Results 81 to 90 of about 5,396,651 (301)

FASN inactivation-induced progranulin (GRN) expression promotes lysosome-dependent cell death to suppress leukemogenesis

Cell Reports
Summary: Cancer cells rely on lipogenesis in addition to exogenous lipid uptake, and fatty acid synthase (FASN) is aberrantly overexpressed in myeloid leukemia, yet its role in leukemogenesis is unclear. We show that FASN is essential for leukemogenesis.
Meng Su, Qinglin Li, Zhiyi Lv, Xinshu Xie, Yating Lu, Yaohui He, Hanqi Liu, Hui Cao, Jie Ouyang, Qiao Zhang, Xuezhen Ma, Yexin Yang, Ailing Zou, Kang Liu, Shuqian Xu, Ji Li, Lili Chen, Xin Lu, Jie Yang, Caiming Wu, Lu Liu, Lei Zhang, Yue Sheng, Yong Huang, Yang Mei   +24 more
doaj   +1 more source

Inverse problem for the Earth's core evolution model

Russian Journal of Earth Sciences, 2020
The size and the age of the inner core impose constraints in modeling of the Earth's core evolution. The origin of the solid core corresponds to the change in convection regime in the core and, correspondingly, to the change in the magnetic field ...
Reshetnyak M Yu
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Skillful subseasonal ensemble predictions of heat wave onsets through better representation of land surface uncertainties

npj Climate and Atmospheric Science
Uncertainties in land surface processes notably limit subseasonal heat wave (HW) onset predictions. A better representation of the uncertainties in land surface processes using ensemble prediction methods may be an important way to improve HW onset ...
Qiyu Zhang, Mu Mu, Guodong Sun
doaj   +1 more source

LMO7 deficiency reveals the significance of the cuticular plate for hearing function

Nature Communications, 2019
In contrast to the extensively studied mechanosensory hair bundle, the cuticular plate is not as well understood. In this study, authors describe the discovery of a hair cell protein called LIM only protein 7, which is localized in the cuticular plate ...
Ting-Ting Du, James B. Dewey, Elizabeth L. Wagner, Runjia Cui, Jinho Heo, Jeong-Jin Park, Shimon P. Francis, Edward Perez-Reyes, Stacey J. Guillot, Nicholas E. Sherman, Wenhao Xu, John S Oghalai, Bechara Kachar, Jung-Bum Shin   +13 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Tdrd15 is dispensable for male fertility and spermatogenesis in the golden hamster

European Journal of Medical Research
Tudor domain-containing proteins (TDRDs) constitute an evolutionarily conserved protein family and are critical for germline development and piRNA pathway regulation, with established roles in male fertility.
Miao Zhu, Yijian Xiang, Haodong Wang, Shanmeizi Zhao, Wentao Zeng, Jianmin Li, Bing Yao   +6 more
doaj   +1 more source

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

Frontiers in Immunology
With the prevalence of sequentially-emerged sublineages including BA.1, BA.2 and BA.5, SARS-CoV-2 Omicron infection has transformed into a regional epidemic disease.
Wenqi Wang, Wenqi Wang, Qiushi Jin, Qiushi Jin, Ruixue Liu, Ruixue Liu, Wentao Zeng, Pengfei Zhu, Pengfei Zhu, Tingting Li, Tingting Li, Tiecheng Wang, Haiyang Xiang, Hang Zhang, Qin Chen, Yun Gao, Yana Lai, Fang Yan, Xianzhu Xia, Xianzhu Xia, Jianmin Li, Xuefeng Wang, Yuwei Gao, Yuwei Gao   +23 more
doaj   +1 more source

ETNOMATEMATIKA: KRISTALISASI BUDAYA DALAM MODEL PEMBELAJARAN 3R CORE

Barekeng, 2019
The 3R learning model is a learning model that emphasizes Reading, Writing and Arithmatic based on the context of the 21st century skills. The 3R learning model is translated into life and career skills, learning and innovation skills and information ...
Feny Rita Fiantika, D. Darsono, Ika S.
doaj   +1 more source

Cores of Countably Categorical Structures

, 2007
A relational structure is a core, if all its endomorphisms are embeddings. This notion is important for computational complexity classification of constraint satisfaction problems.
Erich Grädel, Manuel Bodirsky
core   +1 more source