Results 161 to 170 of about 2,734 (188)

Livogrit mitigates ANIT-induced cholestasis-like symptoms in an in vivo model by curbing hepatic inflammation and regulating BAX, TGF-β, MMP-9 and α-SMA gene expression. [PDF]

Heliyon
Balkrishna A, Paliwal R, Singh S, Singh R, Gohel V, Dev R, Bhattacharya K, Sinha S, Varshney A.   +8 more
europepmc   +1 more source

Bioactive small compounds effectively inhibit ChREBP overexpression to treat NAFLD and T2DM: A computational drug development approach. [PDF]

Heliyon
Devnath HS, Medha MM, Islam MN, Biswas P, Oisay DS, Hossain A, Ema RS, Tareq MMI, Golder M, Hasan MN, Biswas B, Sadhu SK.   +11 more
europepmc   +1 more source

Toxicological Evaluation of a Polyherbal Formulation (18KHT01) and Validation of UPLC-DAD Method for Quality Control. [PDF]

Biomed Res Int
Pandeya PR, Lamichhane R, Lamichhane G, Lee KH, Jung HJ.   +4 more
europepmc   +1 more source

Corilagin relieves atherosclerosis via the toll-like receptor 4 signaling pathway in vascular smooth muscle cells. [PDF]

Int J Immunopathol Pharmacol
Wang Y, Li Y, Chen Y, Mao J, Ji J, Zhang S, Liu P, Pronyuk K, Fisher D, Dang Y, Zhao L.   +10 more
europepmc   +1 more source

Role of Nrf2/HO-1 pathway on inhibiting activation of ChTLR15/ChNLRP3 inflammatory pathway stimulated by E. tenella sporozoites. [PDF]

Poult Sci
Bai B, Liu Q, Kong R, Jia Z, Chen H, Zhi W, Wang B, Ma C, Ma D.   +8 more
europepmc   +1 more source

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Agent in Urgent Need of Clinical Practice: Corilagin

Mini-Reviews in Medicinal Chemistry, 2023
Abstract: Corilagin is a naturally occurring water-soluble retrogallic acid tannin, which can be extracted from many kinds of plants. Known at present, it is the main effective ingredient of Phyllanthus urinaria L., Geranium wilfordii Maxim., Phyllanthus matsumurae Hayata, and Trifolium repens L.
XueJia Wang, David Fisher, Khrystyna Pronyuk, Yiping Dang, Lei Zhao   +4 more
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Corilagin attenuates osteoclastic osteolysis by enhancing HO‐1 and inhibiting ROS

Journal of Biochemical and Molecular Toxicology, 2022
AbstractChinese herbal medicine has well‐established therapeutic effects in various diseases. Corilagin (Cor), a gallic acid tannin in Phyllanthus niruri L., has anti‐inflammatory and antioxidant effects in many diseases. However, its role in osteoclast‐related bone diseases has not been determined.
Shaolin Tan, Yuangang Su, Linke Huang, Siyu Deng, Guohua Yan, Xue Yang, Runfeng Chen, Yansi Xian, Jiamin Liang, Qian Liu, Jianwen Cheng   +10 more
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Total Synthesis of (−)-Corilagin

Journal of the American Chemical Society, 2008
The synthesis of corilagin was achieved by the integration of the development of the oxidative coupling of the symmetrically protected gallates and the temporarily ring-opened synthetic route for the 3,6-hexahydroxydiphenoyl (HHDP) bridge. This is the first total synthesis of the 1C4/B-ellagitannins, which contain ring-flipped glucose.
Hidetoshi, Yamada, Kohei, Nagao, Kazutoyo, Dokei, Yusuke, Kasai, Naoki, Michihata   +4 more
openaire   +2 more sources

Antihypertensive effect of corilagin in the rat

Canadian Journal of Physiology and Pharmacology, 1995
The antihypertensive effect of corilagin, one of the ellagitannins purified from the seeds of Euphoria longana Lam. (Sapindaceae), was investigated in the spontaneously hypertensive rat (SHR). Administration of corilagin into conscious SHR at 5 mg/kg produced an antihypertensive effect equivalent to that induced by 1 mg/kg of guanethidine.
J T, Cheng, T C, Lin, F L, Hsu
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