Results 41 to 50 of about 619,710 (248)

AI-Driven Semantic Framework for Automated Construction Planning and Scheduling with BIM and Digital Twin Integration

open access: yesEngineering Proceedings
Construction planning and scheduling, including task sequences, constraints, and interdependencies, is poorly structured within digital models such as BIM and Digital Twin and lacks effective integration with planning documents to support scheduling ...
Qais Amarkhil   +2 more
doaj   +1 more source

Surface soil metal elements variability affected by environmental and soil properties.

open access: yesPLoS ONE, 2021
Identifying the factors controlling the spatial variability of soil metal elements could be a challenge task due to the interaction of environmental attributes and human activities.
Wei Wu   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Serial reduction optimization research of complex product workflow’s accuracy under the time constraint

open access: yesAdvances in Mechanical Engineering, 2016
Model complex production business contains the attributes of completion time, accuracy, and so on; these factors influence each other; and pursuing the balance of these factors is the core idea of the article.
Zhi-yong Luo   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

A Survey of Requirements Engineering Methods for Pervasive Services [PDF]

open access: yes, 2006
Designing and deploying ubiquitous computing systems, such as those delivering large-scale mobile services, still requires large-scale investments in both development effort as well as infrastructure costs. Therefore, in order to develop the right system,
Eck, P., Kolos-Mazuryk, L., Wieringa, R.
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Development of a tool for quality control audits in hospital enteral nutrition

open access: yesNutrición Hospitalaria, 2014
Background and aims: Malnutrition is very prevalent in hospitals, causing physical capacity deterioration, increasing complications and raising mortality. This scenario overloads public health costs enormously.
Guilherme Duprat Ceniccola   +2 more
doaj   +1 more source

Exploiting the Nature of Repetitive Actions for Their Effective and Efficient Recognition

open access: yesFrontiers in Computer Science, 2022
In the field of human action recognition (HAR), the recognition of actions with large duration is hindered by the memorization capacity limitations of the standard probabilistic and recurrent neural network (R-NN) approaches that are used for temporal ...
Konstantinos Bacharidis   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

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