Results 31 to 40 of about 4,161 (262)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

The main structural-phase states of interaction between model corium of a nuclear reactor and a sacrificial material based on Al2O3 and a lead layer

International Journal of Advanced Nuclear Reactor Design and Technology
This article presents the results of post-experimental studies of the interaction of model light water reactor corium with a candidate sacrificial material (SM) based on Al2O3 (corundum) and a lead layer.
M.K. Skakov, V.V. Baklanov, I.M. Kukushkin, M.K. Bekmuldin, A.S. Akaev, M.N. Azbergenov, A.V. Gradoboev   +6 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Numerical simulation on heat transfer in RPV lower head corium pools

He jishu, 2022
BackgroundIn-vessel Retention (IVR) refers to the prevention of pressure vessel melt-through failure by injecting cooling water into the gap between the pressure vessel and the heat insulation layer during a serious accident in a nuclear power plant ...
ZHU Guangyu, MIN Jinkun, JING Jianping, WANG Kunpeng, LIU Fudong   +4 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

A contribution to the morphology and ecology of Mycenastrum corium (Agaricales)

Acta Mycologica, 2013
An interesting collection of Mycenastrum corium from Suwałki Region (NE Poland) close to the Russian and Lithuenian frontiers is presented in this paper. Two specimens were found ca. 20 cm under the soil surface.
Maria Ławrynowicz, Andrzej Radwański
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Development of ex-vessel corium coolability analysis program(COCCA) with simplified models validated against FARO experiments

Nuclear Engineering and Technology
Molten corium may be discharged into the reactor cavity if the Reactor Pressure Vessel (RPV) fails during a severe accident. The cooling and stabilization of the discharged molten corium in the reactor cavity are crucial for preventing further accident ...
Jaehoon Jung, Seokgyu Jeong
doaj   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source