Geraniin is the major compound in Nephelium lappaceum peel and exhibits significant immunomodulatory effects. So, this study aimed to evaluate the anti-inflammatory effects of Nephelium lappaceum peel extract and geraniin through in vitro experiments and
Eun-Jeong Lee +7 more
doaj +2 more sources
The Geraniin-Rich Extract from Reunion Island Endemic Medicinal Plant Phyllanthus phillyreifolius Inhibits Zika and Dengue Virus Infection at Non-Toxic Effect Doses in Zebrafish [PDF]
The mosquito-borne viruses dengue (DENV) and Zika (ZIKV) viruses are two medically important pathogens in tropical and subtropical regions of the world. There is an urgent need of therapeutics against DENV and ZIKV, and medicinal plants are considered as
Juliano G. Haddad +8 more
doaj +2 more sources
Geraniin Alleviates High-Fat Diet-Induced Atherosclerosis in <i>ApoE</i> <sup>-/-</sup> Mice. [PDF]
GE treatment significantly reduced serum concentrations of lipids, oxidative stress damage, lipid deposition, and atherosclerotic plaque lesions in the ApoE−/− mice. A network pharmacology analysis indicated that the beneficial effect of GE treatment on atherosclerosis is closely related to its effect on oxidative stress, cell apoptosis, and ...
Xie Y +7 more
europepmc +2 more sources
Geraniin Ameliorates Hypertensive Vascular Remodelling in a Diet-Induced Obese Animal Model through Antioxidant and Anti-Inflammatory Effects. [PDF]
Geraniin, an ellagitannin, has shown a potent blood pressure-lowering effect in vivo. Therefore, this study aims to further characterize the ability of geraniin to attenuate hypertensive vascular dysfunction, a key feature of cardiovascular disease (CVD)
Goh BH +5 more
europepmc +2 more sources
Ferroptosis‐Inhibitory Effect and Possible Mechanisms of Ellagitannin Geraniin
The search for safe and effective ferroptosis‐inhibitors has become an important topic. Geraniin, an ellagitannin bearing hexahydroxydiphenoyl (HHDP) and dehydrohexahydroxydiphenoyl (DHHDP) groups, was observed to inhibit erastin‐induced ferroptosis in ...
Dr. Ban Chen +6 more
doaj +1 more source
Geraniin inhibits bladder cancer cell growth via regulation of PI3K/AKT signaling pathways [PDF]
Purpose: The effect of geraniin on human bladder transitional carcinoma was not clear, this study was thus intended to reveal it and reveal the mechanism.
Xu, Junwei +4 more
core +1 more source
Residues ASN94 and GLN41 presented the highest frequency in molecular docking tests. The geraniin-glycoprotein D(gD) complexes was stable with RMSD(root mean square deviation)value less than 0.3 nm.
Liang Cheng (228343) +2 more
core +1 more source
Rambutan (Nephelium lappaceum L.) is a tropical fruit from Asia which has become the main target of many studies involving polyphenolic analysis. Mexico produces over 8 million tons per year of rambutan, generating a huge amount of agro-industrial waste ...
Luis Estrada-Gil +7 more
doaj +1 more source
Amariin is an ellagitannin with two dehydrohexahydroxydiphenoyl (DHHDP) moieties connecting glucose 2,4- and 3,6-hydroxy groups. This tannin is predominant in the young leaves of Triadica sebifera and Carpinus japonica. However, as the leaves grow, the 3,
Manami Era +3 more
doaj +1 more source
Geraniin Alleviates Mouse Laser-Induced Choroidal Neovascularisation by Inhibiting Choroidal Endothelial Cell ACE2/Ang-(1-7)/MasR/IL-10 Pathway. [PDF]
ABSTRACT Anti‐vascular endothelial growth factor (VEGF) drugs suppress choroidal neovascularisation (CNV), thus improving vision. However, some patients may have a poor response or develop resistance to anti‐VEGF drugs. Geraniin (GE), a polyphenol isolated from an herb called Phyllanthus amarus, possesses anti‐angiogenic properties. This study aimed to
Lu H +7 more
europepmc +2 more sources

