Results 11 to 20 of about 797 (162)

Ferroptosis‐Inhibitory Effect and Possible Mechanisms of Ellagitannin Geraniin

ChemistryOpen, 2021
The search for safe and effective ferroptosis‐inhibitors has become an important topic. Geraniin, an ellagitannin bearing hexahydroxydiphenoyl (HHDP) and dehydrohexahydroxydiphenoyl (DHHDP) groups, was observed to inhibit erastin‐induced ferroptosis in ...
Dr. Ban Chen, Prof. Xican Li, Dr. Jie Liu, Yuling Li, Wanjian Dai, Yingci Chen, Prof. Dongfeng Chen   +6 more
doaj   +5 more sources

Identification of the plant compound geraniin as a novel Hsp90 inhibitor. [PDF]

PLoS ONE, 2013
Besides its function in normal cellular growth, the molecular chaperone heat shock protein 90 (Hsp90) binds to a large number of client proteins required for promoting cancer cell growth and/or survival.
Antonio Vassallo, Maria Carmela Vaccaro, Nunziatina De Tommasi, Fabrizio Dal Piaz, Antonella Leone   +4 more
doaj   +5 more sources

A novel effect of geraniin on OPG/RANKL signaling in osteoblasts [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2018
In this study, the effects of geraniin on osteoprotegerin/receptor activator of nuclear factor-κB ligand(OPG/RANKL) in regulating the proliferation of osteoblasts and suppression of osteoclast-like cells (OLC) in OLC-osteoblast co-cultured system in ...
Xiaochao Zhang, Renhua Yang, Jiang Long, Bo He, Yue Zhang, Ting Fu, Zhiqiang Shen, Peng Chen   +7 more
doaj   +3 more sources

Geraniin Alleviates High-Fat Diet-Induced Atherosclerosis in <i>ApoE</i> ^-/- Mice. [PDF]

Food Sci Nutr
GE treatment significantly reduced serum concentrations of lipids, oxidative stress damage, lipid deposition, and atherosclerotic plaque lesions in the ApoE−/− mice. A network pharmacology analysis indicated that the beneficial effect of GE treatment on atherosclerosis is closely related to its effect on oxidative stress, cell apoptosis, and ...
Xie Y, Liu S, Wei Z, Yu L, Yu J, Xu L, Jiang H, Gu Z.   +7 more
europepmc   +2 more sources

Mass Spectrometry-Based Applications in Tannin Analytics: From Qualitative and Quantitative Analyses to Biological Activity. [PDF]

Mass Spectrom Rev
ABSTRACT Tannins are widespread specialized plant metabolites that contribute significantly to the polyphenol content of plant‐based diets. Their effects on human and animal health vary depending on their structure, with potential benefits including antioxidative, antimicrobial, anthelmintic, and anticarcinogenic properties.
Engström MT, Karonen M.
europepmc   +2 more sources

Geraniin Alleviates Mouse Laser-Induced Choroidal Neovascularisation by Inhibiting Choroidal Endothelial Cell ACE2/Ang-(1-7)/MasR/IL-10 Pathway. [PDF]

J Cell Mol Med
ABSTRACT Anti‐vascular endothelial growth factor (VEGF) drugs suppress choroidal neovascularisation (CNV), thus improving vision. However, some patients may have a poor response or develop resistance to anti‐VEGF drugs. Geraniin (GE), a polyphenol isolated from an herb called Phyllanthus amarus, possesses anti‐angiogenic properties. This study aimed to
Lu H, Cai Q, Li L, Gu J, Zhang Y, Sun H, Su H, Song L.   +7 more
europepmc   +2 more sources

PEG-b-PLGA Nanoparticles Loaded with Geraniin from Phyllanthus Watsonii Extract as a Phytochemical Delivery Model

Applied Sciences, 2020
The study outlined a standardized double emulsion method for simple poly(ethylene glycol)-block-poly(lactic-co-glycolic acid) (PEG-b-PLGA) nanoparticle (NP) synthesis.
Kogilavanee Devasvaran, Sreegayathri Jairaman, Nur Azirah Yahaya, Indu Bala S. Jaganath, Yit Lung Khung, Vuanghao Lim, Siti Hawa Ngalim   +6 more
doaj   +1 more source

Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication

Virology Journal, 2017
Background The rapid rise and spread in dengue cases, together with the unavailability of safe vaccines and effective antiviral drugs, warrant the need to discover and develop novel anti-dengue treatments. In this study the antiviral activity of geraniin,
Siti Aisyah Abdul Ahmad, Uma D. Palanisamy, Bimo A. Tejo, Miaw Fang Chew, Hong Wai Tham, Sharifah Syed Hassan   +5 more
doaj   +1 more source

Recovery of Bioactive Ellagitannins by Ultrasound/Microwave-Assisted Extraction from Mexican Rambutan Peel (Nephelium lappaceum L.)

Molecules, 2022
Rambutan (Nephelium lappaceum L.) is a tropical fruit from Asia which has become the main target of many studies involving polyphenolic analysis. Mexico produces over 8 million tons per year of rambutan, generating a huge amount of agro-industrial waste ...
Luis Estrada-Gil, Juan C. Contreras-Esquivel, Carolina Flores-Gallegos, Alejandro Zugasti-Cruz, Mayela Govea-Salas, Marco A. Mata-Gómez, Raúl Rodríguez-Herrera, Juan A. Ascacio-Valdés   +7 more
doaj   +1 more source

In Vitro, In Vivo, and Clinical Trial Approaches to Investigate the Effects of Medicinal Plants on Burn Wound Healing: A Systematic Review. [PDF]

Int Wound J
ABSTRACT Use of synthetic drugs for the treatment of burn wounds has decreased due to adverse effects, and they are gradually being replaced by compounds obtained from natural products, especially medicinal plants. This review focused on pre‐clinical and clinical studies examining the efficacy of medicinal plants in promoting burn wound healing.
Bagheri M, Zarei SM, Soodmand M, Mardani Nafchi H, Hashemi Poor MH.   +4 more
europepmc   +2 more sources