Results 41 to 50 of about 42,772 (260)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

ABAC access control policy generation technique based on deep learning

open access: yesTongxin xuebao, 2020
To solve the problem of automatic generation of access control policies, an access control policy generation framework based on deep learning was proposed.Access control policy based on attributes could be generated from natural language texts.This ...
Aodi LIU, Xuehui DU, Na WANG, Rui QIAO
doaj   +2 more sources

The Task of Detecting Unacceptable Information Security Events in the Information Infrastructure

open access: yesОткрытое образование (Москва)
The purpose of the study is to develop an advanced approach to solving the task of detecting unacceptable events in the field of information security to improve incident detection accuracy and reduce the number of false positives.
Darya A. Evdokimova, Andrey A. Mikryukov
doaj   +1 more source

Serial reduction optimization research of complex product workflow’s accuracy under the time constraint

open access: yesAdvances in Mechanical Engineering, 2016
Model complex production business contains the attributes of completion time, accuracy, and so on; these factors influence each other; and pursuing the balance of these factors is the core idea of the article.
Zhi-yong Luo   +3 more
doaj   +1 more source

Where do graduates Develop their Enterprise Skills? The Value of the Contribution of Higher Education Institutions’ Context

open access: yes, 2015
This study investigates the value of the contribution of HEIs’ context in developing graduates enterprise skills. HEIs are under pressure to develop more enterprising graduates, particularly with the increasing numbers of graduates seeking employment and
Refai, Deema   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Developing a hierarchical cognitive second language (L2) reading model using multi-dimensional fuzzy Delphi method and interpretive structural modeling

open access: yesActa Psychologica
Many secondary students learn to read academic texts in a non-native language. However, classroom guidance and diagnostic tests often rely on flat skills lists that ignore prerequisite relations among reading processes.
Muhamad Firdaus Mohd Noh   +2 more
doaj   +1 more source

Rationalization of the parameters of the cylindrical bridge support (theoretical basis)

open access: yesMATEC Web of Conferences, 2018
Paper deals with a new constructive solution of a massive concrete pillar intended, mostly, for construction of railway and road bridge supports and with procedure of rationalization of its parameters.
Shmukler Valery   +2 more
doaj   +1 more source

Important non-academic attributes in Australian initial teacher education

open access: yes, 2021
Current policy initiatives are requiring Initial Teacher Education (ITE) providers to select teachers with both the academic and non-academic attributes that ensure their suitability for teaching and their classroom readiness.
Bianca Coleman (14734045)   +2 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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