Acute oral toxicity of the ellagitannin geraniin and a geraniin-enriched extract from Nephelium lappaceum L rind in Sprague Dawley rats [PDF]
Heliyon, 2019 Despite the lack of its toxicity evaluation, traditional herbal products are being widely used for various health indications. Geraniin, an ellagitannin, is a bioactive compound found in many traditional herbal medicines. In spite its numerous health benefits ranging from anti-inflammatory, anti-hyperglycaemic, hepatoprotective, anti-cancer and anti ...
Mohanambal Moorthy, Uma Devi Palanisamy
exaly +4 more sources
The physicochemical properties of geraniin, a potential antihyperglycemic agent
Pharmaceutical Biology, 2015 Natural products play a vital role in the discovery of leads for novel pharmacologically active drugs. Geraniin (GE) was identified as the major compound in the rind of Nephelium lappaceum L. (Sapindaceae), while ellagic and gallic acids have been shown to be its main metabolites. GE and its metabolites possess a range of bioactive properties including
Uma Devi Palanisamy
exaly +3 more sources
Ferroptosis‐Inhibitory Effect and Possible Mechanisms of Ellagitannin Geraniin
ChemistryOpen, 2021 AbstractThe search for safe and effective ferroptosis‐inhibitors has become an important topic. Geraniin, an ellagitannin bearing hexahydroxydiphenoyl (HHDP) and dehydrohexahydroxydiphenoyl (DHHDP) groups, was observed to inhibit erastin‐induced ferroptosis in bone marrow‐derived mesenchymal stem cells (bmMSCs). To determine the mechanism, geraniin was
Dr. Ban Chen +6 more
openaire +5 more sources
Antioxidants, 2022 Geraniin, an ellagitannin, has ameliorative properties against high-fat diet (HFD)-induced metabolic syndrome. Since geraniin has poor bioavailability, we hypothesised the interaction of this compound with gut microbiota as the main mechanism for improving metabolic aberrations.
Mohanambal Moorthy +3 more
openaire +3 more sources
Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication [PDF]
, 2017 Background: The rapid rise and spread in dengue cases, together with the unavailability of safe vaccines and effective antiviral drugs, warrant the need to discover and develop novel anti-dengue treatments.
Chew, Miaw Fang * +5 more
core +1 more source
Antihypertensive Action of Geraniin in Rats
Journal of Pharmacy and Pharmacology, 1994 AbstractThe effects of geraniin, one of the ellagitannins purified from the leaves of Sapium sebiferum, on blood pressure were investigated in the spontaneously hypertensive rat (SHR). A single intravenous bolus injection of geraniin into anaesthetized SHRs lowered the arterial mean blood pressure in a dose-dependent manner without affecting the heart ...
J T, Cheng, S S, Chang, F L, Hsu
openaire +2 more sources
Identification of Hydrolyzable Tannins (Punicalagin, Punicalin and Geraniin) as Novel inhibitors of Hepatitis B Virus Covalently Closed Circular DNA [PDF]
, 2016 The development of new agents to target HBV cccDNA is urgently needed because of the limitations of current available drugs for treatment of hepatitis B.
Cai, Dawei +6 more
core +1 more source
Metabolites of the Ellagitannin Geraniin and Their Antioxidant Activities [PDF]
Planta Medica, 2011 Different types of ellagitannins are reported to have various biological activities, such as antioxidant, antiviral, and antitumor activities. However, there are few definitive studies on the absorption and metabolism of ellagitannins. This review compares the absorption and metabolism of ellagitannins, and the antioxidant properties of their ...
openaire +2 more sources
Bio-guided fractionation of extracts of Geranium robertianum L.: Relationship between phenolic profile and biological activity [PDF]
, 2017 Geranium robertianum L. is used in folk medicine and herbalism practice for the treatment of a variety of ailments. Recently, we studied the bioactivity of several aqueous and organic extracts of this plant.
Barros, Lillian +6 more
core +1 more source
Polyphenolic content, in vitro antioxidant activity and chemical composition of extract from Nephelium lappaceum L. (Mexican rambutan) husk [PDF]
, 2017 Objective: To determinate the recovery of total polyphenolic compounds content, in vitro antioxidant activity and HPLC/ESI/MS characterization of extract from Nephelium lappaceum L. (Mexican rambutan).
Aguilar González, Cristóbal Noé +7 more
core +1 more source