Results 71 to 80 of about 5,991 (200)

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Small Incision Lenticule Extraction for Correction of Myopia and Myopic Astigmatism: First 24-Hour Outcomes

Journal of Ophthalmology, 2017
Purpose. To observe the first 24-hour (h) outcomes of the small incision lenticule extraction procedure (SMILE) for myopia and myopic astigmatism. Methods.
Taixiang Liu, Tingting Dan, Yan Luo
doaj   +1 more source

Effect of mydriatic eye drops (combined 0.8% tropicamide and 5% phenylephrine) on the measurements of corneal parameters using Pentacam

Indian Journal of Ophthalmology, 2023
Purpose: The purpose of the study is to investigate the effects of combined 0.8% tropicamide and 5% phenylephrine on the corneal parameters using Pentacam.
Pawan Prasher, Vipan K Vig, Brahmjot Singh, Rajan Sharma, Ashok Sharma   +4 more
doaj   +1 more source

Involvement of bradykinin B2 receptor in pathological vascularization in oxygen-induced retinopathy in mice and rabbit cornea [PDF]

, 2018
The identification of components of the kallikrein-kinin system in the vitreous from patients with microvascular retinal diseases suggests that bradykinin (BK) signaling may contribute to pathogenesis of retinal vascular complications. BK receptor 2 (B2R)
Donnini, Sandra, Giachetti, Antonio, Morbidelli, Lucia, Nannelli, Ginevra, Terzuoli, Erika, Ziche, Marina   +5 more
core   +2 more sources

DUSP1 Attenuates Renal Injury in Diabetic Nephropathy by Modulating Ferroptosis: Evidence From Animal Experiments

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Objective Emerging evidence suggests that ferroptosis contributes significantly to the progression of diabetic nephropathy (DN). This study aimed to explore the potential association between dual specificity phosphatase 1 (DUSP1) and ferroptosis in a streptozotocin‐induced DN rat model.
Jiarong Liu, Junping Zhang, Yun Zou, Wen Chen, Jixiong Xu   +4 more
wiley   +1 more source

Assessment of Early Fuchs Endothelial Corneal Dystrophy and CTG Trinucleotide Expansion Positivity Using Scheimpflug Imaging

Ophthalmology Science
Purpose: To evaluate changes in corneal densitometry and optical aberrations using Scheimpflug imaging in early Fuchs endothelial corneal dystrophy (FECD) and to assess their association with CTG trinucleotide repeat expansion.
Stanley S.J. Poh, MBBS, Kai Yuan Tey, MBBS, Gary S.L. Peh, PhD, Dawn J.H. Neo, MSc, Hla Myint Htoon, PhD, Evan K.L. Lee, Yu Qiang Soh, MBBS, V Vinod Mootha, MD, Jodhbir S. Mehta, PhD   +8 more
doaj   +1 more source

CRISPR-Cas9–based treatment of myocilin-associated glaucoma [PDF]

, 2018
Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss worldwide, with elevated intraocular pressure (IOP) a major risk factor. Myocilin (MYOC) dominant gain-of-function mutations have been reported in ∼4% of POAG cases.
Bugge, Kevin, Clark, Abbot F., Fingert, John H., Jain, Ankur, Kasetti, Ramesh B., Ran, Fei, Searby, Charles C., Sharma, Tasneem P., Sheffield, Val C., Yan, Winston Xia, Zhang, Feng, Zode, Gulab   +11 more
core   +1 more source

A randomised controlled trial on cross‐linking protocols for the treatment of progressive keratoconus using isoosmolar and hypoosmolar riboflavin with the addition of sterile water in thin corneae

Acta Ophthalmologica, Volume 104, Issue 1, Page e63-e74, February 2026.
Abstract Purpose To present the outcomes of a randomised clinical trial for the treatment of progressive keratoconus using different kinds of riboflavin and the addition of sterile water in thin corneae. Methods A randomised study using epithelium‐off corneal cross‐linking (CXL) with continuous UVA irradiance 9 mW/cm2 for 10 min (total fluence 5.4 J ...
Ingemar Gustafsson, Thorbjörg Olafsdottir, Olof Neumann, Dimitrios Bizios, Anders Ivarsen, Jesper Ø. Hjortdal   +5 more
wiley   +1 more source

Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF [PDF]

, 2017
Neovascular retinopathies are leading causes of irreversible blindness. Although vascular endothelial growth factor (VEGF) inhibitors have been established as the mainstay of current treatment, clinical management of these diseases is still limited.
Croci Russo, Diego Omar, Garcia Sanchez, Maria Candela, Gramajo, Ana Laura, Lorenc, Valeria Erika, Luna, José Domingo, Paz, Maria Constanza, Rabinovich, Gabriel Adrián, Ridano, Magali Evelin, Stupirski, Juan Carlos, Subirada Caldarone, Paula Virginia   +9 more
core   +1 more source

Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins [PDF]

, 2020
Background Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...
Aramburu, Ana, Bhatia, Vaibhav, Bhattacharya, Shom S, Calado, Sofia, Chakarova, Christina, de la Cerda, Berta, Diez-Lloret, Andrea, Díaz-Corrales, Francisco J, García-Delgado, Ana B, Massalini, Simone, Montero-Sánchez, Adoración, Rodríguez-Bocanegra, Eduardo, Rodríguez-Martínez, Daniel, Valdés-Sánchez, Lourdes   +13 more
core   +2 more sources