Results 51 to 60 of about 9,890 (252)

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Outcomes of accelerated corneal collagen cross-linking in keratoconus

Journal of Ophthalmology, 2018
Keratoconus (KC) is a degenerative noninflammatory disease of the cornea which is characterized be structural changes in the cornea which leads to progressive thinning and bulging in the central and/or peripheral part of the cornea and is accompanied by ...
Drozhzhyna G.I., Troychenko L.F., Naumenko V.A., Ivanova O.N., Sereda E.V.   +4 more
doaj   +1 more source

Complications of Corneal Collagen Cross-Linking [PDF]

Journal of Ophthalmology, 2011
Cross-linking of corneal collagen (CXL) is a promising approach for the treatment of keratoconus and secondary ectasia. Several long-term and short-term complications of CXL have been studied and documented. The possibility of a secondary infection after the procedure exists because the patient is subjected to epithelial debridement and the application
Shikha Dhawan, Kavita Rao, Sundaram Natrajan   +2 more
openaire   +3 more sources

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Accelerated versus conventional corneal collagen cross-linking in the treatment of mild keratoconus: a comparative study

Clinical Ophthalmology, 2014
Ahmed Mohamed SherifFaculty of Medicine, Cairo University, EgyptAim: To evaluate the use of accelerated corneal collagen cross-linking in the management of mild and moderate progressive keratoconus in comparison with conventional cross-linking.Patients ...
Sherif AM
doaj  

Updates on corneal collagen cross-linking: Indications, techniques and clinical outcomes

Journal of Current Ophthalmology, 2017
Purpose: To review the historical background and basic principles of collagen cross-linking, to bring together the data regarding the outcomes and complications of collagen cross-linking and finally to explore the efficacy and safety of new variations of
Mehrdad Mohammadpour, Ahmad Masoumi, Masoud Mirghorbani, Kianoosh Shahraki, Hassan Hashemi   +4 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Clinical Outcomes of Repeated Corneal Crosslinking for Progressive Keratoconus After Failure of Primary Procedure; Safety and Efficacy at 12-Month Follow-Up

Ophthalmology and Therapy
Introduction This study aims to evaluate the efficacy and safety of repeated corneal cross-linking (CXL) in patients with progressive keratoconus who have undergone an unsuccessful primary epithelium-off (epi-off) CXL procedure. Additionally, it compares
Mohamed Elalfy, Eleftherios Chatzimichail, Kareem Mahgoub, Aida Hajjar-Sese, Hasan Naveed, Georgios D. Panos, Khaled Abdelhamid, Frank Blaser, Artemis Matsou, Zisis Gatzioufas   +9 more
doaj   +1 more source

Evaluation of Corneal Aberrometry Parameters Before and After Cross-Linking in Patients with Keratoconus

پزشکی بالینی ابن سینا, 2023
Background and Objective: In the last decade, cross-linking (CXL) has been widely used for treating people with progressive keratoconus. The present study aimed to compare corneal aberrometry parameters before and after CXL in patients with keratoconus ...
Mehdi Alizadeh, Salman Khazaei, Mones Bahramian   +2 more
doaj  

Corneal Collagen Cross-Linking Outcomes: Review [PDF]

The Open Ophthalmology Journal, 2011
Keratoconus is a condition characterized by biomechanical instability of the cornea, presenting in a progressive, asymmetric and bilateral way. Corneal collagen cross-linking with riboflavin and UVA (CXL) is a new technique of corneal tissue strengthening that combines the use of riboflavin as a photo sensitizer and UVA irradiation.
Jankov II, Mirko R, Jovanovic, Vesna, Delevic, Sladjana, Coskunseven, Efekan   +3 more
openaire   +2 more sources