Results 61 to 70 of about 619,710 (248)
Australian and New Zealand Journal of Public Health, 2016 Objective: To qualitatively explore how farmers perceive personal risk of an occupational quad‐bike incident and develop a model of the factors that modify this perception. Methods: Grounded theory methods were used to inform data collection and analysis.
Lynne Clay +3 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Open Innovations and Living Labs: Promises or Challenges to Regional Renewal
European Spatial Research and Policy, 2012 The paper brings to the foreground modes and strategies of organising purposeful action that may be conductive to local and regional actors’ successful coping in the more and more competitive environment.
Ilari Karppi
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Community-Based Learning: A Primer
Irish Journal of Academic Practice, 2017 Employers are increasingly demanding graduates with industry-ready communication, leadership, emotional intelligence and social ethics skills. Community-based learning (CBL) is a pedagogical approach which has tremendous potential to produce graduates ...
Geraldine Dowling +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
An algorithm evaluation for discovering classification rules with gene expression programming
International Journal of Computational Intelligence Systems, 2016 In recent years, evolutionary algorithms have been used for classification tasks. However, only a limited number of comparisons exist between classification genetic rule-based systems and gene expression programming rule-based systems.
Alain Guerrero-Enamorado +3 more
doaj +1 more source
Model-driven engineering approach to design and implementation of robot control system [PDF]
, 2013 In this paper we apply a model-driven engineering approach to designing domain-specific solutions for robot control system development. We present a case study of the complete process, including identification of the domain meta-model, graphical notation
Trojanek, Piotr
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Reframing Professionalism: The Virtuous Professional
MedEdPublish, 2018 In response to prevalent unprofessional behaviors during the 1990s, the medical school administration at Michigan State University's College of Human Medicine developed a student curriculum for professional development, called "The Virtuous Student ...
William Wadland +7 more
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