Results 71 to 80 of about 480,920 (265)

Design of Volume Parameters of Large-Particle-Size Asphalt Mixture Based on the Vertical Vibration Compaction Method

open access: yesApplied Sciences
Volume parameters such as the volume of voids (VV), voids filled with asphalt (VFA), and voids in mineral aggregates (VMA) all have significant impact on asphalt mixtures.
Yingjun Jiang   +6 more
doaj   +1 more source

The Investigation of Nonavailability of Passive Safety Systems Effects on Small Break LOCA Sequence in AP1000 Using RELAP5 MOD 4.0

open access: yesScience and Technology of Nuclear Installations, 2016
The passive safety systems of AP1000 are designed to operate automatically at desired set-points. However, the unavailability or failure to operate of any of the passive safety systems will change the accident sequence and may affect reactor safety.
Anwar Hussain, Amjad Nawaz
doaj   +1 more source

A note on two expressions for the spatial power spectrum of the geomagnetic field

open access: yesAnnals of Geophysics, 1996
The spatial power spectrum of the geomagnetic field is usually assumed to be exponential in the spherical harmonic degree (n). An equally valid assumption, however, is that the spectrum at the surface of the Earth's core has a power-law dependence on n ...
D. R. Barraclough, A. De Santis
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Computational Systems Pharmacology, Molecular Docking and Experiments Reveal the Protective Mechanism of Li-Da-Qian Mixture in the Treatment of Glomerulonephritis

open access: yesJournal of Inflammation Research, 2021
Wei Zhou,1,2,* Yugen Sha,2,* Jingxia Zeng,3,* Xiaoyue Zhang,4 Aihua Zhang,1,2 Xuhua Ge1,3 1Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Nephrology,
Zhou W   +5 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

High Sensitive Temperature Sensor Using a Liquid-core Optical Fiber with Small Refractive Index Difference Between Core and Cladding Materials

open access: yesSensors, 2008
An intensive temperature sensor based on a liquid-core optical fiber has been demonstrated for the measuring the temperature of the environment. The core of fiber is filled with a mixture of toluene and chloroform in order to make the refractive index of
Yu Zhu, Xianfeng Chen, Yonghao Xu
doaj  

Home - About - Disclaimer - Privacy