Results 71 to 80 of about 96,845 (174)

Polygonati Rhizoma Attenuates Oxidative Stress‐Induced Senescence in Periodontal Ligament Stem Cells

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Network pharmacology identified the potential targets and pathways of Polygonati Rhizoma (PR) against aging‐related periodontitis through PPI, GO/KEGG enrichment, and molecular docking. Experimental validation in a D‐galactose‐induced senescence model of periodontal ligament stem cells showed that PR‐medicated serum attenuated cellular senescence and ...
Xinran Feng, Ying An, Fanfan Hou, Qian Guo, Shanshan Cai, Hongbin Xu, Youfu He   +6 more
wiley   +1 more source

Retinal Pathology and Synucleinopathy in the Visual Pathway of α‐Synuclein Preformed Fibril Mouse Model of Parkinson's Disease

Brain and Behavior, Volume 16, Issue 5, May 2026.
Schematic summary of visual electrophysiology and retinal and brain pathology. The diagram integrates PVEP abnormalities, retinal pathology, and brain pathology in PFF‐injected mice. Based on behavioral outcomes, the three groups were categorized as control, prodromal PD, and PD, corresponding to the PBS, 3‐month PFF (3 MPI), and 6‐month PFF (6 MPI ...
Qin Zhang, Xin‐Yi Qian, Tao Peng, Xiao‐Ou Hou, Zhen‐Yuan Ma, Jiang Huang, Li‐Fang Hu, Wei‐Feng Luo   +7 more
wiley   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

DUSP1 Attenuates Renal Injury in Diabetic Nephropathy by Modulating Ferroptosis: Evidence From Animal Experiments

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Objective Emerging evidence suggests that ferroptosis contributes significantly to the progression of diabetic nephropathy (DN). This study aimed to explore the potential association between dual specificity phosphatase 1 (DUSP1) and ferroptosis in a streptozotocin‐induced DN rat model.
Jiarong Liu, Junping Zhang, Yun Zou, Wen Chen, Jixiong Xu   +4 more
wiley   +1 more source

A randomised controlled trial on cross‐linking protocols for the treatment of progressive keratoconus using isoosmolar and hypoosmolar riboflavin with the addition of sterile water in thin corneae

Acta Ophthalmologica, Volume 104, Issue 1, Page e63-e74, February 2026.
Abstract Purpose To present the outcomes of a randomised clinical trial for the treatment of progressive keratoconus using different kinds of riboflavin and the addition of sterile water in thin corneae. Methods A randomised study using epithelium‐off corneal cross‐linking (CXL) with continuous UVA irradiance 9 mW/cm2 for 10 min (total fluence 5.4 J ...
Ingemar Gustafsson, Thorbjörg Olafsdottir, Olof Neumann, Dimitrios Bizios, Anders Ivarsen, Jesper Ø. Hjortdal   +5 more
wiley   +1 more source

Phospholipid Interconversion and Transport Are Altered in Glaucoma

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Decreased phosphatidylserine (PS) and increased phosphatidylethanolamine (PE) occur in both trabecular meshwork (TM) cells and aqueous humor due to aberrant phosphatidylserine decarboxylase (PSD) over‐expression, and variation in levels of individual PS or PE species differing by only a few acyl chains occurs due to impaired lipid transport due to ...
Genea Edwards, Ruminder Kaur, Anna Mueller, Noël Ziebarth, Richard K. Lee, Sanjoy K. Bhattacharya   +5 more
wiley   +1 more source

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury

Advanced Science, Volume 13, Issue 3, 14 January 2026.
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
wiley   +1 more source

Topometric Indices And Corneal Densitometry Change After Corneal Refractive Surgery Combined With Simultaneous Collagen Crosslinking

Clinical Ophthalmology, 2019
Yonrawee Piyacomn, Ngamjit Kasetsuwan, Vilavun Puangsricharern, Usanee Reinprayoon, Vannarut Satitpitakul, Patchima Chantaren Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok ...
Piyacomn Y, Kasetsuwan N, Puangsricharern V, Reinprayoon U, Satitpitakul V, Chantaren P   +5 more
doaj  

Selective knockout of murine glutamic acid‐rich protein 2 significantly alters dark continuous noise in rod photoreceptors

The Journal of Physiology, Volume 604, Issue 1, Page 460-478, 1 January 2026.
Abstract figure legend GARP2 has a minor role in maintaining the structural integrity of the rod outer segments as a function of age, but an important role in regulating rod photoreceptor continuous noise, likely through stabilization of PDE6 basal activity.
Delores A. Stacks, Ulisse Bocchero, Marci L. DeRamus, Mai N. Nguyen, Jeffrey Messinger, Timothy W. Kraft, Steven J. Pittler, Johan Pahlberg   +7 more
wiley   +1 more source

Corneal Anterior and Posterior Changes in a Patient With Keratitis Associated With Mycobacterium chelonae: A Case Report

Case Reports in Ophthalmological Medicine, Volume 2026, Issue 1, 2026.
Purpose This report describes a patient with anterior and posterior corneal topographic changes who developed refractory keratitis due to Mycobacterium chelonae, associated with soft contact lens use. Case A 42‐year‐old man presented with blurred vision and pain in his right eye. He used disposable soft contact lenses for 2 weeks with appropriate care.
Ryo Kato, Takashi Ono, Takashi Suzuki, Yukako Taketani, Mikiko Kimakura, Tetsuya Toyono, Makoto Aihara, Takashi Miyai, Cristiano Giusti   +8 more
wiley   +1 more source