Geraniin ameliorate experimental acute reflux esophagitis via NF-κB regulated anti-inflammatory activities in rats [PDF]
Applied Biological Chemistry, 2019 Repeated reflux of gastric acid and stomach contents into the esophagus leads to esophagus damage, including inflammation, ulcer, and hemorrhage in the epithelium.
Hyeon Hwa Nam +3 more
doaj +2 more sources
The physicochemical properties of geraniin, a potential antihyperglycemic agent
Pharmaceutical Biology, 2015 Natural products play a vital role in the discovery of leads for novel pharmacologically active drugs. Geraniin (GE) was identified as the major compound in the rind of Nephelium lappaceum L. (Sapindaceae), while ellagic and gallic acids have been shown to be its main metabolites. GE and its metabolites possess a range of bioactive properties including
Uma Devi Palanisamy
exaly +3 more sources
The Geraniin-Rich Extract from Reunion Island Endemic Medicinal Plant Phyllanthus phillyreifolius Inhibits Zika and Dengue Virus Infection at Non-Toxic Effect Doses in Zebrafish [PDF]
Molecules, 2020 The mosquito-borne viruses dengue (DENV) and Zika (ZIKV) viruses are two medically important pathogens in tropical and subtropical regions of the world. There is an urgent need of therapeutics against DENV and ZIKV, and medicinal plants are considered as
Juliano G. Haddad +8 more
doaj +2 more sources
Assessment of Wound-Healing Properties of Medicinal Plants: The Case of Phyllanthus muellerianus [PDF]
Frontiers in Pharmacology, 2018 Phyllanthus muellerianus (Family Euphorbiaceae) is a shrub, which is widely distributed in West Africa and employed traditionally as a wound-healing agent especially in Ghana.
Yaw D. Boakye +5 more
doaj +2 more sources
Free Radical Scavenging and Alpha/Beta-glucosidases Inhibitory Activities of Rambutan (Nephelium lappaceum L.) Peel Extract [PDF]
Indonesian Biomedical Journal, 2015 BACKGROUND: Diabetes mellitus (DM) is associated with oxidative reaction and hyperglycemic condition. Human body has an antioxidant defense system toward free radical, but overproduction of free radical causing imbalance condition between the free ...
Wahyu Widowati +4 more
doaj +3 more sources
Influence of fecal fermentation on the anthelmintic activity of proanthocyanidins and ellagitannins against human intestinal nematodes and Caenorhabditis elegans [PDF]
Frontiers in PharmacologySome tannin-rich plants such as Combretum mucronatum and Phyllanthus urinaria are widely used in Africa for the control of parasitic nematodes in both humans and livestock.
Jonathan Jato +12 more
doaj +2 more sources
Anti-oxidant, anti-apoptotic and anti-inflammatory effects of geraniin in spinal cord injury in rats: role of COX-2 [PDF]
Folia MorphologicaBACKGROUND: Spinal cord injury (SCI) has a devastating effect on degeneration of the spinal column, and vascular problems. However, the currently available therapeutic interventions are insufficient to address these effects, which lead to significant ...
Yaping Wang +3 more
doaj +3 more sources
Geraniin Alleviates High-Fat Diet-Induced Atherosclerosis in <i>ApoE</i> <sup>-/-</sup> Mice. [PDF]
Food Sci NutrGE treatment significantly reduced serum concentrations of lipids, oxidative stress damage, lipid deposition, and atherosclerotic plaque lesions in the ApoE−/− mice. A network pharmacology analysis indicated that the beneficial effect of GE treatment on atherosclerosis is closely related to its effect on oxidative stress, cell apoptosis, and ...
Xie Y +7 more
europepmc +2 more sources
Geraniin Ameliorates Hypertensive Vascular Remodelling in a Diet-Induced Obese Animal Model through Antioxidant and Anti-Inflammatory Effects. [PDF]
Nutrients, 2023 Geraniin, an ellagitannin, has shown a potent blood pressure-lowering effect in vivo. Therefore, this study aims to further characterize the ability of geraniin to attenuate hypertensive vascular dysfunction, a key feature of cardiovascular disease (CVD)
Goh BH +5 more
europepmc +3 more sources
In vitro and silico studies of geraniin interfering with HSV-2 replication by targeting glycoprotein D [PDF]
, 2023 Residues ASN94 and GLN41 presented the highest frequency in molecular docking tests. The geraniin-glycoprotein D(gD) complexes was stable with RMSD(root mean square deviation)value less than 0.3 nm.
Liang Cheng (228343) +2 more
core +1 more source