Results 31 to 40 of about 4,167 (263)

Numerical investigation of spreading phenomena of molten corium using EISPH method

Nuclear Engineering and Technology
Understanding the behavior of molten corium is crucial for effective heat management and ensuring the integrity of reactor containment during severe nuclear incidents.
Hee Sang Yoo, Eung Soo Kim
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The main structural-phase states of interaction between model corium of a nuclear reactor and a sacrificial material based on Al2O3 and a lead layer

International Journal of Advanced Nuclear Reactor Design and Technology
This article presents the results of post-experimental studies of the interaction of model light water reactor corium with a candidate sacrificial material (SM) based on Al2O3 (corundum) and a lead layer.
M.K. Skakov, V.V. Baklanov, I.M. Kukushkin, M.K. Bekmuldin, A.S. Akaev, M.N. Azbergenov, A.V. Gradoboev   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Development of ex-vessel corium coolability analysis program(COCCA) with simplified models validated against FARO experiments

Nuclear Engineering and Technology
Molten corium may be discharged into the reactor cavity if the Reactor Pressure Vessel (RPV) fails during a severe accident. The cooling and stabilization of the discharged molten corium in the reactor cavity are crucial for preventing further accident ...
Jaehoon Jung, Seokgyu Jeong
doaj   +1 more source

A contribution to the morphology and ecology of Mycenastrum corium (Agaricales)

Acta Mycologica, 2013
An interesting collection of Mycenastrum corium from Suwałki Region (NE Poland) close to the Russian and Lithuenian frontiers is presented in this paper. Two specimens were found ca. 20 cm under the soil surface.
Maria Ławrynowicz, Andrzej Radwański
doaj   +1 more source

Numerical Study on the Corium Pool Heat Transfer With OpenFOAM

Frontiers in Energy Research, 2020
In order to ensure the successful implementation of in-vessel retention strategy to terminate molten corium pool evolution, it is necessary to evaluate the heat flux distribution on the lower head wall of reactor pressure vessel.
Zhiguo Xi, Yuwen Hu, Houjun Gong, Luteng Zhang, Luteng Zhang, Zaiyong Ma, Wan Sun, Shanshan Bu, Shanshan Bu, Liangming Pan   +9 more
doaj   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source