A novel effect of geraniin on OPG/RANKL signaling in osteoblasts [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2018 In this study, the effects of geraniin on osteoprotegerin/receptor activator of nuclear factor-κB ligand(OPG/RANKL) in regulating the proliferation of osteoblasts and suppression of osteoclast-like cells (OLC) in OLC-osteoblast co-cultured system in ...
Xiaochao Zhang +7 more
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Elaeocarpus sylvestris var. ellipticus Extract and Its Major Component, Geraniin, Inhibit Herpes Simplex Virus-1 Replication [PDF]
PlantsElaeocarpus sylvestris var. ellipticus (ES), which our research group had confirmed inhibits influenza A and SARS-CoV-2 viruses, was investigated to identify new potent and selective inhibitors of herpes simplex virus-1 (HSV–1) replication.
Yeong-Geun Lee +4 more
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Antihypertensive Action of Geraniin in Rats [PDF]
Journal of Pharmacy and Pharmacology, 1994 AbstractThe effects of geraniin, one of the ellagitannins purified from the leaves of Sapium sebiferum, on blood pressure were investigated in the spontaneously hypertensive rat (SHR). A single intravenous bolus injection of geraniin into anaesthetized SHRs lowered the arterial mean blood pressure in a dose-dependent manner without affecting the heart ...
J T, Cheng, S S, Chang, F L, Hsu
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PEG-b-PLGA Nanoparticles Loaded with Geraniin from Phyllanthus Watsonii Extract as a Phytochemical Delivery Model [PDF]
Applied Sciences, 2020 The study outlined a standardized double emulsion method for simple poly(ethylene glycol)-block-poly(lactic-co-glycolic acid) (PEG-b-PLGA) nanoparticle (NP) synthesis.
Kogilavanee Devasvaran +6 more
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Geraniin supplementation increases human keratinocyte proliferation in serum-free culture [PDF]
Universa Medicina, 2015 BACKGROUND Various products used in cellular therapy utilize tissue culture techniques requiring keratinocyte culture. An efficient and clinically acceptable keratinocyte culture system requires supplements with mitogenic activity.
Indra Kusuma, Restu Syamsul Hadi
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Efficacy of geraniin on dengue virus type-2 infected BALB/c mice [PDF]
Virology Journal, 2019 Background Dengue continues to be a major international public health concern. Despite that, there is no clinically approved antiviral for treatment of dengue virus (DENV) infections. In this study, geraniin extracted from the rind of Nephelium lappaceum
Siti Aisyah Abdul Ahmad +4 more
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Geraniin as a potential inhibitor of SARS-CoV-2 3CLpro [PDF]
Natural Product Research, 2022 Geraniin is a polyphenolic compound first isolated from Geranium thunbergii. The major protease (Mpro), namely 3 C-like protease (3CLpro), of coronaviruses is considered an attractive drug target as it is essential for the processing and maturation of viral polyproteins.
Wen-Di, Yu +4 more
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Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication [PDF]
Virology Journal, 2017 Background The rapid rise and spread in dengue cases, together with the unavailability of safe vaccines and effective antiviral drugs, warrant the need to discover and develop novel anti-dengue treatments. In this study the antiviral activity of geraniin,
Siti Aisyah Abdul Ahmad +5 more
doaj +3 more sources
Geraniin supplementation increases human keratinocyte proliferation in serum-free culture [PDF]
Universa Medicina, 2013 Background Various products used in cellular therapy utilize tissue culture techniques requiring keratinocyte culture. An efficient and clinically acceptable keratinocyte culture system requires supplements with mitogenic activity.
Indra Kusuma, Restu Syamsul Hadi
doaj +2 more sources
Geraniin Protects High-Fat Diet-Induced Oxidative Stress in Sprague Dawley Rats [PDF]
Frontiers in Nutrition, 2018 Geraniin, a hydrolysable polyphenol derived from Nephelium lappaceum L. fruit rind, has been shown to possess significant antioxidant activity in vitro and recently been recognized for its therapeutic potential in metabolic syndrome.
Alexis Panny Y. S. Chung +4 more
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