cucato Inácio, Pablo de Paula e Silva, Francisco das Chagas Fernandes Guerra, Raimundo Carlos Silvério Freire   +4 more
doaj  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Analysis of Effects of Magnetic Slot Wedges on Characteristics of Large Induction Motors

, 2011
Magnetic slot wedges are often used to improve starting performance of large induction motors. In this paper we have investigated – through simulation – the effects of the wedges on the performance characteristics of the motor and core losses under no ...
Dems, M., Komeza, K., Sykulski, J.K.
core  

Core loss reduction in electrical steels through materials processing [PDF]

, 1999
Research has been conducted into the effects of laser scribing on the core losses of soft magnetic materials. Various types of lamination steels for use in electric motors and transformers were studied including iron based alloys containing carbon ...
Jiles, David, Jiles, David, Verbrugge, B.   +2 more
core   +3 more sources

High-Frequency Gap Losses in Nanocrystalline Cores

IEEE Transactions on Power Electronics, 2017
Finite element analysis is used to examine the gap losses that occur in finely laminated nanocrystalline inductor cores under high-frequency operation. The losses are seen to be concentrated in the region of the air gap and the dependence of the losses on key design parameters and operating conditions is explored.
Wang, Yiren, Calderon-Lopez, Gerardo, Forsyth, Andrew   +2 more
openaire   +1 more source

Influence of Niobium as Microalloying Element in 3%Si Steel Grade for Electrical Industry

The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2012
The paper presents the results of the laboratory research on the chemical composition and crystallographic texture in 3% Si steels and their influence on the level of magnetic losses in the final sheet.
Ana DONIGA
doaj  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source