Results 81 to 90 of about 231,791 (288)

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

In vivo Confocal Microscopy for Corneal and Ocular Surface Pathologies: A Comprehensive Review

Clinical Ophthalmology
Arturo Ramirez-Miranda,1 Jesus Guerrero-Becerril,1 Manuel Ramirez,2 Guillermo Raul Vera-Duarte,1 Simran Mangwani-Mordani,1,3,4 Gustavo Ortiz-Morales,1 Alejandro Navas,1 Enrique O Graue-Hernandez,1 Jorge L Alio5 1Departamento de Córnea y Cirugía ...
Ramirez-Miranda A, Guerrero-Becerril J, Ramirez M, Vera-Duarte GR, Mangwani-Mordani S, Ortiz-Morales G, Navas A, Graue-Hernandez EO, Alio JL   +8 more
doaj  

Diagnostic features of Acanthamoeba keratitis via in vivo confocal microscopy

Scientific Reports
In vivo confocal microscopy (IVCM) offers a non-invasive, rapid method for diagnosing Acanthamoeba keratitis (AK) by detecting cysts or trophozoites in the initial clinic visit images.
Joanna Przybek-Skrzypecka, Malcolm Armstrong, Jennifer Kim, Andrew Walkden, Leon Au, Arun Brahma, Fiona Carley, Jaya Devi Chidambaram   +7 more
doaj   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Understanding Keratoconus in Down Syndrome: From Etiology to Management – A Narrative Review

Clinical Ophthalmology
Venugopal Anitha,1 Nambi Nallasamy,2 Josephine S Christy,3 Olav Kristianslund,4 Kirk AJ Stephenson,5 Hassan Hashemi,6 Revathi Rajaraman,7 Soheila Asgari8 1Department of Cornea & Refractive Services, Aravind Eye Hospital and Postgraduate Institute of ...
Anitha V, Nallasamy N, Christy JS, Kristianslund O, Stephenson KAJ, Hashemi H, Rajaraman R, Asgari S   +7 more
doaj  

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Keratorefractive lenticule extraction (KLEx) versus femtosecond laser-assisted in situ keratomileusis (FS-LASIK) for the treatment of myopia and compound myopic astigmatism: study protocol of a randomised clinical trial in Mexico

BMJ Open
Introduction Kerato-lenticule extraction (KLEx) is a refractive surgery technique that, in contrast with femtosecond laser-assisted in situ keratomileusis (FS-LASIK), does not require the creation of a flap to correct refractive defects.
Alejandro Navas, Arturo Ramirez-Miranda, Nicolás Kahuam-López, Mauricio Muleiro-Alvarez, Guillermo Raul Vera-Duarte, Eber A. Medina-Estrada, Gustavo Ortiz-Morales, Enrique L. Graue-Wiechers, Enrique O. Graue-Hernandez   +8 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays

Advanced Science, EarlyView.
ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen, Yuman Li, Chenyu Deng, Leran Li, Zhewen Hu, Boon Chin Heng, Yuting Niu, Shiyu Sun, Min Gao, Xiaopei Chi, Ying He, Mingming Xu, Ying Huang, Xuliang Deng   +13 more
wiley   +1 more source

Clinical and microbiological profile of patients with fungal keratitis demonstrating unusual yeast-like structures in potassium hydroxide with calcofluor white preparation of corneal scraping

Journal of Ophthalmic Inflammation and Infection
Background To report a case series of microbial keratitis showing atypical yeast-like structures in direct microscopy which were culture-negative but subsequently identified as yeast cells by PCR and DNA sequencing. Main text This is a retrospective, non-
Sikha Misra, Savitri Sharma, Manas Ranjan Barik, Nisha Rani, Sujata Das, Srikant Kumar Sahu, Smruti Rekha Priyadarshini, Himansu Sekhar Behera   +7 more
doaj   +1 more source