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Cornea, 2022
Abstract: When treating corneal ectasias, successful corneal cross-linking (CXL) requires three factors: riboflavin saturation of the corneal stroma, ultraviolet (UV) light, and oxygen. Riboflavin is too large to pass through epithelial tight junctions, so traditionally epithelial debridement is performed before riboflavin is applied making ...
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Abstract: When treating corneal ectasias, successful corneal cross-linking (CXL) requires three factors: riboflavin saturation of the corneal stroma, ultraviolet (UV) light, and oxygen. Riboflavin is too large to pass through epithelial tight junctions, so traditionally epithelial debridement is performed before riboflavin is applied making ...
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Corneal Collagen Cross-Linking Complications
Seminars in Ophthalmology, 2017Corneal cross-linking was approved by United States Food and Drug Administration for the treatment of progressive keratoconus in April 2016. As this approach becomes more widely used for the treatment of keratoconus and post-laser in situ keratomileusis (LASIK) ectasia, the medical community is becoming more familiar with potential complications ...
Charisma B, Evangelista +1 more
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Corneal Cross Linking for Keratoconus
Seminars in Ophthalmology, 2010Riboflavin-induced ultraviolet light (UV) cross linking has received a significant amount of attention in recent years. It is currently approved in Europe as a treatment for keratoconus and is also being used for other corneal disorders. The goal of this paper is to review in detail seminal papers and studies that have been done to support cross ...
Anne, Keating +2 more
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Accelerated Corneal Cross-Linking
2018Purpose: Corneal cross-linking (CXL) is a relatively new treatment that offers refractive stability in patients with corneal ectatic disorders. The conventional Dresden protocol has been firstly described, and its effectiveness has been demonstrated by several clinical trials.
Leopoldo Spadea +3 more
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Riboflavin for corneal cross-linking
Drugs of Today, 2016Corneal collagen cross-linking (CXL) with riboflavin and ultraviolet A (UVA) radiation is the first therapeutic modality that appears to arrest the progression of keratoconus and other corneal ectasias. Riboflavin is central to the process, acting as a photosensitizer for the production of oxygen singlets and riboflavin triplets.
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Customized Corneal Cross-Linking
2021Eyes with keratoconus suffer from a focal weakening of the cornea, so why should the entire cornea be treated by cross-linking and not only the pathologic part? This chapter is focusing on the theory, technical requirements, and clinical results of customized CXL showing an improved outcome compared to standard treatment regimes.
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Corneal Collagen Cross-Linking Window Absorption
Cornea, 2013To evaluate the safety and efficacy of treatment of severe infectious corneal ulcers with hypoosmolar riboflavin solution and UV-A collagen cross-linking (CXL) without deepithelizing the cornea.Four eyes of 3 patients with severe keratitis and associated corneal melting, were treated with a new protocol of corneal CXL for infectious keratitis, named ...
Rosetta P +3 more
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Collagen cross-linking and corneal infections
Current Opinion in Ophthalmology, 2013This review presents current data regarding the use of collagen cross-linking in the management of corneal infections. Infectious keratitis can lead to blindness without proper antimicrobial therapy. The disease can still progress and lead to corneal melt despite early detection and management.
Joanne B, Tayapad +2 more
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Pediatric Corneal Cross-Linking
2016Corneal cross-linking (CXL) is a treatment for keratoconus that preserves the corneal tissue in contrast to keratoplasty. CXL has been successfully applied clinically in adult patients for more than a decade. While keratoconus in pediatric patients is often detected at a late stage and progresses fast, clinical management is more difficult.
Sabine Kling, Farhad Hafezi
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Corneal collagen cross-linking for keratoconus
Vestnik oftal'mologii, 2015Over the last decade, corneal collagen cross-linking (CXL) has become a conventional treatment method for progressive keratoconus. Laboratory studies have shown that CXL increases the diameter of collagen fibers and also the number of intra- and interfibrillar cross-links, thus, increasing biomechanical strength of the irradiated cornea.
V V, Zotov, N P, Pashtaev, N A, Pozdeeva
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