Results 91 to 100 of about 233,538 (301)

Understanding Keratoconus in Down Syndrome: From Etiology to Management – A Narrative Review

Clinical Ophthalmology
Venugopal Anitha,1 Nambi Nallasamy,2 Josephine S Christy,3 Olav Kristianslund,4 Kirk AJ Stephenson,5 Hassan Hashemi,6 Revathi Rajaraman,7 Soheila Asgari8 1Department of Cornea & Refractive Services, Aravind Eye Hospital and Postgraduate Institute of ...
Anitha V, Nallasamy N, Christy JS, Kristianslund O, Stephenson KAJ, Hashemi H, Rajaraman R, Asgari S   +7 more
doaj  

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Soft and Adhesive Cardiac Patch for Electrophysiological and Contraction Measurement

Advanced Science, EarlyView.
This study developed an epicardial electronic patch with a modulus similar to that of the heart (approximately 65kPa), which can collect stable electrocardiogram signals and myocardial contractility on the surface of a dynamically beating heart. This is attributed to the hydrogen bond interaction formed between the amino and catechol groups in the ...
Wuliang Chen, Xinyu Shen, Hanning Liu, Lamei Du, Caicai Jiao, Longfei Li, Qian Wang, Qiuting Zhang, Lixue Tang, Liang Hu, Yubo Fan   +10 more
wiley   +1 more source

Enzymatic Encoding of Topology in an Intrinsically Disordered Single‐Chain Protein

Angewandte Chemie, EarlyView.
Enzymatic intramolecular cross‐linking enables topology control in intrinsically disordered proteins, yielding SCNPs with reproducible cavity architectures. Using β‐casein and microbial transglutaminase, sparse, sequence‐resolved constraints drive compact collapse without inducing secondary structure.
Joshua Johani, Kristin Eichelberger, Olga Guskova, Simbulele Charlotte Dunjwa, Hans Bolinsson, Anna‐Maria Börjesdotter, Lars Nilsson, Doris Jaros, Harald Rohm, Albena Lederer   +9 more
wiley   +2 more sources

Clinical and microbiological profile of patients with fungal keratitis demonstrating unusual yeast-like structures in potassium hydroxide with calcofluor white preparation of corneal scraping

Journal of Ophthalmic Inflammation and Infection
Background To report a case series of microbial keratitis showing atypical yeast-like structures in direct microscopy which were culture-negative but subsequently identified as yeast cells by PCR and DNA sequencing. Main text This is a retrospective, non-
Sikha Misra, Savitri Sharma, Manas Ranjan Barik, Nisha Rani, Sujata Das, Srikant Kumar Sahu, Smruti Rekha Priyadarshini, Himansu Sekhar Behera   +7 more
doaj   +1 more source

Keratorefractive lenticule extraction (KLEx) versus femtosecond laser-assisted in situ keratomileusis (FS-LASIK) for the treatment of myopia and compound myopic astigmatism: study protocol of a randomised clinical trial in Mexico

BMJ Open
Introduction Kerato-lenticule extraction (KLEx) is a refractive surgery technique that, in contrast with femtosecond laser-assisted in situ keratomileusis (FS-LASIK), does not require the creation of a flap to correct refractive defects.
Alejandro Navas, Arturo Ramirez-Miranda, Nicolás Kahuam-López, Mauricio Muleiro-Alvarez, Guillermo Raul Vera-Duarte, Eber A. Medina-Estrada, Gustavo Ortiz-Morales, Enrique L. Graue-Wiechers, Enrique O. Graue-Hernandez   +8 more
doaj   +1 more source

REGENERATION OF THE CORNEA [PDF]

Journal of the American Medical Association, 1909
It has long been known that the epithelium of the cornea would regenerate itself after being destroyed intentionally or by accident. Haller 1 as early as 1763, in his "Elementary Physiology of the Human Body," asserts that regeneration of the cornea takes place, and even the oldest ophthalmologists 2 assume that regeneration of corneal tissue occurs ...
openaire   +2 more sources

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Development of ex vivo organ culture models to mimic human corneal scarring [PDF]

, 2012
PURPOSE: To develop ex vivo organ culture models of human corneal scarring suitable for pharmacological testing and the study of the molecular mechanisms leading to corneal haze after laser surgery or wounding.
Damour, O, Galiacy, SD, Hulmes, DJ, Janin-Manificat, H, Malecaze, F, Moali, C, Rovère, MR   +6 more
core   +1 more source